{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:55:45Z","timestamp":1787064945935,"version":"build-2736575974"},"reference-count":31,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2009.0072","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T05:12:39Z","timestamp":1525237959000},"source":"Crossref","is-referenced-by-count":2,"title":["Lyme Disease"],"prefix":"10.3238","author":[{"given":"Roland","family":"Nau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Christen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Eiffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11437","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"10.3238\/arztebl.2009.0072_ref1","unstructured":"Satz N: Klinik der Lyme-Borreliose. Verlag Hans Huber, Bern, 2. Auflage, 2002."},{"key":"10.3238\/arztebl.2009.0072_ref2","doi-asserted-by":"crossref","unstructured":"L\u00fcnemann JD, Gelderblom H, Sospedra M, Quandt JA, Pinilla C, Marques A, Martin R: Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early Lyme encephalitis. Infect Immun 2007; 75: 243\u201351.","DOI":"10.1128\/IAI.01110-06"},{"key":"10.3238\/arztebl.2009.0072_ref3","doi-asserted-by":"crossref","unstructured":"Ohlenbusch A, Matuschka F-R, Richter D, Christen H-J, Thomssen R, Spielman A, Eiffert H: Etiology of the Acrodermatitis chronica atrophicans lesion in Lyme disease. J Infect Dis 1996; 174: 421\u20133.","DOI":"10.1093\/infdis\/174.2.421"},{"key":"10.3238\/arztebl.2009.0072_ref4","doi-asserted-by":"crossref","unstructured":"Wilske B, Busch U, Eiffert H, Fingerle V, Pfister HW, R\u00f6ssler D, Preac-Mursic V: Diversitiy of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany. Med Microbiol Immunol 1996; 184: 195\u2013201.","DOI":"10.1007\/BF02456135"},{"key":"10.3238\/arztebl.2009.0072_ref5","unstructured":"Robert-Koch-Institut. RKI Ratgeber Infektionskrankheiten \u201eLyme-Borreliose\u201c 2007."},{"key":"10.3238\/arztebl.2009.0072_ref6","unstructured":"Wilske B, Fingerle V: Lyme-Borreliose Diagnostik. Mikrobiologe 2005; 15: 209\u201320."},{"key":"10.3238\/arztebl.2009.0072_ref7","doi-asserted-by":"crossref","unstructured":"Huppertz HI, B\u00f6hme M, Standaert SM, Karch H, Plotkin SA: Incidence of Lyme borreliosis in the W\u00fcrzburg region of Germany. Eur J Clin Microbiol Infect Dis 1999; 18: 697\u2013703.","DOI":"10.1007\/s100960050381"},{"key":"10.3238\/arztebl.2009.0072_ref8","doi-asserted-by":"crossref","unstructured":"Christen H-J, Eiffert H: Lyme-Borreliose: Haut- und Nervensystem. Monatschr Kinderheilk 2003; 151: 1146\u201355.","DOI":"10.1007\/s00112-003-0819-6"},{"key":"10.3238\/arztebl.2009.0072_ref9","doi-asserted-by":"crossref","unstructured":"Christen HJ, Hanefeld F, Eiffert H, Thomssen R: Epidemiology and clinical manifestations of Lyme borreliosis in childhood. A prospective multicentre study with special regard to neuroborreliosis. Acta Paediatr Suppl 1993; 386: 1\u201375.","DOI":"10.1111\/j.1651-2227.1993.tb18082.x"},{"key":"10.3238\/arztebl.2009.0072_ref10","doi-asserted-by":"crossref","unstructured":"Ackermann R, Golmer E, Rehse-K\u00fcpper B: Progressive Borrelien-Enzephalomyelitis. Dtsch Med Wochenschr 1985; 110: 1039\u201342.","DOI":"10.1055\/s-2008-1068956"},{"key":"10.3238\/arztebl.2009.0072_ref11","doi-asserted-by":"crossref","unstructured":"Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC: Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990; 80: 568\u201372.","DOI":"10.1007\/BF00294622"},{"key":"10.3238\/arztebl.2009.0072_ref12","doi-asserted-by":"crossref","unstructured":"Eiffert H, Karsten A, Schlott T, Ohlenbusch A, Laskawi R, Hoppert M, Christen HJ: Acute peripheral facial palsy in Lyme disease \u2013 a distal neuritis at the infection site. Neuropediatrics 2004; 35: 267\u201373.","DOI":"10.1055\/s-2004-821174"},{"key":"10.3238\/arztebl.2009.0072_ref13","unstructured":"Wilske B, Z\u00f6ller L, Brade V, Eiffert H, G\u00f6bel UB, Stanek G, Pfister HW: MiQ12 2000 Lyme-Borreliosis"},{"key":"10.3238\/arztebl.2009.0072_ref14","unstructured":"Kaiser R, K\u00f6lmel HW, Pfister HW, Rauer S, Wilske B: Neuroborreliose (Leitlinie der Deutschen Gesellschaft f\u00fcr Neurologie). In Diener HC et al. (Hrsg.): Leitlinien f\u00fcr Diagnostik und Therapie in der Neurologie, 3. Aufl, Thieme, Stuttgart 2005."},{"key":"10.3238\/arztebl.2009.0072_ref15","doi-asserted-by":"crossref","unstructured":"Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP: Diagnosis of Lyme borreliosis. Clin Microbiol Rev 2005; 18: 484\u2013509.","DOI":"10.1128\/CMR.18.3.484-509.2005"},{"key":"10.3238\/arztebl.2009.0072_ref16","doi-asserted-by":"crossref","unstructured":"Kaiser R: Verlauf der akuten und chronischen Neuroborreliose nach Behandlung mit Ceftriaxon. Nervenarzt 2004; 75: 553\u20137.","DOI":"10.1007\/s00115-003-1560-z"},{"key":"10.3238\/arztebl.2009.0072_ref17","doi-asserted-by":"crossref","unstructured":"Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC et al.: The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis and babesiosis: Clinical practice guidelines by the infectious diseases society of America. IDSA Giudelines 2006; 43: 1089\u2013134.","DOI":"10.1086\/508667"},{"key":"10.3238\/arztebl.2009.0072_ref18","doi-asserted-by":"crossref","unstructured":"Feder HM, Johnson BJB, O\u00b4Connell et al.: A critical appraisal of \u201echronic lyme disease\u201c. N Engl J Med 2007; 357: 1422\u201330.","DOI":"10.1056\/NEJMra072023"},{"key":"10.3238\/arztebl.2009.0072_ref19","doi-asserted-by":"crossref","unstructured":"Nau R, Prange HW, Muth P, Mahr G, Menck S, Kolenda H, S\u00f6rgel F: Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges. Antimicrob Agents Chemother 1993; 37: 1518\u201324.","DOI":"10.1128\/AAC.37.7.1518"},{"key":"10.3238\/arztebl.2009.0072_ref20","doi-asserted-by":"crossref","unstructured":"Krupp LB, Masur D, Schwartz J, Coyle PK, Langenbach LJ, Fernquist SK, Jandorf L, Halperin JJ: Cognitive function in late Lyme borreliosis. Arch Neurol 1991; 48: 1125\u20139.","DOI":"10.1001\/archneur.1991.00530230033017"},{"key":"10.3238\/arztebl.2009.0072_ref21","doi-asserted-by":"crossref","unstructured":"Auwaerter PG: Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to lyme disease. Clin Infect Dis 2007; 45: 143\u20138.","DOI":"10.1086\/518854"},{"key":"10.3238\/arztebl.2009.0072_ref22","doi-asserted-by":"crossref","unstructured":"Krupp LB, Hyman LG, Grimson R et al.: Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology 2003; 60: 1923\u201330.","DOI":"10.1212\/01.WNL.0000071227.23769.9E"},{"key":"10.3238\/arztebl.2009.0072_ref23","doi-asserted-by":"crossref","unstructured":"Seltzer EG, Gerber MA, Cartter ML, Freudigman K, Shapiro ED: Long-term outcomes of persons with Lyme disease. J Am Med Assoc 2000; 283: 609\u201316.","DOI":"10.1001\/jama.283.5.609"},{"key":"10.3238\/arztebl.2009.0072_ref24","doi-asserted-by":"crossref","unstructured":"Stricker RB. Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease. Clin Infect Dis 2007; 45: 149\u201357.","DOI":"10.1086\/518853"},{"key":"10.3238\/arztebl.2009.0072_ref25","doi-asserted-by":"crossref","unstructured":"Eiffert H, Karsten A, Ritter K, Ohlenbusch A, Schlott T, Laskawi R, Christen HJ: Autoantibodies to human manganese superoxide dismutase (MnSOD) in children with facial palsy due to neuroborreliosis. Neuropediatrics 2005; 36: 386\u20138.","DOI":"10.1055\/s-2005-872875"},{"key":"10.3238\/arztebl.2009.0072_ref26","doi-asserted-by":"crossref","unstructured":"Wormser G: Early Lyme disease. New Engl J Med 2006; 354: 2794\u2013801.","DOI":"10.1056\/NEJMcp061181"},{"key":"10.3238\/arztebl.2009.0072_ref27","doi-asserted-by":"crossref","unstructured":"Kohlhepp W, Kuhn W, Kr\u00fcger H: Extrapyramidal features in central Lyme borreliosis. Eur Neurol 1989; 29: 150\u20135.","DOI":"10.1159\/000116399"},{"key":"10.3238\/arztebl.2009.0072_ref28","doi-asserted-by":"crossref","unstructured":"Dinser R, Jendro MC, Schnarr S, Zeidler H: Antibiotic treatment of Lyme borreliosis: what is the evidence? Ann Rheum Dis 2005; 64: 519\u201323.","DOI":"10.1136\/ard.2004.027367"},{"key":"10.3238\/arztebl.2009.0072_ref29","doi-asserted-by":"crossref","unstructured":"Kalish RA, Kaplan RF, Taylor E, Jones-Woodward L, Workman K, Steere AC: Evaluation of study patients with Lyme disease, 10\u201320-year follow-up. J Infect Dis 2001; 183: 453\u201360.","DOI":"10.1086\/318082"},{"key":"10.3238\/arztebl.2009.0072_ref30","doi-asserted-by":"crossref","unstructured":"Steere AC, Malawista SE, Newman JH, Spieler PN, Bartenhagen NH: Antibiotic therapy in Lyme disease. Ann Intern Med 1980; 93: 1\u20138.","DOI":"10.7326\/0003-4819-93-1-8"},{"key":"10.3238\/arztebl.2009.0072_ref31","doi-asserted-by":"crossref","unstructured":"Halperin JJ, Shapiro ED, Logigian E et al.: Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2007; 69: 91\u2013102.","DOI":"10.1212\/01.wnl.0000265517.66976.28"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2009.0072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T04:26:24Z","timestamp":1638851184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2009.0072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,30]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2009.0072","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1155\/2014\/414505","asserted-by":"object"}]},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,30]]}}}