{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:27:37Z","timestamp":1748978857720,"version":"3.38.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JND"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It has not been clear if creatinine is associated with respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression and Cox-regression analyses were performed. We included 233 patients, mean age 62.8, mean disease duration of 18.6 months. At baseline, creatinine was significantly associated with ALSFRS-R, but not with its decline rate. No predictive value was disclosed for FVC, its decline rate, or with survival. We did not confirm that creatinine is a marker of respiratory outcome.<\/jats:p>","DOI":"10.3233\/jnd-200583","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T17:40:15Z","timestamp":1614102015000},"page":"795-799","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Creatinine Level Does Not Predict Respiratory Function in Amyotrophic Lateral Sclerosis"],"prefix":"10.1177","volume":"8","author":[{"given":"Jo\u00e3o","family":"Morgadinho","sequence":"first","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Ana Catarina","family":"Pronto-Laborinho","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Vasco A.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Marta","family":"Gromicho","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Michael","family":"Swash","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Departments of Neurology and Neuroscience, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom"}]},{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Department of Neurology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}]}],"member":"179","reference":[{"key":"10.3233\/JND-200583_ref1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2169\/internalmedicine.51.7465","article-title":"Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: A crosssectional study","volume":"51","author":"Ikeda","year":"2012","journal-title":"Intern Med"},{"key":"10.3233\/JND-200583_ref2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s10072-014-1807-4","article-title":"An exploratory study of serum 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