{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:08:00Z","timestamp":1791180480542,"version":"4.1.0"},"reference-count":43,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2010.0684","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T05:19:15Z","timestamp":1525238355000},"source":"Crossref","is-referenced-by-count":11,"title":["Lewy Body and Parkinsonian Dementia"],"prefix":"10.3238","author":[{"given":"Brit","family":"Mollenhauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"F\u00f6rstl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11437","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"10.3238\/arztebl.2010.0684_ref1","doi-asserted-by":"crossref","unstructured":"Bickel H: Dementia in advanced age: estimating incidence and health care costs. Z Gerontol Geriatr 2001; 34(2): 108\u201315.","DOI":"10.1007\/s003910170074"},{"key":"10.3238\/arztebl.2010.0684_ref2","doi-asserted-by":"crossref","unstructured":"Bostrom F, Jonsson L, Minthon L, Londos E: Patients with Lewy body dementia use more resources than those with Alzheimer\u2019s disease. Int J Geriatr Psychiatry 2007; 22(8): 713\u20139.","DOI":"10.1002\/gps.1738"},{"key":"10.3238\/arztebl.2010.0684_ref3","doi-asserted-by":"crossref","unstructured":"Zaccai J, McCracken C, Brayne C: A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing 2005; 34: 561\u20136.","DOI":"10.1093\/ageing\/afi190"},{"key":"10.3238\/arztebl.2010.0684_ref4","doi-asserted-by":"crossref","unstructured":"Aarsland D, Perry R, Larsen JP, et al.: Neuroleptic sensitivity in Parkinson\u2019s disease and parkinsonian dementias. J Clin Psychiatry 2005; 66(5): 633\u20137.","DOI":"10.4088\/JCP.v66n0514"},{"key":"10.3238\/arztebl.2010.0684_ref5","doi-asserted-by":"crossref","unstructured":"Tiraboschi P, Hansen LA, Alford M, et al.: Cholinergic dysfunction in diseases with Lewy bodies. Neurology 2000; 54(2): 407\u201311.","DOI":"10.1212\/WNL.54.2.407"},{"key":"10.3238\/arztebl.2010.0684_ref6","doi-asserted-by":"crossref","unstructured":"Nelson PT, Jicha GA, Kryscio RJ, et al.: Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 2009.","DOI":"10.1007\/s00415-009-5324-y"},{"key":"10.3238\/arztebl.2010.0684_ref7","doi-asserted-by":"crossref","unstructured":"Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE: Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 2001; 16(4): 622\u201330.","DOI":"10.1002\/mds.1120"},{"key":"10.3238\/arztebl.2010.0684_ref8","doi-asserted-by":"crossref","unstructured":"Aarsland D, Ballard C, Larsen JP, McKeith I: A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson\u2019s disease with and without dementia. Int J Geriatr Psychiatry 2001; 16(5): 528\u201336.","DOI":"10.1002\/gps.389"},{"key":"10.3238\/arztebl.2010.0684_ref9","doi-asserted-by":"crossref","unstructured":"McKeith I, O\u2019Brien J, Walker Z, et al.: Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol 2007; 6(4): 305\u201313.","DOI":"10.1016\/S1474-4422(07)70057-1"},{"key":"10.3238\/arztebl.2010.0684_ref10","doi-asserted-by":"crossref","unstructured":"Mollenhauer B, Cepek L, Bibl M, et al.: Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies. Dement Geriatr Cogn Disord 2005; 19(2\u20133): 164\u201370.","DOI":"10.1159\/000083178"},{"key":"10.3238\/arztebl.2010.0684_ref11","unstructured":"Eggert KM, Deuschl G, Gasser T, et al.: Leitlinien in der Neurologie Therapie-Parkinson-Syndrome. In: HC Diener, N Putzki: \u201eLeitlinien f\u00fcr die Diagnostik und Therapie in der Neurologie\u201c 4th edition. Stuttgart: Georg Thieme Verlag 2008."},{"key":"10.3238\/arztebl.2010.0684_ref12","doi-asserted-by":"crossref","unstructured":"Emre M, Aarsland D, Albanese A, et al.: Rivastigmine for Dementia Associated with Parkinson\u2019s Disease. N Engl J Med 2004; 351(24): 2509\u201318.","DOI":"10.1056\/NEJMoa041470"},{"key":"10.3238\/arztebl.2010.0684_ref13","doi-asserted-by":"crossref","unstructured":"McKeith I, Del Ser T, Spano P, et al.: Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 2000; 356(9247): 2031\u20136.","DOI":"10.1016\/S0140-6736(00)03399-7"},{"key":"10.3238\/arztebl.2010.0684_ref14","unstructured":"Deuschl G MW, et al.: ; 2009."},{"key":"10.3238\/arztebl.2010.0684_ref15","doi-asserted-by":"crossref","unstructured":"Minett TS, Thomas A, Wilkinson LM, et al.: What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson\u2019s disease with dementia. Int J Geriatr Psychiatry 2003; 18(11): 988\u201393.","DOI":"10.1002\/gps.995"},{"key":"10.3238\/arztebl.2010.0684_ref16","doi-asserted-by":"crossref","unstructured":"McKeith I, Fairbairn A, Perry R, Thompson P, Perry E: Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ 1992; 305(6855): 673\u20138.","DOI":"10.1136\/bmj.305.6855.673"},{"key":"10.3238\/arztebl.2010.0684_ref17","doi-asserted-by":"crossref","unstructured":"Tulloch JA, Ashwood TJ, Bateman DN, Woodhouse KW: A single-dose study of the pharmacodynamic effects of chlormethiazole, temazepam and placebo in elderly parkinsonian patients. Age Ageing 1991; 20(6): 424\u20139.","DOI":"10.1093\/ageing\/20.6.424"},{"key":"10.3238\/arztebl.2010.0684_ref18","doi-asserted-by":"crossref","unstructured":"Poewe W: When a Parkinson\u2019s disease patient starts to hallucinate. Pract Neurol 2008; 8(4): 238\u201341.","DOI":"10.1136\/jnnp.2008.152579"},{"key":"10.3238\/arztebl.2010.0684_ref19","doi-asserted-by":"crossref","unstructured":"McKeith IG, Dickson DW, Lowe J, et al.: Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology 2005; 65(12): 1863\u201372.","DOI":"10.1212\/WNL.65.12.1992-a"},{"key":"10.3238\/arztebl.2010.0684_ref20","doi-asserted-by":"crossref","unstructured":"McKeith IG, Galasko D, Kosaka K, et al.: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996; 47(5): 1113\u201324.","DOI":"10.1212\/WNL.47.5.1113"},{"key":"10.3238\/arztebl.2010.0684_ref21","doi-asserted-by":"crossref","unstructured":"McKeith IG, Perry EK, Perry RH: Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology 1999; 53(5): 902\u20135.","DOI":"10.1212\/WNL.53.5.902"},{"key":"10.3238\/arztebl.2010.0684_ref22","doi-asserted-by":"crossref","unstructured":"Emre M, Aarsland D, Brown R, et al.: Clinical diagnostic criteria for dementia associated with Parkinson Disease. Mov Disord 2007; 12: 1689\u20131707.","DOI":"10.1002\/mds.21507"},{"key":"10.3238\/arztebl.2010.0684_ref23","unstructured":"Knecht S, Berger K: Vascular factors contributing to the development of dementia. [Einfluss vaskul\u00e4rer Faktoren auf die Entwicklung einer Demenz]. Dtsch Arztebl 2004; 101(31\u201332): A 2185\u20139."},{"key":"10.3238\/arztebl.2010.0684_ref24","doi-asserted-by":"crossref","unstructured":"Mok W, Chow TW, Zheng L, Mack WJ, Miller C: Clinicopathological concordance of dementia diagnoses by community versus tertiary care clinicians. Am J Alzheimers Dis Other Demen 2004; 19(3): 161\u20135.","DOI":"10.1177\/153331750401900309"},{"key":"10.3238\/arztebl.2010.0684_ref25","doi-asserted-by":"crossref","unstructured":"Aarsland D, Larsen JP, Karlsen K, Lim NG, Tandberg E: Mental symptoms in Parkinson\u2019s disease are important contributors to caregiver distress. Int J Geriatr Psychiatry 1999; 14(10): 866\u201374.","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z"},{"key":"10.3238\/arztebl.2010.0684_ref26","doi-asserted-by":"crossref","unstructured":"Emre M: Dementia associated with Parkinson\u2019s disease. Lancet Neurol 2003; 2(4): 229\u201337.","DOI":"10.1016\/S1474-4422(03)00351-X"},{"key":"10.3238\/arztebl.2010.0684_ref27","doi-asserted-by":"crossref","unstructured":"Aarsland D, Zaccai J, Brayne C: A systematic review of prevalence studies of dementia in Parkinson\u2019s disease. Mov Disord 2005; 20(10): 1255\u201363.","DOI":"10.1002\/mds.20527"},{"key":"10.3238\/arztebl.2010.0684_ref28","doi-asserted-by":"crossref","unstructured":"Cummings JL: Intellectual impairment in Parkinson\u2019s disease: clinical, pathologic, and biochemical correlates. J Geriatr Psychiatry Neurol 1988; 1(1): 24\u201336.","DOI":"10.1177\/089198878800100106"},{"key":"10.3238\/arztebl.2010.0684_ref29","doi-asserted-by":"crossref","unstructured":"Dubois B, Pillon B: Cognitive deficits in Parkinson\u2019s disease. J Neurol 1997; 244(1): 2\u20138.","DOI":"10.1007\/PL00007725"},{"key":"10.3238\/arztebl.2010.0684_ref30","doi-asserted-by":"crossref","unstructured":"Stiasny-Kolster K, Doerr Y, Moller JC, et al.: Combination of \u2019idiopathic\u2019 REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain 2005; 128(Pt 1): 126\u201337.","DOI":"10.1093\/brain\/awh322"},{"key":"10.3238\/arztebl.2010.0684_ref31","doi-asserted-by":"crossref","unstructured":"Werhahn KJ: Epilepsy in the elderly [Altersepilepsie]. Dtsch Arztebl Int 2009; 106(9): 135\u201342.","DOI":"10.3238\/arztebl.2009.0135"},{"key":"10.3238\/arztebl.2010.0684_ref32","doi-asserted-by":"crossref","unstructured":"Bonanni L, Thomas A, Tiraboschi P, Perfetti B, Varanese S, Onofrj M: EEG comparisons in early Alzheimer\u2019s disease, dementia with Lewy bodies and Parkinson\u2019s disease with dementia patients with a 2-year follow-up. Brain 2008; 131(Pt 3): 690\u2013705.","DOI":"10.1093\/brain\/awm322"},{"key":"10.3238\/arztebl.2010.0684_ref33","doi-asserted-by":"crossref","unstructured":"Yoshita M, Taki J, Yokoyama K, et al.: Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology 2006; 66(12): 1850\u20134.","DOI":"10.1212\/01.wnl.0000219640.59984.a7"},{"key":"10.3238\/arztebl.2010.0684_ref34","doi-asserted-by":"crossref","unstructured":"Gomez-Tortosa E, Gonzalo I, Fanjul S, et al.: Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease. Arch Neurol 2003; 60(9): 1218\u201322.","DOI":"10.1001\/archneur.60.9.1218"},{"key":"10.3238\/arztebl.2010.0684_ref35","doi-asserted-by":"crossref","unstructured":"Aarsland D, Laake K, Larsen JP, Janvin C: Donepezil for cognitive impairment in Parkinson\u2019s disease: a randomised controlled study. J Neurol Neurosurg Psychiatry 2002; 72(6): 708\u201312.","DOI":"10.1136\/jnnp.72.6.708"},{"key":"10.3238\/arztebl.2010.0684_ref36","doi-asserted-by":"crossref","unstructured":"Putt ME, Ravina B: Randomized, placebo-controlled, parallel group versus crossover study designs for the study of dementia in Parkinson\u2019s disease. Control Clin Trials 2002; 23(2): 111\u201326.","DOI":"10.1016\/S0197-2456(01)00207-0"},{"key":"10.3238\/arztebl.2010.0684_ref37","doi-asserted-by":"crossref","unstructured":"Ravina B, Putt M, Siderowf A, et al.: Donepezil for dementia in Parkinson\u2019s disease: a randomised, double blind, placebo controlled, crossover study. J Neurol Neurosurg Psychiatry 2005; 76(7): 934\u20139.","DOI":"10.1136\/jnnp.2004.050682"},{"key":"10.3238\/arztebl.2010.0684_ref38","doi-asserted-by":"crossref","unstructured":"Beversdorf DQ, Warner JL, Davis RA, Sharma UK, Nagaraja HN, Scharre DW: Donepezil in the treatment of dementia with lewy bodies. Am J Geriatr Psychiatry 2004; 12(5): 542\u20134.","DOI":"10.1097\/00019442-200409000-00016"},{"key":"10.3238\/arztebl.2010.0684_ref39","doi-asserted-by":"crossref","unstructured":"Wild R, Pettit T, Burns A: Cholinesterase inhibitors for dementia with Lewy bodies: Cochrane Database Syst Rev 2003(3): CD003672.","DOI":"10.1002\/14651858.CD003672"},{"key":"10.3238\/arztebl.2010.0684_ref40","doi-asserted-by":"crossref","unstructured":"Bhasin M, Rowan E, Edwards K, McKeith I: Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis. Int J Geriatr Psychiatry 2007; 22(9): 890\u20135.","DOI":"10.1002\/gps.1759"},{"key":"10.3238\/arztebl.2010.0684_ref41","doi-asserted-by":"crossref","unstructured":"Morgante L, Epifanio A, Spina E, et al.: Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis. Clin Neuropharmacol 2004; 27(4): 153\u20136.","DOI":"10.1097\/01.wnf.0000136891.17006.ec"},{"key":"10.3238\/arztebl.2010.0684_ref42","doi-asserted-by":"crossref","unstructured":"Kramer ML, Schulz-Schaeffer WJ: Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007; 27(6): 1405\u201310.","DOI":"10.1523\/JNEUROSCI.4564-06.2007"},{"key":"10.3238\/arztebl.2010.0684_ref43","doi-asserted-by":"crossref","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees A: Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55(3): 181\u20134.","DOI":"10.1136\/jnnp.55.3.181"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2010.0684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T09:53:25Z","timestamp":1638784405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2010.0684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":43,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2010.0684","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s11065-016-9334-0","asserted-by":"object"}]},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,1]]}}}