{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:00:47Z","timestamp":1772244047928,"version":"3.50.1"},"reference-count":19,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2014.0481","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T05:19:26Z","timestamp":1525238366000},"source":"Crossref","is-referenced-by-count":6,"title":["Patients With Cancer of Unknown Primary"],"prefix":"10.3238","author":[{"given":"Harald","family":"L\u00f6ffler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Puthenparambil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hielscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Neben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alwin","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2014,7,7]]},"reference":[{"key":"10.3238\/arztebl.2014.0481_ref1","doi-asserted-by":"crossref","unstructured":"L\u00f6ffler H, Neben K, Kr\u00e4mer A: Cancer of unknown primary : Epidemiology and pathogenesis. Radiologe 2014; 54: 107\u201311.","DOI":"10.1007\/s00117-013-2544-z"},{"key":"10.3238\/arztebl.2014.0481_ref2","doi-asserted-by":"crossref","unstructured":"Neben K, H\u00fcbner G, Folprecht G, J\u00e4ger D, Kr\u00e4mer A: Metastases in the absence of a primary tumor: Advances in the diagnosis and treatment of CUP syndrome. Dtsch Arztebl Int 2008; 105: 733\u201340.","DOI":"10.3238\/arztebl.2008.0733"},{"key":"10.3238\/arztebl.2014.0481_ref3","doi-asserted-by":"crossref","unstructured":"Altman E, Cadman E: An analysis of 1539 patients with cancer of unknown primary site. Cancer 1986; 57: 120\u20134.","DOI":"10.1002\/1097-0142(19860101)57:1<120::AID-CNCR2820570124>3.0.CO;2-M"},{"key":"10.3238\/arztebl.2014.0481_ref4","doi-asserted-by":"crossref","unstructured":"Levi F, Te VC, Erler G, Randimbison L, La Vecchia C: Epidemiology of unknown primary tumours. Eur J Cancer 2002; 38: 1810\u20132.","DOI":"10.1016\/S0959-8049(02)00135-1"},{"key":"10.3238\/arztebl.2014.0481_ref5","doi-asserted-by":"crossref","unstructured":"van de Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF: Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984\u20131992. Eur J Cancer 2002; 38: 409\u201313.","DOI":"10.1016\/S0959-8049(01)00378-1"},{"key":"10.3238\/arztebl.2014.0481_ref6","unstructured":"Hess KR, Abbruzzese MC, Lenzi R, Raber MN, Abbruzzese JL: Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma. Clin Cancer Res 1999; 5: 3403\u201310."},{"key":"10.3238\/arztebl.2014.0481_ref7","doi-asserted-by":"crossref","unstructured":"Strojan P, Ferlito A, Langendijk JA, et al.: Contemporary management of lymph node metastases from an unknown primary to the neck: II. a review of therapeutic options. Head Neck 2013; 35: 286\u201393.","DOI":"10.1002\/hed.21899"},{"key":"10.3238\/arztebl.2014.0481_ref8","doi-asserted-by":"crossref","unstructured":"L\u00f6ffler H, Neben K, Kr\u00e4mer A: Structured diagnostics and therapy of the CUP syndrome. Radiologe 2014; 54: 112\u20136.","DOI":"10.1007\/s00117-013-2545-y"},{"key":"10.3238\/arztebl.2014.0481_ref9","doi-asserted-by":"crossref","unstructured":"Fizazi K, Greco FA, Pavlidis N, Pentheroudakis G, Group EGW: Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011; 22: 64\u20138.","DOI":"10.1093\/annonc\/mdr389"},{"key":"10.3238\/arztebl.2014.0481_ref10","doi-asserted-by":"crossref","unstructured":"H\u00fcbner G, Bokemeyer C: CUP-Syndrom \u2013 Tumorerkrankung mit unbekanntem Prim\u00e4rtumor. www.dgho-onkopedia.de\/de\/onkopedia\/archiv\/cup-syndrom\/cup-syndrom-stand-dez.-2005 (last accessed on 14 April 2014)","DOI":"10.1007\/978-3-642-54676-1_494-1"},{"key":"10.3238\/arztebl.2014.0481_ref11","doi-asserted-by":"crossref","unstructured":"Golfinopoulos V, Pentheroudakis G, Salanti G, Nearchou AD, Ioannidis JP, Pavlidis N: Comparative survival with diverse chemotherapy regimens for cancer of unknown primary site: multiple-treatments meta-analysis. Cancer Treat Rev 2009; 35: 570\u20133.","DOI":"10.1016\/j.ctrv.2009.05.005"},{"key":"10.3238\/arztebl.2014.0481_ref12","doi-asserted-by":"crossref","unstructured":"Grambsch P, Therneau T: Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81: 515\u201326.","DOI":"10.1093\/biomet\/81.3.515"},{"key":"10.3238\/arztebl.2014.0481_ref13","doi-asserted-by":"crossref","unstructured":"Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B 1995; 57: 289\u2013300.","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"10.3238\/arztebl.2014.0481_ref14","unstructured":"R Core Team R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria 2013. www.R-project.org\/."},{"key":"10.3238\/arztebl.2014.0481_ref15","doi-asserted-by":"crossref","unstructured":"Oken MM, Creech RH, Tormey DC, et al.: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649\u201355.","DOI":"10.1097\/00000421-198212000-00014"},{"key":"10.3238\/arztebl.2014.0481_ref16","unstructured":"National Comprehensive Cancer Network: Occult Primary (Cancer of Unknown Primary [CUP]). www.nccn.org\/professionals\/physician_gls\/pdf\/occult.pdf (last accessed on 14 April 2014)"},{"key":"10.3238\/arztebl.2014.0481_ref17","doi-asserted-by":"crossref","unstructured":"Petrakis D, Pentheroudakis G, Voulgaris E, Pavlidis N: Prognostication in cancer of unknown primary (CUP): Development of a prognostic algorithm in 311 cases and review of the literature. Cancer Treat Rev 2013; 39: 701\u20138.","DOI":"10.1016\/j.ctrv.2013.03.001"},{"key":"10.3238\/arztebl.2014.0481_ref18","doi-asserted-by":"crossref","unstructured":"Pentheroudakis G, Golfinopoulos V, Pavlidis N: Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer 2007; 43: 2026\u201336.","DOI":"10.1016\/j.ejca.2007.06.023"},{"key":"10.3238\/arztebl.2014.0481_ref19","doi-asserted-by":"crossref","unstructured":"Kaaks R, Sookthai D, Hemminki K, et al.: Risk factors for cancers of unknown primary site: Results from the prospective EPIC cohort. International journal of cancer Journal international du cancer 2014. Int J Cancer 2014 Apr 2. doi: 10.1002\/ijc.28874. [Epub ahead of print].","DOI":"10.1002\/ijc.28874"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2014.0481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T08:40:19Z","timestamp":1638780019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2014.0481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,7]]},"references-count":19,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2014.0481","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/978-3-662-48727-3_48","asserted-by":"object"}]},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,7]]}}}