{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T07:29:49Z","timestamp":1747380589754,"version":"3.38.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JND"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Background: The impact of SARS-CoV-2 infection among neuromuscular diseases with respiratory involvement, including amyotrophic lateral sclerosis (ALS), is still to be elucidated. Objectives: We aim to characterize the clinical outcome of ALS patients non-invasive ventilated (NIV), following SARS-CoV-2 infection. Methods: We analyzed retrospectively our patients followed regularly at our ALS clinic, from the beginning of the COVID-19 pandemic (middle March 2020) to March 2021. We included patients on NIV with a documented SARS-CoV-2 infection. We recorded demographic and clinical data, including from the acute infectious illness. Results: Three men with spinal-onset ALS are described, mean age of onset was 55\u00b19.1 years (45\u201361), and mean disease duration was 17.5\u00b115.9 months (6.1\u201341). All of them were wheelchair-bounded, with a mean ALSFRS-R of 15.3\u00b10.6 (15\u201316). One patient used NIV 15 hours\/day, 2 between 4 to 7 hours\/day, and all used assisted coughing twice daily. None had coexistent comorbidities. They were managed for SARS-CoV-2 infection as outpatients with fluticasone, bronchodilators, azithromycin and increasing frequency of assisted coughing. Supplemental oxygen (mean of 2 liters per minute) was needed in two patients, and one required NIV also during the daytime. Total recovery from SARS-CoV-2 infection was observed in all, despite being in an advanced stage of their disease, with severe respiratory involvement. Conclusions: Prompt medical treatment is recommended for ALS patients with severe disease infected by SARS-CoV-2.<\/jats:p>","DOI":"10.3233\/jnd-210733","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T15:55:55Z","timestamp":1638546955000},"page":"257-259","source":"Crossref","is-referenced-by-count":1,"title":["Impact of SARS-CoV-2 Infection Among Non-Invasive Ventilated ALS Patients"],"prefix":"10.1177","volume":"9","author":[{"given":"Miguel","family":"Oliveira Santos","sequence":"first","affiliation":[{"name":"Institute of Physiology, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"},{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}]},{"given":"Sara","family":"Domingues","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Hospital de Santa Maria\u00e1rio Lisboa Norte, Lisbon, Portugal"}]},{"given":"Marta","family":"Gromicho","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}]},{"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}]},{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"},{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}]}],"member":"179","reference":[{"key":"10.3233\/JND-210733_ref1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijid.2020.01.009","article-title":"The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health \u2013The latest 2019 novel coronavirus outbreak in Wuhan, China","volume":"91","author":"Hui","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.3233\/JND-210733_ref2","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J Autoimmun"},{"key":"10.3233\/JND-210733_ref4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in patients infected with SARS-CoV- a systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.3233\/JND-210733_ref5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/jmv.26427","article-title":"Risk and protective factors of SARS-CoV-2 infection","volume":"93","author":"Takagi","year":"2021","journal-title":"J Med Virol"},{"key":"10.3233\/JND-210733_ref6","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1038\/s41598-021-86694-1","article-title":"A systematic review and meta-analysis of obesity and COVID-19 outcomes","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci Rep"},{"issue":"8","key":"10.3233\/JND-210733_ref7","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.clinph.2020.04.005","article-title":"A proposal for new diagnostic criteria for ALS","volume":"131","author":"Shefner","year":"2020","journal-title":"Clin Neurophysiol"},{"key":"10.3233\/JND-210733_ref8","doi-asserted-by":"crossref","first-page":"117053","DOI":"10.1016\/j.jns.2020.117053","article-title":"Description of 3 patients with myastheniagravis and COVID-19","volume":"417","author":"Rein","year":"2020","journal-title":"J Neurol Sci"},{"key":"10.3233\/JND-210733_ref9","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.2020.0200"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JND-210733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T02:34:42Z","timestamp":1741660482000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JND-210733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":8,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jnd-210733","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"type":"print","value":"2214-3599"},{"type":"electronic","value":"2214-3602"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}