{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T23:03:17Z","timestamp":1781996597012,"version":"3.54.5"},"reference-count":42,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2017.0824","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:29:13Z","timestamp":1525253353000},"source":"Crossref","is-referenced-by-count":18,"title":["Tranexamic Acid Prophylaxis in Hip and Knee Joint Replacement"],"prefix":"10.3238","author":[{"given":"Matthias","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinnerk","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wiesmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11437","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"10.3238\/arztebl.2017.0824_ref1","unstructured":"Mohib Y, Rashid RH, Ali M, Zubairi AJ, Umer M: Does tranexamic acid reduce blood transfusion following surgery for inter-trochanteric fracture? A randomized control trial. J Pak Med Assoc 2015; 65: 17\u201320."},{"key":"10.3238\/arztebl.2017.0824_ref2","doi-asserted-by":"crossref","unstructured":"Camarasa MA, Oll\u00e9 G, Serra-Prat M, et al.: Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 2006; 96: 576\u201382","DOI":"10.1093\/bja\/ael057"},{"key":"10.3238\/arztebl.2017.0824_ref3","doi-asserted-by":"crossref","unstructured":"Triulzi DJ, Vanek K, Ryan DH, et al.: A clinical and immunologic study of blood transfusion and postoperative bacterial infection in spinal surgery. Transfusion\u00a01992; 32: 517\u201324","DOI":"10.1046\/j.1537-2995.1992.32692367194.x"},{"key":"10.3238\/arztebl.2017.0824_ref4","doi-asserted-by":"crossref","unstructured":"Lannan KL, Sahler J, Spinelli SL, et al.: Transfusion immunomodulation: the case for leukoreduced and (perhaps) washed transfusions. Blood Cells Mol Dis\u00a02013; 50: 61\u20138 MEDLINE","DOI":"10.1016\/j.bcmd.2012.08.009"},{"key":"10.3238\/arztebl.2017.0824_ref5","doi-asserted-by":"crossref","unstructured":"Blumberg N, Heal JM: Immunomodulation by blood transfusion: an evolving scientific and clinical challenge. Am J Med\u00a01996; 101: 299\u2013308.","DOI":"10.1016\/S0002-9343(96)00124-6"},{"key":"10.3238\/arztebl.2017.0824_ref6","doi-asserted-by":"crossref","unstructured":"Elsamadicy AA, Adogwa O, Vuong VD, et al.: Association of intraoperative blood transfusions on postoperative complications, 30-day readmission rates, and 1-year patient-reported outcomes. Spine 2017; 42: 610\u201315","DOI":"10.1097\/BRS.0000000000001803"},{"key":"10.3238\/arztebl.2017.0824_ref7","doi-asserted-by":"crossref","unstructured":"Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J: Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res 2008; 466: 1710\u201315","DOI":"10.1007\/s11999-008-0209-4"},{"key":"10.3238\/arztebl.2017.0824_ref8","doi-asserted-by":"crossref","unstructured":"Innerhofer P, Klingler A, Klimmer C, Fries D, Nussbaumer W: Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty. Transfusion 2005; 45: 103\u201310","DOI":"10.1111\/j.1537-2995.2005.04149.x"},{"key":"10.3238\/arztebl.2017.0824_ref9","doi-asserted-by":"crossref","unstructured":"Meybohm P, Fischer D, Schnitzbauer A, et al.: Patient blood management. Chirurg 2015; 87: 40\u20136","DOI":"10.1007\/s00104-015-3011-3"},{"key":"10.3238\/arztebl.2017.0824_ref10","doi-asserted-by":"crossref","unstructured":"Shander A, van Aken H, Colomina MJ, et al.: Patient blood management in Europe. Br J Anaesth 2012; 109: 55\u201368","DOI":"10.1093\/bja\/aes139"},{"key":"10.3238\/arztebl.2017.0824_ref11","unstructured":"Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte: Trasylol\u00ae (Aprotinin): Umsetzung der Kommissionsentscheidung zum Ruhen der Zulassung. www.bfarm.de\/SharedDocs\/Risikoinformationen\/Pharmakovigilanz\/DE\/RI\/2008\/RI-aprotinin.html (last accessed on 22 June 2017)."},{"key":"10.3238\/arztebl.2017.0824_ref12","doi-asserted-by":"crossref","unstructured":"Draxler DF, Medcalf RL: The fibrinolytic system\u2014more than fibrinolysis? Transfus Med Rev 2015; 29: 102\u20139","DOI":"10.1016\/j.tmrv.2014.09.006"},{"key":"10.3238\/arztebl.2017.0824_ref13","unstructured":"M\u00fcller-Berghaus G, P\u00f6tzsch B: H\u00e4mostaseologie. Berlin, Heidelberg: Springer-Verlag 2013; 1."},{"key":"10.3238\/arztebl.2017.0824_ref14","doi-asserted-by":"crossref","unstructured":"McCormack PL: Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 2012; 72: 585\u2013617","DOI":"10.2165\/11209070-000000000-00000"},{"key":"10.3238\/arztebl.2017.0824_ref15","doi-asserted-by":"crossref","unstructured":"Alshryda S, Sarda P, Sukeik M, Nargol A, Blenkinsopp J, Mason JM: Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br 2011; 93: 1577\u201385","DOI":"10.1302\/0301-620X.93B12.26989"},{"key":"10.3238\/arztebl.2017.0824_ref16","doi-asserted-by":"crossref","unstructured":"Lecker I, Wang DS, Whissell PD, Avramescu S, Mazer CD, Orser BA: Tranexamic acid-associated seizures: causes and treatment. Ann Neurol 2016; 79: 18\u201326","DOI":"10.1002\/ana.24558"},{"key":"10.3238\/arztebl.2017.0824_ref17","unstructured":"Koscielny J, Jambor C: Perioperativer Einsatz von Antifibrinolytika. Vascular Care 2008; 15: 32\u201351."},{"key":"10.3238\/arztebl.2017.0824_ref18","doi-asserted-by":"crossref","unstructured":"Later AFL, Sitniakowsky LS, van Hilten JA, et al.: Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery. J Thorac Cardiovasc Surg 2013; 145: 1611\u20136","DOI":"10.1016\/j.jtcvs.2012.11.042"},{"key":"10.3238\/arztebl.2017.0824_ref19","doi-asserted-by":"crossref","unstructured":"Shen Y, Guo Y, Mikus P, et al.: Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood 2012; 119: 5879\u201387","DOI":"10.1182\/blood-2012-01-407825"},{"key":"10.3238\/arztebl.2017.0824_ref20","unstructured":"PFIZER PHARMA PFE GmbH: Fachinformation \u201eCyclocapron\u00ae\u201c. Fa. Pfizer. www.pfizermed.de\/fileadmin\/produktdatenbank\/pdf\/008797_freigabe.pdf (last accessed on 21 February 2016)."},{"key":"10.3238\/arztebl.2017.0824_ref21","doi-asserted-by":"crossref","unstructured":"Levrat A, Gros A, Rugeri L, et al.: Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth 2008; 100: 792\u20137","DOI":"10.1093\/bja\/aen083"},{"key":"10.3238\/arztebl.2017.0824_ref22","doi-asserted-by":"crossref","unstructured":"Napolitano LM, Cohen MJ, Cotton BA, Schreiber MA, Moore EE: Tranexamic acid in trauma: how should we use it? Trauma Acute Care Surg 2013; 74: 1575\u201387","DOI":"10.1097\/TA.0b013e318292cc54"},{"key":"10.3238\/arztebl.2017.0824_ref23","doi-asserted-by":"crossref","unstructured":"Wengler A, Nimptsch U, Mansky T: Hip and knee replacement in Germany and the USA\u2014analysis of individual inpatient data from German and US hospitals for the years 2005 to 2011. Dtsch Arztebl Int 2014; 111: 407\u201316","DOI":"10.3238\/arztebl.2014.0407"},{"key":"10.3238\/arztebl.2017.0824_ref24","doi-asserted-by":"crossref","unstructured":"Gombotz H, Rehak PH, Shander A, Hofmann A: The second Austrian benchmark study for blood use in elective surgery: results and practice change. Transfusion 2014; 54: 2646\u201357","DOI":"10.1111\/trf.12687"},{"key":"10.3238\/arztebl.2017.0824_ref25","doi-asserted-by":"crossref","unstructured":"Yamasaki S, Masuhara K, Fuji T: Tranexamic acid reduces postoperative blood loss in cementless total hip arthroplasty. J Bone Joint Surg Am 2005; 87: 766\u201370","DOI":"10.2106\/JBJS.D.02046"},{"key":"10.3238\/arztebl.2017.0824_ref26","doi-asserted-by":"crossref","unstructured":"Sukeik M, Alshryda S, Haddad FS, Mason JM: Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br 2011; 93: 39\u201346","DOI":"10.1302\/0301-620X.93B1.24984"},{"key":"10.3238\/arztebl.2017.0824_ref27","doi-asserted-by":"crossref","unstructured":"Farrow LS, Smith TO, Ashcroft GP, Myint PK: A systematic review of tranexamic acid in hip fracture surgery. Br J Clin Pharmacol 2016; 82: 1458\u201370","DOI":"10.1111\/bcp.13079"},{"key":"10.3238\/arztebl.2017.0824_ref28","doi-asserted-by":"crossref","unstructured":"Wei Z, Liu M: The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: a meta-analysis of 2720 cases. Transfus Med 2015; 25: 151\u201362","DOI":"10.1111\/tme.12212"},{"key":"10.3238\/arztebl.2017.0824_ref29","doi-asserted-by":"crossref","unstructured":"CRASH-2 trial collaborators, Shakur H, Roberts I, et al.: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376: 23\u201332","DOI":"10.1016\/S0140-6736(10)60835-5"},{"key":"10.3238\/arztebl.2017.0824_ref30","doi-asserted-by":"crossref","unstructured":"Sabbag OD, Abdel MP, Amundson AW, Larson DR, Pagnano MW: Tranexamic acid was safe in arthroplasty patients with a history of venous thromboembolism: a matched outcome study. J Arthroplasty 2017; 32: 246\u2013250","DOI":"10.1016\/j.arth.2017.02.008"},{"key":"10.3238\/arztebl.2017.0824_ref31","doi-asserted-by":"crossref","unstructured":"Karski J, Djaiani G, Carroll J, et al.: Tranexamic acid and early saphenous vein graft patency in conventional coronary artery bypass graft surgery: a prospective randomized controlled clinical trial. J Thorac Cardiovasc Surg 2005; 130: 309\u201314","DOI":"10.1016\/j.jtcvs.2004.11.015"},{"key":"10.3238\/arztebl.2017.0824_ref32","doi-asserted-by":"crossref","unstructured":"Lin Z, Xiaoyi Z: Tranexamic acid-associated seizures: A meta-analysis. Seizure 2016; 36: 70\u20133","DOI":"10.1016\/j.seizure.2016.02.011"},{"key":"10.3238\/arztebl.2017.0824_ref33","doi-asserted-by":"crossref","unstructured":"Keyl C, Uhl R, Beyersdorf F, et al.: High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg 2011; 39: e114\u201321","DOI":"10.1016\/j.ejcts.2010.12.030"},{"key":"10.3238\/arztebl.2017.0824_ref34","doi-asserted-by":"crossref","unstructured":"Counture P, Lebon JS, Lalibert\u00e9 \u00c9, et al.: Low dose versus high dose tranexamic acid reduces the risk of non-ischemic seizures after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2017; in press.","DOI":"10.1053\/j.jvca.2017.04.026"},{"key":"10.3238\/arztebl.2017.0824_ref35","doi-asserted-by":"crossref","unstructured":"Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM: A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 2014; 96-B: 1005\u201315","DOI":"10.1302\/0301-620X.96B8.33745"},{"key":"10.3238\/arztebl.2017.0824_ref36","doi-asserted-by":"crossref","unstructured":"Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR: Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 2010; 50: 753\u201365","DOI":"10.1111\/j.1537-2995.2009.02518.x"},{"key":"10.3238\/arztebl.2017.0824_ref37","doi-asserted-by":"crossref","unstructured":"Mannucci PM: Hemostatic drugs. N Engl J Med 1998; 339: 245\u201353","DOI":"10.1056\/NEJM199807233390407"},{"key":"10.3238\/arztebl.2017.0824_ref38","doi-asserted-by":"crossref","unstructured":"Tan J, Chen H, Liu Q, Chen C, Huang W: A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 2013; 184: 880\u201387","DOI":"10.1016\/j.jss.2013.03.099"},{"key":"10.3238\/arztebl.2017.0824_ref39","doi-asserted-by":"crossref","unstructured":"Wu Q, Zhang H, Liu S, Meng T, Zhou X, Wang P: Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials. Eur J Orthop Surg Traumatol 2015; 25: 525\u201341","DOI":"10.1007\/s00590-014-1568-z"},{"key":"10.3238\/arztebl.2017.0824_ref40","doi-asserted-by":"crossref","unstructured":"Zhou X, Tao L, Li J, Wu L: Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg 2013; 133: 1017\u201327","DOI":"10.1007\/s00402-013-1761-2"},{"key":"10.3238\/arztebl.2017.0824_ref41","doi-asserted-by":"crossref","unstructured":"Huang F, Wu Y, Yin Z, Ma G, Chang J: A systematic review and meta-analysis of the use of antifibrinolytic agants in total hip arthroplasty. Hip Int 2015; 25: 502\u20139","DOI":"10.5301\/hipint.5000285"},{"key":"10.3238\/arztebl.2017.0824_ref42","doi-asserted-by":"crossref","unstructured":"Moskal JT, Capps SG: Meta-analysis of intravenous tranexamic acid in primary total hip arthroplasty. Orthopedics 2016; 39: 883\u201392","DOI":"10.3928\/01477447-20160526-02"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2017.0824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T10:40:37Z","timestamp":1638873637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2017.0824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":42,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2017.0824","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,1]]}}}