{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T14:40:21Z","timestamp":1705416021002},"reference-count":84,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2017.430","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:29:13Z","timestamp":1525253353000},"source":"Crossref","is-referenced-by-count":5,"title":["Latent Hypothyroidism in Adults"],"prefix":"10.3238","author":[{"given":"Jeannine","family":"Sch\u00fcbel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Feldkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Drossard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"10.3238\/arztebl.2017.430_ref1","doi-asserted-by":"crossref","unstructured":"Ladenson PW, Singer PA, Ain KB, et al.: American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med 2000; 160: 1573\u20135","DOI":"10.1001\/archinte.160.11.1573"},{"key":"10.3238\/arztebl.2017.430_ref2","unstructured":"Muller AF, Berghout A, Wiersinga WM, et al.: Thyroid function disorders\u2014guidelines of the Netherlands Association of Internal Medicine. Neth J Med 2008; 66: 134\u201342"},{"key":"10.3238\/arztebl.2017.430_ref3","doi-asserted-by":"crossref","unstructured":"Hollowell JG, Staehling NW, Flanders WD, et al.: Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489\u201399","DOI":"10.1210\/jcem.87.2.8182"},{"key":"10.3238\/arztebl.2017.430_ref4","doi-asserted-by":"crossref","unstructured":"Canaris GJ, Manowitz NR, Mayor G, Ridgway EC: The Colorado Thyroid Disease Prevalence study. Arch Intern Med 2000; 160: 526\u201334","DOI":"10.1001\/archinte.160.4.526"},{"key":"10.3238\/arztebl.2017.430_ref5","doi-asserted-by":"crossref","unstructured":"Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H: Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status. Eur J Endocrinol 2000; 143: 485\u201391","DOI":"10.1530\/eje.0.1430485"},{"key":"10.3238\/arztebl.2017.430_ref6","doi-asserted-by":"crossref","unstructured":"Vanderpump MPJ, Tunbridge WMG, French JM, et al.: The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin Endocrinol 1995; 43: 55\u201368","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"10.3238\/arztebl.2017.430_ref7","doi-asserted-by":"crossref","unstructured":"Garber JR, Cobin RH, Gharib H, et al.: Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol 2012; 18: 988\u20131028","DOI":"10.4158\/EP12280.GL"},{"key":"10.3238\/arztebl.2017.430_ref8","doi-asserted-by":"crossref","unstructured":"Cooper DS: Clinical practice. Subclinical hypothyroidism. N Engl J Med 2001; 345: 260\u20135","DOI":"10.1056\/NEJM200107263450406"},{"key":"10.3238\/arztebl.2017.430_ref9","doi-asserted-by":"crossref","unstructured":"Biondi B: Mechanisms in endocrinology: heart failure and thyroid dysfunction. Eur J Endocrinol 2012; 167: 609\u201318","DOI":"10.1530\/EJE-12-0627"},{"key":"10.3238\/arztebl.2017.430_ref10","doi-asserted-by":"crossref","unstructured":"Rink T: Das basale TSH \u2013 Grundlagen und aktuelle Interpretation, basierend auf neuen epidemiologischen Daten. Nukl 2009; 32: 199\u2013205","DOI":"10.1055\/s-0029-1234095"},{"key":"10.3238\/arztebl.2017.430_ref11","unstructured":"Brabant G, Kahaly GJ, Schicha H, Teiners C: Milde Formen der Schilddr\u00fcsenfehlfunktion. Dtsch Arztebl 2006; 103: A2110\u20135"},{"key":"10.3238\/arztebl.2017.430_ref12","doi-asserted-by":"crossref","unstructured":"V\u00f6lzke H, Alte D, Kohlmann T, et al.: Reference intervals of serum thyroid function tests in a previously iodine-deficient area. J Am Thyroid Assoc 2005; 15: 279\u201385","DOI":"10.1089\/thy.2005.15.279"},{"key":"10.3238\/arztebl.2017.430_ref13","doi-asserted-by":"crossref","unstructured":"Burkhardt K, Ittermann T, Heier M, et al.: TSH-Referenzbereich bei s\u00fcddeutschen Erwachsenen: Ergebnisse aus der bev\u00f6lkerungsbasierten KORA F4-Studie. Dtsch Med Wochenschr 2014; 139: 317\u201322","DOI":"10.1055\/s-0033-1360046"},{"key":"10.3238\/arztebl.2017.430_ref14","doi-asserted-by":"crossref","unstructured":"Surks MI, Ortiz E, Daniels GH, et al.: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004; 291: 228\u201338","DOI":"10.1001\/jama.291.2.228"},{"key":"10.3238\/arztebl.2017.430_ref15","doi-asserted-by":"crossref","unstructured":"Hamilton TE, Davis S, Onstad L, Kopecky KJ: Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism. J Clin Endocrinol Metab 2008; 93: 1224\u201330","DOI":"10.1210\/jc.2006-2300"},{"key":"10.3238\/arztebl.2017.430_ref16","doi-asserted-by":"crossref","unstructured":"Pearce S, Brabant G, Duntas L, et al.: 2013 ETA-guideline: management of subclinical hypothyroidism. Eur Thyroid J 2013; 2: 215\u201328","DOI":"10.1159\/000356507"},{"key":"10.3238\/arztebl.2017.430_ref17","doi-asserted-by":"crossref","unstructured":"Hennessey JV, Espaillat R: Diagnosis and management of subclinical hypothyroidism in elderly adults: a review of the literature. J Am Geriatr Soc 2015; 63: 1663\u201373","DOI":"10.1111\/jgs.13532"},{"key":"10.3238\/arztebl.2017.430_ref18","doi-asserted-by":"crossref","unstructured":"Karmisholt J, Andersen S, Laurberg P: Variation in thyroid function tests in patients with stable untreated subclinical hypothyroidism. J Am Thyroid Assoc 2008; 18: 303\u20138","DOI":"10.1089\/thy.2007.0241"},{"key":"10.3238\/arztebl.2017.430_ref19","doi-asserted-by":"crossref","unstructured":"Boelaert K, Newby PR, Simmonds MJ, et al.: Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med 2010; 123: 183.e1\u20139","DOI":"10.1016\/j.amjmed.2009.06.030"},{"key":"10.3238\/arztebl.2017.430_ref20","doi-asserted-by":"crossref","unstructured":"Rosenthal MS, Angelos P, Cooper DS, et al.: Clinical and professional ethics guidelines for the practice of thyroidology. J Am Thyroid Assoc 2013; 23: 1203\u201310","DOI":"10.1089\/thy.2013.0124"},{"key":"10.3238\/arztebl.2017.430_ref21","doi-asserted-by":"crossref","unstructured":"Baskin HJ, Cobin RH, Duick DS, et al.: American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol 2002; 8: 457\u201369","DOI":"10.4158\/1934-2403-8.6.457"},{"key":"10.3238\/arztebl.2017.430_ref22","unstructured":"Van Lieshout J, Felix-Schollaart B, Bolsius E, et al.: NHG Standaard Schildklieraandoeningen (tweede herziening). Huisarts & Wetenschap 2013; 56: 2\u201322."},{"key":"10.3238\/arztebl.2017.430_ref23","unstructured":"Sch\u00fcbel J, Voigt K, Gerlach K, Riemenschneider H, Voigt R, Bergmann A: Beratungsanl\u00e4sse bei Neudiagnose \u201eSchilddr\u00fcsenerkrankung\u201c. Z Allg Med 2012; 88: 422."},{"key":"10.3238\/arztebl.2017.430_ref24","doi-asserted-by":"crossref","unstructured":"Vaidya B, Pearce SHS: Management of hypothyroidism in adults. BMJ 2008; 337: a801","DOI":"10.1136\/bmj.a801"},{"key":"10.3238\/arztebl.2017.430_ref25","doi-asserted-by":"crossref","unstructured":"Helfand M, Redfern CC: Clinical guideline, part 1. Screening for thyroid disease: an update. Ann Intern Med 1998; 129: 141\u20133","DOI":"10.7326\/0003-4819-129-2-199807150-00018"},{"key":"10.3238\/arztebl.2017.430_ref26","doi-asserted-by":"crossref","unstructured":"Pham CB, Shaughnessy AF: Should we treat subclinical hypothyroidism? BMJ 2008; 337: a834","DOI":"10.1136\/bmj.a834"},{"key":"10.3238\/arztebl.2017.430_ref27","doi-asserted-by":"crossref","unstructured":"Rugge JB, Bougatsos C, Chou R: Screening and treatment of thyroid dysfunction: an evidence review for the US preventive services task force. Ann Intern Med 2015; 162: 35\u201345","DOI":"10.7326\/M14-1456"},{"key":"10.3238\/arztebl.2017.430_ref28","doi-asserted-by":"crossref","unstructured":"Reuters VS, Almeida CdP, Teixeira PdFdS, et al.: Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life. Arquivos Brasileiros De Endocrinologia E Metabologia 2012; 56: 128\u201336","DOI":"10.1590\/S0004-27302012000200006"},{"key":"10.3238\/arztebl.2017.430_ref29","doi-asserted-by":"crossref","unstructured":"Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI: Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians. Arch Intern Med 2007; 167: 1533\u20138","DOI":"10.1001\/archinte.167.14.1533"},{"key":"10.3238\/arztebl.2017.430_ref30","doi-asserted-by":"crossref","unstructured":"Martins RM, Fonseca RHA, Duarte MMT, et al.: Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function. Arquivos Brasileiros De Endocrinologia E Metabologia 2011; 55: 460\u20137","DOI":"10.1590\/S0004-27302011000700005"},{"key":"10.3238\/arztebl.2017.430_ref31","doi-asserted-by":"crossref","unstructured":"Somwaru LL, Arnold AM, Cappola AR: Predictors of thyroid hormone initiation in older adults: results from the cardiovascular health study. J Gerontol A Biol Sci Med Sci 2011; 66: 809\u201314","DOI":"10.1093\/gerona\/glr063"},{"key":"10.3238\/arztebl.2017.430_ref32","doi-asserted-by":"crossref","unstructured":"Meier C, Staub JJ, Roth CB, et al.: TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab 2001; 86: 4860\u20136","DOI":"10.1210\/jcem.86.10.7973"},{"key":"10.3238\/arztebl.2017.430_ref33","doi-asserted-by":"crossref","unstructured":"Teixeira PFS, Reuters VS, Ferreira MM, et al.: Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial. Horm Metab Res Horm Stoffwechselforschung Horm M\u00e9tabolisme 2008; 40: 50\u20135","DOI":"10.1055\/s-2007-993216"},{"key":"10.3238\/arztebl.2017.430_ref34","doi-asserted-by":"crossref","unstructured":"Villar HCCE, Saconato H, Valente O, Atallah AN: Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev 2007; 3: CD003419","DOI":"10.1002\/14651858.CD003419.pub2"},{"key":"10.3238\/arztebl.2017.430_ref35","unstructured":"Donner-Banzhoff N, Popert U, Altiner A: Haus\u00e4rztliche Beratung zur kardiovaskul\u00e4ren Pr\u00e4vention. 2007. http:\/\/arriba-hausarzt.de\/downloads\/arriba_broschuere.pdf (last accessed on 24 April 2017)."},{"key":"10.3238\/arztebl.2017.430_ref36","doi-asserted-by":"crossref","unstructured":"Parle J, Roberts L, Wilson S, et al.: A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. J Clin Endocrinol Metab 2010; 95: 3623\u201332","DOI":"10.1210\/jc.2009-2571"},{"key":"10.3238\/arztebl.2017.430_ref37","doi-asserted-by":"crossref","unstructured":"Gussekloo J, van Exel E, de Craen AJM, Meinders AE, Fr\u00f6lich M, Westendorp RGJ: Thyroid status, disability and cognitive function, and survival in old age. JAMA 2004; 292: 2591\u20139","DOI":"10.1001\/jama.292.21.2591"},{"key":"10.3238\/arztebl.2017.430_ref38","doi-asserted-by":"crossref","unstructured":"Pecina J, Garrison GM, Bernard ME: Levothyroxine dosage is associated with stability of thyroid-stimulating hormone values. Am J Med 2014; 127: 240\u20135","DOI":"10.1016\/j.amjmed.2013.11.012"},{"key":"10.3238\/arztebl.2017.430_ref39","doi-asserted-by":"crossref","unstructured":"Hannemann A, Friedrich N, Haring R, et al.: Thyroid function tests in patients taking thyroid medication in Germany: results from the population-based Study of Health in Pomerania (SHIP). BMC Res Notes 2010; 3: 227","DOI":"10.1186\/1756-0500-3-227"},{"key":"10.3238\/arztebl.2017.430_ref40","doi-asserted-by":"crossref","unstructured":"Mammen JS, McGready J, Oxman R, Chia CW, Ladenson PW, Simonsick EM: Thyroid hormone therapy and risk of thyrotoxicosis in community-resident older adults: findings from the Baltimore Longitudinal Study of Aging. Thyroid Off J Am Thyroid Assoc 2015; 25: 979\u201386","DOI":"10.1089\/thy.2015.0180"},{"key":"10.3238\/arztebl.2017.430_ref41","doi-asserted-by":"crossref","unstructured":"Rodondi N, den Elzen WPJ, Bauer DC, et al.: Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010; 304: 1365\u201374","DOI":"10.1001\/jama.2010.1361"},{"key":"10.3238\/arztebl.2017.430_ref42","doi-asserted-by":"crossref","unstructured":"Rodondi N, Bauer DC, Cappola AR, et al.: Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure: the cardiovascular health study. J Am Coll Cardiol 2008; 30: 1152\u20139","DOI":"10.1016\/j.jacc.2008.07.009"},{"key":"10.3238\/arztebl.2017.430_ref43","doi-asserted-by":"crossref","unstructured":"Marckmann G, Neitzke G: Ethik, Evidenz und Eigeninteresse: F\u00fcr eine offene Diskurskultur. Ethik Med 2015: 269\u201372.","DOI":"10.1007\/s00481-015-0371-7"},{"key":"10.3238\/arztebl.2017.430_ref44","doi-asserted-by":"crossref","unstructured":"Gogol M, Siebenhofer A: Choosing Wisely \u2013 Gegen \u00dcberversorgung im Gesundheitswesen \u2013 Aktivit\u00e4ten aus Deutschland und \u00d6sterreich am Beispiel der Geriatrie. Wien Med Wochenschr 2016; 166: 155\u201360","DOI":"10.1007\/s10354-015-0424-z"},{"key":"10.3238\/arztebl.2017.430_ref45","unstructured":"AWMF: Gemeinsam klug Entscheiden. www.awmf.org\/medizin-versorgung\/gemeinsam-klug-entscheiden.html (last accessed on 29 April 2016)."},{"key":"10.3238\/arztebl.2017.430_ref46","doi-asserted-by":"crossref","unstructured":"Burns RB, Bates CK, Hartzband P, Smetana GW: Should we treat for subclinical hypothyroidism? Grand rounds discussion from Beth Israel Deaconess Medical Center. Ann Intern Med 2016; 164: 764\u201370","DOI":"10.7326\/M16-0857"},{"key":"10.3238\/arztebl.2017.430_ref47","doi-asserted-by":"crossref","unstructured":"Faust M, Krone W: Zufallsbefund: erh\u00f6hter TSH-Wert. Internist 2014; 55: 1149\u201356","DOI":"10.1007\/s00108-014-3589-4"},{"key":"10.3238\/arztebl.2017.430_ref48","doi-asserted-by":"crossref","unstructured":"K\u00f6hrle PDJ, Brabant G: Synthese, Stoffwechsel und Diagnostik der Schilddr\u00fcsenhormone. Internist 2010; 51: 559\u201367","DOI":"10.1007\/s00108-009-2494-8"},{"key":"10.3238\/arztebl.2017.430_ref49","doi-asserted-by":"crossref","unstructured":"Beckett G, MacKenzie F: Thyroid guidelines\u2014are thyroid-stimulating hormone assays fit for purpose? Ann Clin Biochem 2007; 44: 203\u20138","DOI":"10.1258\/000456307780480945"},{"key":"10.3238\/arztebl.2017.430_ref50","doi-asserted-by":"crossref","unstructured":"Mamtani M, Kulkarni H, Dyer TD, et al.: Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies. BMC Endocr Disord 2014; 14: 46","DOI":"10.1186\/1472-6823-14-46"},{"key":"10.3238\/arztebl.2017.430_ref51","doi-asserted-by":"crossref","unstructured":"Cheserek MJ, Wu G, Shen L, Shi Y, Le G: Evaluation of the relationship between subclinical hypothyroidism and metabolic syndrome components among workers. Int J Occup Med Environ Health 2014; 27: 175\u201387.","DOI":"10.2478\/s13382-014-0240-5"},{"key":"10.3238\/arztebl.2017.430_ref52","doi-asserted-by":"crossref","unstructured":"Rotondi M, Magri F, Chiovato L: Thyroid and obesity: not a one-way interaction. J Clin Endocrinol Metab 2011; 96: 344\u20136","DOI":"10.1210\/jc.2010-2515"},{"key":"10.3238\/arztebl.2017.430_ref53","doi-asserted-by":"crossref","unstructured":"Santini F, Pinchera A, Marsili A, et al.: Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid diseases. J Clin Endocrinol Metab 2005; 90: 124\u20137","DOI":"10.1210\/jc.2004-1306"},{"key":"10.3238\/arztebl.2017.430_ref54","unstructured":"V\u00f6lzke H, Ittermann T, Schmidt CO, et al.: Prevalence trends in lifestyle-related risk factors\u2014two cross-sectional analyses with a total of 8728 participants from the study of health in Pomerania from 1997 to 2001 and 2008 to 2012. Dtsch Arztebl Int 2015; 112: 185\u201392"},{"key":"10.3238\/arztebl.2017.430_ref55","doi-asserted-by":"crossref","unstructured":"Brabant G: Sind die neuen TSH-Normalbereiche klinisch relevant? MMW Fortschr Med 2010; 152: 37\u20139.","DOI":"10.1007\/BF03366322"},{"key":"10.3238\/arztebl.2017.430_ref56","unstructured":"Kahaly GJ, Dietlein M, G\u00e4rtner R, Mann K, Dralle H: Amiodaron und Schilddr\u00fcsendysfunktion. Dtsch Arztebl 2007; 104: A 3550\u20135"},{"key":"10.3238\/arztebl.2017.430_ref57","doi-asserted-by":"crossref","unstructured":"McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR: Lithium toxicity profile: a systematic review and meta-analysis. Lancet 2012; 379: 721\u20138","DOI":"10.1016\/S0140-6736(11)61516-X"},{"key":"10.3238\/arztebl.2017.430_ref58","unstructured":"Wenzel KW: Disturbances of thyroid function tests by drugs. Acta Med Austriaca 1996; 23: 57\u201360."},{"key":"10.3238\/arztebl.2017.430_ref59","doi-asserted-by":"crossref","unstructured":"Woenckhaus U, Vasold A, Bollheimer LC: Akute Nebenniereninsuffizienz (\u201eAddison-Krise\u201c). Intensivmed 2005: 345\u201354.","DOI":"10.1007\/s00390-005-0546-4"},{"key":"10.3238\/arztebl.2017.430_ref60","doi-asserted-by":"crossref","unstructured":"Brabant G: Pulsatile und zirkadiane TSH-Sekretion. Klinische Relevanz? Internist 1998; 39: 619\u201322","DOI":"10.1007\/s001080050223"},{"key":"10.3238\/arztebl.2017.430_ref61","unstructured":"Sch\u00fcbel J, Voigt K, Br\u00fcndel KH, Bergmann A: Erh\u00f6hter TSH-Wert in der Hausarztpraxis. Deutsche Gesellschaft f\u00fcr Allgemeinmedizin und Familienmedizin. Langfassung, Version Juni 2016. www.degam.de\/degam-leitlinien-379.html (last accessed on 16 February 2017)."},{"key":"10.3238\/arztebl.2017.430_ref62","doi-asserted-by":"crossref","unstructured":"Eisenbarth GS, Gottlieb PA: Autoimmune polyendocrine syndromes. N Engl J Med 2004; 350: 2068\u201379","DOI":"10.1056\/NEJMra030158"},{"key":"10.3238\/arztebl.2017.430_ref63","unstructured":"DEGAM Leitlinie: Erh\u00f6hter TSH-Wert in der Hausarztpraxis. S2k-Leitlini (last accessed on 4 May 2017)."},{"key":"10.3238\/arztebl.2017.430_ref64","doi-asserted-by":"crossref","unstructured":"J\u00f8rgensen P, Langhammer A, Krokstad S, Forsmo S: Is there an association between disease ignorance and self-rated health? The HUNT study, a cross-sectional survey. BMJ Open 2014; 4:e004962.","DOI":"10.1136\/bmjopen-2014-004962"},{"key":"10.3238\/arztebl.2017.430_ref65","unstructured":"Nagele W, Nagele J: Aktueller Stand der B-Bild-Schilddr\u00fcsensonographie. J Klin Endokrinol Stoffw 2009; 2: 7\u201314."},{"key":"10.3238\/arztebl.2017.430_ref66","unstructured":"Endocrine Society\u2014thyroid ultrasounds | choosing wisely. www.choosingwisely.org\/clinician-lists\/endocrine-society-thyroid-ultrasounds-in-patients-with-abnormal-thyroid-function-tests\/ (last accessed on 29 April 2016)."},{"key":"10.3238\/arztebl.2017.430_ref67","doi-asserted-by":"crossref","unstructured":"Samuels MH, Schuff KG, Carlson NE, Carello P, Janowsky JS: Health status, mood, and cognition in experimentally induced subclinical hypothyroidism. J Clin Endocrinol Metab 2007; 92: 2545\u201351","DOI":"10.1210\/jc.2007-0011"},{"key":"10.3238\/arztebl.2017.430_ref68","unstructured":"Toward Optimized Practice Clinical Practice Guideline Working Group. Clinical practice guideline: investigation and management of primary thyroid dysfunction 2008."},{"key":"10.3238\/arztebl.2017.430_ref69","doi-asserted-by":"crossref","unstructured":"Helfand M, Redfern CC: Clinical guideline, part 2. Screening for thyroid disease: an update. Ann Intern Med 1998; 129: 144\u201358","DOI":"10.7326\/0003-4819-129-2-199807150-00020"},{"key":"10.3238\/arztebl.2017.430_ref70","unstructured":"TRUST Trial: Thyroid hormone replacement for subclinical hypo-thyroidism trial. www.trustthyroidtrial.com (last accessed on 25 November 2016)."},{"key":"10.3238\/arztebl.2017.430_ref71","doi-asserted-by":"crossref","unstructured":"Sawin CT, Geller A, Wolf PA, et al.: Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 1994; 331: 1249\u201352","DOI":"10.1056\/NEJM199411103311901"},{"key":"10.3238\/arztebl.2017.430_ref72","doi-asserted-by":"crossref","unstructured":"Bauer DC, Ettinger B, Nevitt MC, Stone KL: Study of osteoporotic fractures research group. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med 2001; 134: 561\u20138","DOI":"10.7326\/0003-4819-134-7-200104030-00009"},{"key":"10.3238\/arztebl.2017.430_ref73","doi-asserted-by":"crossref","unstructured":"Abrahamsen B, Eiken P, Prieto-Alhambra D, Eastell R: Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study. BMJ 2016; 353: i3365","DOI":"10.1136\/bmj.i3365"},{"key":"10.3238\/arztebl.2017.430_ref74","doi-asserted-by":"crossref","unstructured":"Hyland KA, Arnold AM, Lee JS, Cappola AR: Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study. J Clin Endocrinol Metab 2013; 98: 533\u201340","DOI":"10.1210\/jc.2012-2180"},{"key":"10.3238\/arztebl.2017.430_ref75","doi-asserted-by":"crossref","unstructured":"Nanchen D, Gussekloo J, Westendorp RGJ, et al.: Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. J Clin Endocrinol Metab 2012; 97: 852\u201361","DOI":"10.1210\/jc.2011-1978"},{"key":"10.3238\/arztebl.2017.430_ref76","doi-asserted-by":"crossref","unstructured":"Razvi S, Weaver JU, Butler TJ, Pearce SHS: Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality. Arch Intern Med 2012; 172: 811\u20137","DOI":"10.1001\/archinternmed.2012.1159"},{"key":"10.3238\/arztebl.2017.430_ref77","doi-asserted-by":"crossref","unstructured":"Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR: High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65\u00a0and over. J Clin Endocrinol Metab 2009; 94: 1342\u20135 MEDLINE","DOI":"10.1210\/jc.2008-1696"},{"key":"10.3238\/arztebl.2017.430_ref78","doi-asserted-by":"crossref","unstructured":"Chu JW, Crapo LM: The treatment of subclinical hypothyroidism is seldom necessary. J Clin Endocrinol Metab 2001; 86: 4591\u20139","DOI":"10.1210\/jcem.86.10.7961"},{"key":"10.3238\/arztebl.2017.430_ref79","unstructured":"Cabral MD, Teixeira P, Soares D, Leite S, Salles E, Waisman M: Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism. Clinics 2011; 66: 1321\u20137"},{"key":"10.3238\/arztebl.2017.430_ref80","doi-asserted-by":"crossref","unstructured":"Mainenti MRM, Vig\u00e1rio PS, Teixeira PFS, Maia MDL, Oliveira FP, Vaisman M: Effect of levothyroxine replacement on exercise performance in subclinical hypothyroidism. J Endocrinol Invest 2009; 32: 470\u20133","DOI":"10.1007\/BF03346488"},{"key":"10.3238\/arztebl.2017.430_ref81","doi-asserted-by":"crossref","unstructured":"Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU: The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 2007; 92: 1715\u201323","DOI":"10.1210\/jc.2006-1869"},{"key":"10.3238\/arztebl.2017.430_ref82","doi-asserted-by":"crossref","unstructured":"Kowalska I, Borawski J, Nikolajuk A, et al.: Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy. Endocrine 2011; 40: 95\u2013101","DOI":"10.1007\/s12020-011-9446-5"},{"key":"10.3238\/arztebl.2017.430_ref83","unstructured":"Beastall, Graham H, Beckett G, et al.: UK guidelines for the use of thyroid function tests. The Association for Clinical Biochemistry; British Thyroid Association; British Thyroid Foundation 2006. www.btf-thyroid.org\/images\/documents\/tft_guideline_final_version_july_2006.pdf (last accessed on 16 Februrary 2017)."},{"key":"10.3238\/arztebl.2017.430_ref84","doi-asserted-by":"crossref","unstructured":"Khandelwal D, Tandon N: Overt and subclinical hypothyroidism: who to treat and how. Drugs 2012; 72: 17\u201333","DOI":"10.2165\/11598070-000000000-00000"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2017.430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T10:27:19Z","timestamp":1638872839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2017.430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":84,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2017.430","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,23]]}}}