{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T03:02:06Z","timestamp":1774234926278,"version":"3.50.1"},"reference-count":39,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2013.0227","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:25:18Z","timestamp":1525253118000},"source":"Crossref","is-referenced-by-count":29,"title":["The Prevention, Diagnosis and Treatment of Premature Labor"],"prefix":"10.3238","author":[{"given":"Ekkehard","family":"Schleu\u00dfner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2013,3,29]]},"reference":[{"key":"10.3238\/arztebl.2013.0227_ref1","unstructured":"Deutsche Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe: Leitlinie 015\/025 Medikament\u00f6se Wehenhemmung bei drohender Fr\u00fchgeburt. www.agmfm.de\/_download\/unprotected\/ g_04_03_01_medikamentoese_wehenhemmung.pdf"},{"key":"10.3238\/arztebl.2013.0227_ref2","unstructured":"AQUA \u2013 Institut f\u00fcr angewandte Qualit\u00e4tsf\u00f6rderung und Forschung im Gesundheitswesen GmbH. Bundesauswertung zum Verfahrensjahr 2010 16\/1 \u2013 Geburtshilfe. www.sqg.de\/ergebnisse\/leistungsbereiche\/geburtshilfe.html"},{"key":"10.3238\/arztebl.2013.0227_ref3","unstructured":"EURO-PERISTAT Project: European Perinatal Health Report 2008. www.europeristat.com\/our-publications\/european-perinatal-health-report.html"},{"key":"10.3238\/arztebl.2013.0227_ref4","doi-asserted-by":"crossref","unstructured":"Dudenhausen JW, Friese K, Kirschner W: Pr\u00e4konzeptionelle Gesundheitsberatung und Beratung zur Wahl der Geburtsklinik als weitere Instrumente zur Verringerung von Fr\u00fchgeburten. Z Geburtsh Neonatol 2007; 211: 142\u20136.","DOI":"10.1055\/s-2007-960658"},{"key":"10.3238\/arztebl.2013.0227_ref5","unstructured":"RCOG Green-top Guideline No. 1b, February 2011, Tocolysis for women in preterm labour. www.rcog.org.uk\/files\/rcog-corp\/GTG1b26072011.pdf"},{"key":"10.3238\/arztebl.2013.0227_ref6","doi-asserted-by":"crossref","unstructured":"Di Renzo GC for the European Association of Perinatal Medicine-study group preterm birth: Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth J Mat Fetal Neonat Med 2011; 24: 659\u201367.","DOI":"10.3109\/14767058.2011.553694"},{"key":"10.3238\/arztebl.2013.0227_ref7","doi-asserted-by":"crossref","unstructured":"Management of preterm labour. Practice Bulletin 127. American College of Obstetricians and Gynecologists. Obstet Gynecol 2012; 119: 1308\u201317.","DOI":"10.1097\/AOG.0b013e31825af2f0"},{"key":"10.3238\/arztebl.2013.0227_ref8","doi-asserted-by":"crossref","unstructured":"Flood K, Malone FD: Prevention of preterm birth. Seminars Fetal Neonat Med 2012; 17; 58e63.","DOI":"10.1016\/j.siny.2011.08.001"},{"key":"10.3238\/arztebl.2013.0227_ref9","doi-asserted-by":"crossref","unstructured":"Murphy DJ: Epidemiology and environmental factors in preterm labour. Best Practice & Research Clinical Obstetrics and Gynaecology 2007; 21: 773\u201389.","DOI":"10.1016\/j.bpobgyn.2007.03.001"},{"key":"10.3238\/arztebl.2013.0227_ref10","unstructured":"Cochrane search \u201eprevention and preterm labour\u201c http:\/\/summaries.cochrane.org\/search\/site?f[0] =im_field_terms_cochrane_library%3A51374&f[1]=im_field_stage%3A3&f[2]=im_field_terms_cochrane_library%3A51378. Last accessed on 26 Februrary 2013"},{"key":"10.3238\/arztebl.2013.0227_ref11","doi-asserted-by":"crossref","unstructured":"Bitzer E, Schneider A, Wenzlaff P, Hoyme UB, Siegmund-Schultze E: Self-testing of vaginal pH to prevent preterm delivery: A controlled trial. Dtsch Arztebl Int 2011; 108(6): 81\u20136.","DOI":"10.3238\/arztebl.2011.0081"},{"key":"10.3238\/arztebl.2013.0227_ref12","doi-asserted-by":"crossref","unstructured":"Crane JM, Hutchens D: Transvaginal sonographic measurement of cervical length to predict preterm birth in asymptomatic women at increased risk: a systematic review. Ultrasound Obstet Gynecol 2008; 31: 579\u201387.","DOI":"10.1002\/uog.5323"},{"key":"10.3238\/arztebl.2013.0227_ref13","doi-asserted-by":"crossref","unstructured":"Berghella V, Rafael T, Szychowski JM, Rust OA, Owen J: Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth. Obstet Gynecol 2011; 117: 663\u201371.","DOI":"10.1097\/AOG.0b013e31820ca847"},{"key":"10.3238\/arztebl.2013.0227_ref14","doi-asserted-by":"crossref","unstructured":"Dodd JM, Flenady V, Cincotta R, Crowther CA: Prenatal administration of progesterone for preventing preterm birth. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD004947. DOI: 10.1002\/14651858.CD004947.pub2","DOI":"10.1002\/14651858.CD004947.pub2"},{"key":"10.3238\/arztebl.2013.0227_ref15","doi-asserted-by":"crossref","unstructured":"Romero R, Nicolaides K, Conde-Agudelo A, et al.: Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and meta-analysis of individual patient data. Am J Obstet Gynecol 2012; 206: 124.e1\u201319.","DOI":"10.1016\/j.ajog.2011.12.003"},{"key":"10.3238\/arztebl.2013.0227_ref16","doi-asserted-by":"crossref","unstructured":"Anotayanonth S, Subhedar NV, Garner P, Neilson JP, Harigopal S: Betamimetics for inhibiting preterm labour. The Cochrane Database of Systematic Reviews 2010; 2: CD004352. DOI: 10.1002\/14651858.CD004352.pub2","DOI":"10.1002\/14651858.CD004352.pub2"},{"key":"10.3238\/arztebl.2013.0227_ref17","doi-asserted-by":"crossref","unstructured":"Schleussner E, M\u00f6ller A, Gro\u00df W, et al.: Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate. Eur J Obstet Gynecol Reprod Biol 2003; 106: 14\u20139.","DOI":"10.1016\/S0301-2115(02)00197-5"},{"key":"10.3238\/arztebl.2013.0227_ref18","doi-asserted-by":"crossref","unstructured":"de Heus R, Mol BW, Erwich JJ, et al.: Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study. BMJ 2009; 338: b744.","DOI":"10.1136\/bmj.b744"},{"key":"10.3238\/arztebl.2013.0227_ref19","doi-asserted-by":"crossref","unstructured":"Sp\u00e4tling L, Fallenstein F, Schneider H, Dancis J: Bolus tocolysis: treatment of preterm labor with pulsatile administration of a beta-adrenergic agonist. Am J Obstet Gynecol 1989:160: 713\u20137.","DOI":"10.1016\/S0002-9378(89)80066-3"},{"key":"10.3238\/arztebl.2013.0227_ref20","doi-asserted-by":"crossref","unstructured":"Papatsonis D, Flenady V, Cole S, Liley H: Oxytocin receptor antagonists for inhibiting preterm labour. Cochrane Database of Systematic Reviews 2005; 3: CD004452. DOI: 10.1002\/14651858.CD004452.pub2","DOI":"10.1002\/14651858.CD004452.pub2"},{"key":"10.3238\/arztebl.2013.0227_ref21","doi-asserted-by":"crossref","unstructured":"The Worldwide Atosiban Versus Beta-agonists Study group: Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. Br J Obstet Gynaecol 2001; 108: 133\u201342.","DOI":"10.1111\/j.1471-0528.2001.00043.x"},{"key":"10.3238\/arztebl.2013.0227_ref22","doi-asserted-by":"crossref","unstructured":"King JF, Flenady V, Papatsonis D, Dekker G, Carbonne B: Calcium channel blockers for inhibiting preterm labour. Cochrane Database of Systematic Reviews 2003, Issue 1. Art. No.: CD002255. DOI: 10.1002\/14651858.CD002255.","DOI":"10.1002\/14651858.CD002255"},{"key":"10.3238\/arztebl.2013.0227_ref23","doi-asserted-by":"crossref","unstructured":"Conde-Agudelo A, Romero R, Kusanovic JP: Nifedipine in the management of preterm labor: a systematic review and metaanalysis. Am J Obstet Gynecol 2011; 204: 134.e1\u201320.","DOI":"10.1016\/j.ajog.2010.11.038"},{"key":"10.3238\/arztebl.2013.0227_ref24","unstructured":"Schleu\u00dfner E: Medikament\u00f6se Behandlung bei drohender Fr\u00fchgeburt. Gyn\u00e4kol Prax 2010; 34: 231\u201341."},{"key":"10.3238\/arztebl.2013.0227_ref25","doi-asserted-by":"crossref","unstructured":"Smith GN, Walker MC, Ohlsson A, et al.: Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. Am J Obstet Gynecol 2007; 196: 37.e1\u20138.","DOI":"10.1016\/j.ajog.2006.10.868"},{"key":"10.3238\/arztebl.2013.0227_ref26","doi-asserted-by":"crossref","unstructured":"Gill A, Madsen G, Knox M, et al.: Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches. Am J Obstet Gynecol 2006; 195: 484\u20137.","DOI":"10.1016\/j.ajog.2006.01.103"},{"key":"10.3238\/arztebl.2013.0227_ref27","doi-asserted-by":"crossref","unstructured":"Haas DM, Imperiale TF, Kirkpatrick PR, Klein RW, Zollinger TW, Golichowski AM: Tocolytic therapy: a meta-analysis and decision analysis. Obstet Gynecol 2009; 113: 585\u201394.","DOI":"10.1097\/AOG.0b013e318199924a"},{"key":"10.3238\/arztebl.2013.0227_ref28","doi-asserted-by":"crossref","unstructured":"Norton ME, Merill J, Cooper BA, et al.: Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 1993; 329: 1602\u20137.","DOI":"10.1056\/NEJM199311253292202"},{"key":"10.3238\/arztebl.2013.0227_ref29","doi-asserted-by":"crossref","unstructured":"Amin SB, Sinkin RA, Glantz JC: Meta-analysis of the effect of antenatal indomethacin on neonatal outcomes. Am J Obstet Gynecol 2007; 197: 486.e1\u2013486.10.","DOI":"10.1016\/j.ajog.2007.04.019"},{"key":"10.3238\/arztebl.2013.0227_ref30","doi-asserted-by":"crossref","unstructured":"Crowther CA, Hiller JE, Doyle LW: Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database of Systematic Reviews 2002; 4: CD001060. DOI: 10.1002\/14651858.CD001060.","DOI":"10.1002\/14651858.CD001060"},{"key":"10.3238\/arztebl.2013.0227_ref31","doi-asserted-by":"crossref","unstructured":"Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D: Magnesium suphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database of Systematic Reviews 2009; 1: Art. No.: CD004661. DOI: 10.1002\/14651858.CD004661.pub3.","DOI":"10.1002\/14651858.CD004661.pub3"},{"key":"10.3238\/arztebl.2013.0227_ref32","unstructured":"Schleu\u00dfner E, G\u00f6pel W: Magnesiumsulfat zur Neuroprotektion? Frauenarzt 2011; 52: 570\u201371."},{"key":"10.3238\/arztebl.2013.0227_ref33","doi-asserted-by":"crossref","unstructured":"Roberts D, Dalziel SR: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004454. DOI: 10.1002\/14651858.CD004454.pub2.","DOI":"10.1002\/14651858.CD004454.pub2"},{"key":"10.3238\/arztebl.2013.0227_ref34","doi-asserted-by":"crossref","unstructured":"Been J, Degraeuwe P, Kramer B, Zimmermann L: Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG 2011; 118: 113\u201322.","DOI":"10.1111\/j.1471-0528.2010.02751.x"},{"key":"10.3238\/arztebl.2013.0227_ref35","doi-asserted-by":"crossref","unstructured":"Kenyon S, Boulvain M, Neilson JP: Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2010 Aug 4;(8): CD001058. DOI: 10.1002\/14651858.CD001058.pub2.","DOI":"10.1002\/14651858.CD001058.pub2"},{"key":"10.3238\/arztebl.2013.0227_ref36","doi-asserted-by":"crossref","unstructured":"King JF, Flenady V: Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database of Systematic Reviews, 2002; 4: CD000246.","DOI":"10.1002\/14651858.CD000246"},{"key":"10.3238\/arztebl.2013.0227_ref37","doi-asserted-by":"crossref","unstructured":"Subramaniam A, Abramovici A, Andrews A, Tita AT: Antimicrobials for preterm birth prevention: an overview. Infect Dis Obstet Gynecol 2012; 57159. DOI: 10.1155\/2012\/157159.","DOI":"10.1155\/2012\/157159"},{"key":"10.3238\/arztebl.2013.0227_ref38","doi-asserted-by":"crossref","unstructured":"Maloni JA: Lack of evidence for prescription of antepartum bed rest. Expert Rev Obstet Gynecol. 2011; 6: 385\u201393. DOI: 10.1586\/eog.11.28.","DOI":"10.1586\/eog.11.28"},{"key":"10.3238\/arztebl.2013.0227_ref39","doi-asserted-by":"crossref","unstructured":"Crowther CA, Han S: Hospitalisation and bed rest for multiple pregnancy. Cochrane Database Syst. Rev. 2010; 7: CD000110.","DOI":"10.1002\/14651858.CD000110.pub2"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2013.0227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T13:35:46Z","timestamp":1638797746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2013.0227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,29]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2013.0227","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,29]]}}}