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Thus, understanding the underlying causes of PD is indispensable for the development of novel therapeutics. Glycation, the non-enzymatic reaction between reactive dicarbonyls and amino groups, gives rise to a variety of different reaction products known as advanced glycation end products (AGEs). AGEs accumulate over a proteins life-time, and increased levels of glycation reaction products play a role in diabetic complications. It is now also becoming evident that PD patients also display perturbed sugar metabolism and protein glycation, including that of alpha-synuclein, a key player in PD. Here, we hypothesize that anti-diabetic drugs targeting the levels of glycation precursors, or promoting the clearance of glycated proteins may also prove beneficial for PD patients.<\/jats:p>","DOI":"10.3233\/jpd-171285","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T11:49:34Z","timestamp":1519127374000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Annekatrin","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}]},{"given":"Hugo","family":"Vicente 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