{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:10:55Z","timestamp":1789902655858,"version":"4.0.1"},"reference-count":39,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.2020.0137","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T14:02:56Z","timestamp":1582034576000},"source":"Crossref","is-referenced-by-count":16,"title":["Percutaneous Coronary Intervention in Stable Coronary Heart Disease \u2014Is Less More?"],"prefix":"10.3238","author":[{"given":"Hans R.","family":"Figulla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lauten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars S.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Sechtem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmund","family":"Silber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11437","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"10.3238\/arztebl.2020.0137_ref1","doi-asserted-by":"crossref","unstructured":"Mehta SR, Cannon CP, Fox KA, et al.: Routine vs selective invasive strategies in patients with acute coronary syndromes: a collaborative meta-analysis of randomized trials. JAMA 2005; 293: 2908\u201317","DOI":"10.1001\/jama.293.23.2908"},{"key":"10.3238\/arztebl.2020.0137_ref2","doi-asserted-by":"crossref","unstructured":"Knuuti J, Wijns W, Saraste A, et al.: 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 2019; pii: ehz425. doi: 10.1093\/eurheartj\/ehz425. [Epub ahead of print]","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"10.3238\/arztebl.2020.0137_ref3","doi-asserted-by":"crossref","unstructured":"Chang HJ, Lin FY, Gebow D, et al.: Selective referral using CCTA versus direct referral for individuals referred to invasive coronary angiography for suspected CAD: a randomized, controlled, open-label trial. JACC Cardiovasc Imaging 2019; 12 (7 Pt 2): 1303\u201312","DOI":"10.1016\/j.jcmg.2018.09.018"},{"key":"10.3238\/arztebl.2020.0137_ref4","doi-asserted-by":"crossref","unstructured":"Nagel E, Greenwood JP, McCann GP, et al.: Magnetic resonance perfusion or fractional flow reserve in coronary disease. N Engl J Med 2019; 380: 2418\u201328","DOI":"10.1056\/NEJMoa1716734"},{"key":"10.3238\/arztebl.2020.0137_ref5","doi-asserted-by":"crossref","unstructured":"Knuuti J, Ballo H, Juarez-Orozco LE, et al.: The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur Heart J 2018; 39: 3322\u201330","DOI":"10.1093\/eurheartj\/ehy267"},{"key":"10.3238\/arztebl.2020.0137_ref6","doi-asserted-by":"crossref","unstructured":"Hochman JS, Reynolds HR, Bangalore S, et al.: Baseline characteristics and risk profiles of participants in the ISCHEMIA randomized clinical trial. JAMA cardiology 2019; 4: 273\u201386","DOI":"10.1001\/jamacardio.2019.0014"},{"key":"10.3238\/arztebl.2020.0137_ref7","doi-asserted-by":"crossref","unstructured":"Tonino PA, De Bruyne B, Pijls NH, et al.: Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009; 360: 213\u201324","DOI":"10.1056\/NEJMoa0807611"},{"key":"10.3238\/arztebl.2020.0137_ref8","doi-asserted-by":"crossref","unstructured":"Pijls NH, De Bruyne B, Peels K, et al.: Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 1996; 334: 1703\u20138","DOI":"10.1056\/NEJM199606273342604"},{"key":"10.3238\/arztebl.2020.0137_ref9","unstructured":"Ntalianis A, Sels JW, Davidavicius G, et al.: Fractional flow reserve in acute coronary syndromes; factors that might determine the accurate evaluation of the non-culprits. J ACC Cardiovasc Interv 2010;12: 274\u201381."},{"key":"10.3238\/arztebl.2020.0137_ref10","doi-asserted-by":"crossref","unstructured":"Gaede L, M\u00f6llmann H, Rudolph T, Rieber J, Boenner F, Tr\u00f6bs M: Coronary angiography with pressure wire and fractional flow reserve\u2014state of the art in the diagnosis of coronary stenosis. Dtsch Arztebl Int 2019; 116: 205\u201311","DOI":"10.3238\/arztebl.2019.0205"},{"key":"10.3238\/arztebl.2020.0137_ref11","doi-asserted-by":"crossref","unstructured":"Collet C, Onuma Y, Sonck J, et al.: Diagnostic performance of angiography-derived fractional flow reserve: a systematic review and Bayesian meta-analysis. Eur Heart J 2018; 39: 3314\u201321","DOI":"10.1093\/eurheartj\/ehy445"},{"key":"10.3238\/arztebl.2020.0137_ref12","doi-asserted-by":"crossref","unstructured":"Renker M, Schoepf UJ, Becher T, et al.: [Computed tomography in patients with chronic stable angina: fractional flow reserve measurement]. Herz 2017; 42: 51\u20137","DOI":"10.1007\/s00059-016-4433-5"},{"key":"10.3238\/arztebl.2020.0137_ref13","doi-asserted-by":"crossref","unstructured":"Budoff MJ, Mayrhofer T, Ferencik M, et al.: Prognostic value of coronary artery calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). Circulation 2017; 136: 1993\u20132005","DOI":"10.1161\/CIRCULATIONAHA.117.030578"},{"key":"10.3238\/arztebl.2020.0137_ref14","doi-asserted-by":"crossref","unstructured":"Lehmann N, Erbel R, Mahabadi AA, et al.: Value of progression of coronary artery calcification for risk prediction of coronary and cardiovascular events: result of the HNR Study (Heinz Nixdorf Recall). Circulation 2018; 137: 665\u201379","DOI":"10.1161\/CIRCULATIONAHA.116.027034"},{"key":"10.3238\/arztebl.2020.0137_ref15","doi-asserted-by":"crossref","unstructured":"Lin FY, Shaw LJ, Dunning AM, et al.: Mortality risk in symptomatic patients with nonobstructive coronary artery disease: a prospective 2-center study of 2,583 patients undergoing 64-detector row coronary computed tomographic angiography. J Am Coll Cardiol 2011; 58: 510\u20139","DOI":"10.1016\/j.jacc.2010.11.078"},{"key":"10.3238\/arztebl.2020.0137_ref16","doi-asserted-by":"crossref","unstructured":"Tomiyama H, Yamashina A: Non-invasive vascular function tests: their pathophysiological background and clinical application. Circulation 2010; 74: 24\u201333","DOI":"10.1253\/circj.CJ-09-0534"},{"key":"10.3238\/arztebl.2020.0137_ref17","doi-asserted-by":"crossref","unstructured":"Nobuyoshi M, Tanaka M, Nosaka H, et al.: Progression of coronary atherosclerosis: is coronary spasm related to progression? J Am Coll Cardiol 1991; 18: 904\u201310","DOI":"10.1016\/0735-1097(91)90745-U"},{"key":"10.3238\/arztebl.2020.0137_ref18","doi-asserted-by":"crossref","unstructured":"Falk E, Shah PK, Fuster V: Coronary plaque disruption. Circulation 1995; 92: 657\u201371","DOI":"10.1161\/01.CIR.92.3.657"},{"key":"10.3238\/arztebl.2020.0137_ref19","doi-asserted-by":"crossref","unstructured":"Giroud D, Li JM, Urban P, Meier B, Rutishauer W: Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography. Am J Cardiol 1992; 69: 729\u201332","DOI":"10.1016\/0002-9149(92)90495-K"},{"key":"10.3238\/arztebl.2020.0137_ref20","doi-asserted-by":"crossref","unstructured":"Katritsis DG, Ioannidis JP: Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation 2005; 111: 2906\u201312","DOI":"10.1161\/CIRCULATIONAHA.104.521864"},{"key":"10.3238\/arztebl.2020.0137_ref21","doi-asserted-by":"crossref","unstructured":"Windecker S, Stortecky S, Stefanini GG, et al.: Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis. BMJ 2014; 348: g3859","DOI":"10.1136\/bmj.g3859"},{"key":"10.3238\/arztebl.2020.0137_ref22","doi-asserted-by":"crossref","unstructured":"Thomas S, Gokhale R, Boden WE, Devereaux PJ: A meta-analysis of randomized controlled trials comparing percutaneous coronary intervention with medical therapy in stable angina pectoris. Can J Cardiol 2013; 29: 472\u201382","DOI":"10.1016\/j.cjca.2012.07.010"},{"key":"10.3238\/arztebl.2020.0137_ref23","doi-asserted-by":"crossref","unstructured":"Stergiopoulos K, Boden WE, Hartigan P, et al.: Percutaneous coronary intervention outcomes in patients with stable obstructive coronary artery disease and myocardial ischemia: a collaborative meta-analysis of contemporary randomized clinical trials. JAMA Intern Med 2014; 174: 232\u201340","DOI":"10.1001\/jamainternmed.2013.12855"},{"key":"10.3238\/arztebl.2020.0137_ref24","doi-asserted-by":"crossref","unstructured":"Boden WE, O\u2018Rourke RA, Teo KK, et al.: Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007; 356: 1503\u201316","DOI":"10.1056\/NEJMoa070829"},{"key":"10.3238\/arztebl.2020.0137_ref25","doi-asserted-by":"crossref","unstructured":"Sedlis SP, Hartigan PM, Teo KK, et al.: Effect of PCI on long-term survival in patients with stable ischemic heart disease. N Engl J Med 2015; 373: 1937\u201346","DOI":"10.1056\/NEJMoa1505532"},{"key":"10.3238\/arztebl.2020.0137_ref26","doi-asserted-by":"crossref","unstructured":"Group ITR, Maron DJ, Hochman JS, et al.: International study of comparative health effectiveness with medical and invasive approaches (ISCHEMIA) trial: rationale and design. Am Heart J 2018; 201: 124\u201335","DOI":"10.1016\/j.ahj.2018.04.011"},{"key":"10.3238\/arztebl.2020.0137_ref27","unstructured":"International study of comparative health effectiveness with medical and invasive approaches (ISCHEMIA). www.clinicaltrials.gov NCT.01471522. 2002 (last accessed on 11 February 2020)."},{"key":"10.3238\/arztebl.2020.0137_ref28","unstructured":"Hochman J: ISCHEMIA trial: primary report of clinical outcomes. Presentation at the American Heart Association Meeting, Philadelphia, November 2019. 2019."},{"key":"10.3238\/arztebl.2020.0137_ref29","doi-asserted-by":"crossref","unstructured":"De Bruyne B, Fearon WF, Pijls NH, et al.: Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 2014; 371: 1208\u201317","DOI":"10.1056\/NEJMoa1408758"},{"key":"10.3238\/arztebl.2020.0137_ref30","doi-asserted-by":"crossref","unstructured":"Xaplanteris P, Fournier S, Pijls NHJ, et al.: Five-year outcomes with PCI guided by fractional flow reserve. N Engl J Med 2018; 379: 250\u20139","DOI":"10.1056\/NEJMoa1803538"},{"key":"10.3238\/arztebl.2020.0137_ref31","doi-asserted-by":"crossref","unstructured":"Group BDS, Frye RL, August P, et al.: A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009; 360: 2503\u201315","DOI":"10.1056\/NEJMoa0805796"},{"key":"10.3238\/arztebl.2020.0137_ref32","doi-asserted-by":"crossref","unstructured":"Doenst T, Haverich A, Serruys P, et al.: PCI and CABG for treating stable coronary artery disease: JACC review topic of the week. J Am Coll Cardiol 2019; 73: 964\u201376","DOI":"10.1016\/j.jacc.2018.11.053"},{"key":"10.3238\/arztebl.2020.0137_ref33","doi-asserted-by":"crossref","unstructured":"Spertus J: ISCHEMIA trial: primary report of quality of life outcomes. Presentation at the American Heart Association Meeting, Philadelphia, November 2019. 2019","DOI":"10.1016\/j.ahj.2019.09.001"},{"key":"10.3238\/arztebl.2020.0137_ref34","doi-asserted-by":"crossref","unstructured":"Al-Lamee R, Thompson D, Dehbi HM, et al.: Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. Lancet 2018; 391: 31\u201340","DOI":"10.1016\/j.jvs.2017.11.046"},{"key":"10.3238\/arztebl.2020.0137_ref35","unstructured":"Deutsche Herzstiftung: Deutscher Herzbericht 2015. www.herzstiftung.de\/herzbericht (last accessed on 31 January 2020)."},{"key":"10.3238\/arztebl.2020.0137_ref36","unstructured":"Deutsche Herzstiftung: Deutscher Herzbericht 2018. www.herzstiftung.de (last accessed on 31 January 2020)."},{"key":"10.3238\/arztebl.2020.0137_ref37","unstructured":"Institut f\u00fcr Qualit\u00e4tssicherung und Transparenz im Gesundheitswesen: QS-Berichte: Daten 2017. https:\/\/iqtig.org\/qs-berichte\/bundesauswertung\/ (last accessed on 5 January 2020)."},{"key":"10.3238\/arztebl.2020.0137_ref38","doi-asserted-by":"crossref","unstructured":"Harle T, Zeymer U, Hochadel M, et al.: Real-world use of fractional flow reserve in Germany: results of the prospective ALKK coronary angiography and PCI registry. Clin Res Cardiol 2017; 106: 140\u201350","DOI":"10.1007\/s00392-016-1034-5"},{"key":"10.3238\/arztebl.2020.0137_ref39","unstructured":"Deutsches \u00c4rzteblatt: Klinik Codex \u201eMedizin vor \u00d6konomie\u201c. Dtsch Arztebl 2017; 114: 4"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2020.0137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T09:52:09Z","timestamp":1638784329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.2020.0137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3238\/arztebl.2020.0137","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]}}}