{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:24:21Z","timestamp":1761744261725,"version":"3.44.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Differentiating central from peripheral origins of\nspontaneous nystagmus (SN) is challenging. Looking for a simple sign of\nperipheral disease with the video Head Impulsive Test we noticed\nanti-compensatory eye movements (AQEM) in patients with peripheral\netiologies of spontaneous nystagmus (SN). Here we assess the diagnostic\naccuracy of AQEM in differentiating peripheral from central vestibular\ndisorders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec specific-use=\"heading-level-1\">\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We recorded the eye movements in response to horizontal\n head impulses in a group of 43 consecutive patients with acute\nvestibular syndrome (12 with central, 31 with peripheral disorders), 5\npatients after acute vestibular neurectomy (positive controls) and 39\nhealthy subjects (negative controls). AQEM were defined as quick eye\nmovements (peak velocity above 50\u00b0\/s) in the direction of the head\nmovement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec specific-use=\"heading-level-1\">\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>All patients with peripheral disorders and positive\ncontrols had AQEM (latency 231 \u00b1 53 ms, amplitude 3.4 \u00b1 1.4\u00b0,\nvelocity 166 \u00b1 55\u00b0\/s) when their head was moved to the opposite side\nof the lesion. Central patients did not have AQEM. AQEM occurrence rate was\nhigher in peripheral patients with contralesional (74 \u00b1 4%, mean \u00b1 SD)\n in comparison to ipsilesional (1 \u00b1 4%) impulses (p&lt; 0.001).\nOverall diagnostic accuracy for differentiating central from peripheral\npatients was 96% (95% CI for AUC ROC curve: 0.90 to 1.0) for VOR gain\nand 100% (95% CI: 1.0 to 1.0) for AQEM occurrence rate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec specific-use=\"heading-level-1\">\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>These results suggest that AQEM are a sign of\nvestibular imbalance in a peripheral deficit. In addition to VOR gain they\nshould be added to the evaluation of the head impulse test.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3233\/ves-160566","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T07:30:23Z","timestamp":1454916623000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus"],"prefix":"10.1177","volume":"25","author":[{"given":"L.","family":"Luis","sequence":"first","affiliation":[{"name":"Health Sciences Institute, Portuguese Catholic University,  Lisbon, Portugal"},{"name":"Translational Clinical Physiology Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal"},{"name":"Otolaryngology Unit, Hospital de Cascais, Cascais, Portugal"}]},{"given":"N.","family":"Lehnen","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders, Munich University Hospital, Germany"},{"name":"Department of Neurology, Munich University Hospital, Germany"}]},{"given":"E.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"EMG and Motor Control Unit, Neurology Department, Hospital Cl\u00ednic, Universitat de Barcelona, IDIBAPS, Spain"}]},{"given":"M.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Translational Clinical Physiology Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal"}]},{"given":"E.","family":"Schneider","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders, Munich University Hospital, Germany"},{"name":"Institute for Clinical Neurosciences, Munich University Hospital, Germany"},{"name":"Institute of Medical Technology, Brandenburg University of Technology, Cottbus-Senftenberg, Germany"}]},{"given":"J.","family":"Valls-Sol\u00e9","sequence":"additional","affiliation":[{"name":"EMG and Motor Control Unit, Neurology Department, Hospital Cl\u00ednic, Universitat de Barcelona, IDIBAPS, Spain"}]},{"given":"J.","family":"Costa","sequence":"additional","affiliation":[{"name":"Translational Clinical Physiology Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal"},{"name":"EMG and Motor Control Unit, Neurology Department, Hospital Cl\u00ednic, Universitat de Barcelona, IDIBAPS, Spain"}]}],"member":"179","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_2","DOI":"10.1111\/j.1749-6632.2009.03850.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_2","DOI":"10.1093\/brain\/awh351"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1136\/jnnp.2007.123596"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1212\/01.WNL.0000135022.14937.A9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1161\/STROKEAHA.109.551234"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1212\/WNL.0b013e3181bacf85"},{"key":"e_1_2_1_8_2","first-page":"176","volume-title":"Otolaryng Head Neck","author":"Monsell E.","year":"1995","unstructured":"MonsellE., Editorial: New and revised reporting guidelines from the Committee on Hearing and Equilibrium}, Otolaryng Head Neck 113 (1995), 176-8."},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.1161\/STROKEAHA.111.000033"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_2","DOI":"10.1212\/WNL.0b013e31826e264f"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_2","DOI":"10.1212\/01.WNL.0000141144.02666.8C"}],"container-title":["Journal of Vestibular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/VES-160566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/VES-160566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:20:16Z","timestamp":1757668816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/VES-160566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,2]]},"references-count":10,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.3233\/VES-160566"],"URL":"https:\/\/doi.org\/10.3233\/ves-160566","relation":{},"ISSN":["0957-4271","1878-6464"],"issn-type":[{"type":"print","value":"0957-4271"},{"type":"electronic","value":"1878-6464"}],"subject":[],"published":{"date-parts":[[2015,6,2]]}}}