{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:26:15Z","timestamp":1786739175935,"version":"build-2736575974"},"reference-count":50,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.m2023.0243","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:41:51Z","timestamp":1705412511000},"source":"Crossref","is-referenced-by-count":7,"title":["Blood product transfusions for children in the perioperative period and for critically ill children"],"prefix":"10.3238","author":[{"given":"Eva","family":"Wittenmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Piekarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea U.","family":"Steinbicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11437","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"10.3238\/arztebl.m2023.0243_ref1","doi-asserted-by":"crossref","unstructured":"Anthes E: Evidence-based medicine: save blood, save lives. Nature 2015; 520: 24–6.","DOI":"10.1038\/520024a"},{"key":"10.3238\/arztebl.m2023.0243_ref2","unstructured":"WHO: Sixty-Third World Health Assembly WHA 63.12 Ai, 21 May 2010 – Availability, safety and quality of blood products. 2010. https:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA63\/A63_R12-en.pdf (last accessed on 4 December 2023)."},{"key":"10.3238\/arztebl.m2023.0243_ref3","doi-asserted-by":"crossref","unstructured":"Goobie SM, DiNardo JA, Faraoni D: Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery. Transfusion 2016; 56: 2487–94.","DOI":"10.1111\/trf.13732"},{"key":"10.3238\/arztebl.m2023.0243_ref4","doi-asserted-by":"crossref","unstructured":"Salvin JW, Scheurer MA, Laussen PC, et al.: Blood transfusion after pediatric cardiac surgery is associated with prolonged hospital stay. Ann Thorac Surg 2011; 91: 204–10.","DOI":"10.1016\/j.athoracsur.2010.07.037"},{"key":"10.3238\/arztebl.m2023.0243_ref5","doi-asserted-by":"crossref","unstructured":"Piekarski F, Steinbicker A, Zacharowski K, Meybohm P: Changes in transfusion practice in children and adolescents over time. Transfus Med Hemother 2020; 47: 379–84.","DOI":"10.1159\/000511231"},{"key":"10.3238\/arztebl.m2023.0243_ref6","doi-asserted-by":"crossref","unstructured":"Goel R, Josephson CD, Patel EU, et al.: Individual- and hospital-level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion 2020; 60: 1700–12.","DOI":"10.1111\/trf.15855"},{"key":"10.3238\/arztebl.m2023.0243_ref7","doi-asserted-by":"crossref","unstructured":"Nellis ME, Goel R, Hendrickson JE, et al.: Transfusion practices in a large cohort of hospitalized children. Transfusion 2021; 61: 2042–53.","DOI":"10.1111\/trf.16443"},{"key":"10.3238\/arztebl.m2023.0243_ref8","doi-asserted-by":"crossref","unstructured":"Fuchs A, Disma N, Virag K, et al.: Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: a prospective European multicentre observational study. Eur J Anaesthesiol 2022; 39: 252–60.","DOI":"10.1097\/EJA.0000000000001646"},{"key":"10.3238\/arztebl.m2023.0243_ref9","doi-asserted-by":"crossref","unstructured":"McGovern PE, Wu L, Rao S, et al.: Audit of blood product utilization in the care of injured children. Paediatr Anaesth 2021; 31: 186–96.","DOI":"10.1111\/pan.14077"},{"key":"10.3238\/arztebl.m2023.0243_ref10","unstructured":"Querschnitts-Leitlinien (B\u00c4K) zur Therapie mit Blukomponenten und Plasmaderivaten – (Gesamtnovelle 2020) www.bundesaerztekammer.de\/fileadmin\/user_upload\/_old-files\/downloads\/pdf-Ordner\/MuE\/Querschnitts-Leitlinien_BAEK_zur_Therapie_mit_Blutkomponenten_und_Plasmaderivaten-Gesamtnovelle_2020.pdf (last accessed on 4 December 2023)"},{"key":"10.3238\/arztebl.m2023.0243_ref11","doi-asserted-by":"crossref","unstructured":"Lacroix J, Hebert PC, Hutchison JS, et al.: Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356: 1609–19.","DOI":"10.1056\/NEJMoa066240"},{"key":"10.3238\/arztebl.m2023.0243_ref12","doi-asserted-by":"crossref","unstructured":"Whyte R, Kirpalani H: Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev 2011; 11: CD000512.","DOI":"10.1002\/14651858.CD000512.pub2"},{"key":"10.3238\/arztebl.m2023.0243_ref13","doi-asserted-by":"crossref","unstructured":"McCoy TE, Conrad AL, Richman LC, Lindgren SD, Nopoulos PC, Bell EF: Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol 2011; 17: 347–67.","DOI":"10.1080\/09297049.2010.544647"},{"key":"10.3238\/arztebl.m2023.0243_ref14","doi-asserted-by":"crossref","unstructured":"Whyte RK, Kirpalani H, Asztalos EV, et al.: Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009; 123: 207–13.","DOI":"10.1542\/peds.2008-0338"},{"key":"10.3238\/arztebl.m2023.0243_ref15","doi-asserted-by":"crossref","unstructured":"Kirpalani H, Whyte RK, Andersen C, et al.: The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149: 301–7.","DOI":"10.1016\/j.jpeds.2006.05.011"},{"key":"10.3238\/arztebl.m2023.0243_ref16","doi-asserted-by":"crossref","unstructured":"Bell EF, Strauss RG, Widness JA, et al.: Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005; 115: 1685–91.","DOI":"10.1542\/peds.2004-1884"},{"key":"10.3238\/arztebl.m2023.0243_ref17","unstructured":"Franz AR, Engel C, Bassler D, et al.: Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. Jama 2020; 324: 560–70."},{"key":"10.3238\/arztebl.m2023.0243_ref18","unstructured":"Kirpalani H, Bell EF, Hintz SR, et al.: Higher or lower hemoglobin transfusion thresholds for preterm infants. N Engl J Med 2020; 383: 2639–51."},{"key":"10.3238\/arztebl.m2023.0243_ref19","doi-asserted-by":"crossref","unstructured":"New HV, Berryman J, Bolton-Maggs PH, et al.: Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol 2016; 175: 784–828.","DOI":"10.1111\/bjh.14233"},{"key":"10.3238\/arztebl.m2023.0243_ref20","doi-asserted-by":"crossref","unstructured":"Kietaibl S, Ahmed A, Afshari A, et al.: Management of severe peri-operative bleeding: guidelines from the European Society of Anaesthesiology and Intensive Care: second update 2022. Eur J Anaesthesiol 2023; 40: 226–304.","DOI":"10.1097\/EJA.0000000000001803"},{"key":"10.3238\/arztebl.m2023.0243_ref21","doi-asserted-by":"crossref","unstructured":"Valentine SL, Bembea MM, Muszynski JA, et al.: Consensus recommendations for RBC transfusion practice in critically Ill children from the pediatric critical care transfusion and anemia expertise initiative. Pediatr Crit Care Med 2018; 19: 884–98.","DOI":"10.1097\/PCC.0000000000001590"},{"key":"10.3238\/arztebl.m2023.0243_ref22","unstructured":"Australian National Health Authority: Patient blood management Guidelines; Module 6 Neonatal and pediatric www.blood.gov.au\/pbm-module-6 (last accessed on 4 December 2023)."},{"key":"10.3238\/arztebl.m2023.0243_ref23","unstructured":"Canadian Blood Service: Clinical guide to transfusion 2017; www.professionaleducationbloodca\/en\/neonatal-and-pediatric-transfusion (last accessed on 4 December 2023)."},{"key":"10.3238\/arztebl.m2023.0243_ref24","doi-asserted-by":"crossref","unstructured":"Faraoni D, Meier J, New HV, Van der Linden PJ, Hunt BJ: Patient blood management for neonates and children undergoing cardiac surgery: 2019 NATA Guidelines. J Cardiothorac Vasc Anesth 2019; 33: 3249–63.","DOI":"10.1053\/j.jvca.2019.03.036"},{"key":"10.3238\/arztebl.m2023.0243_ref25","doi-asserted-by":"crossref","unstructured":"Carson JL, Stanworth SJ, Guyatt G, et al.: Red blood cell transfusion: 2023 AABB international guidelines. JAMA 2023; doi: 10.1001\/jama.2023.12914. Online ahead of print.","DOI":"10.1001\/jama.2023.12914"},{"key":"10.3238\/arztebl.m2023.0243_ref26","doi-asserted-by":"crossref","unstructured":"de Gast-Bakker DH, de Wilde RB, Hazekamp MG, et al.: Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial. Intensive Care Med 2013; 39: 2011–9.","DOI":"10.1007\/s00134-013-3085-7"},{"key":"10.3238\/arztebl.m2023.0243_ref27","doi-asserted-by":"crossref","unstructured":"Cholette JM, Rubenstein JS, Alfieris GM, Powers KS, Eaton M, Lerner NB: Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy. Pediatr Crit Care Med 2011; 12: 39–45.","DOI":"10.1097\/PCC.0b013e3181e329db"},{"key":"10.3238\/arztebl.m2023.0243_ref28","doi-asserted-by":"crossref","unstructured":"Willems A, Harrington K, Lacroix J, et al.: Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis. Crit Care Med 2010; 38: 649–56.","DOI":"10.1097\/CCM.0b013e3181bc816c"},{"key":"10.3238\/arztebl.m2023.0243_ref29","doi-asserted-by":"crossref","unstructured":"Cholette JM, Swartz MF, Rubenstein J, et al.: Outcomes using a conservative versus liberal red blood cell transfusion strategy in infants requiring cardiac operation. Ann Thorac Surg 2017; 103: 206–14.","DOI":"10.1016\/j.athoracsur.2016.05.049"},{"key":"10.3238\/arztebl.m2023.0243_ref30","doi-asserted-by":"crossref","unstructured":"Duan ZX, Chen DX, Yang BZ, Zhang XQ: Transfusion strategies for pediatric cardiac surgery: a meta-analysis and trial sequential analysis. Pediatr Cardiol 2021; 42: 1241–1251. doi: 10.1007\/s00246–021–02644–8. Epub 2021 May 28. PMID: 34050374; PMCID: PMC8162158.","DOI":"10.1007\/s00246-021-02644-8"},{"key":"10.3238\/arztebl.m2023.0243_ref31","doi-asserted-by":"crossref","unstructured":"Wittenmeier E, Komorek Y, Engelhard K: Current hemoglobin thresholds in pediatric anesthesia—guidelines and studies. Curr Opin Anaesthesiol 2023; 36: 301–10.","DOI":"10.1097\/ACO.0000000000001253"},{"key":"10.3238\/arztebl.m2023.0243_ref32","doi-asserted-by":"crossref","unstructured":"Downey LA, Goobie SM: Perioperative pediatric erythrocyte transfusions: incorporating hemoglobin thresholds and physiologic parameters in decision-making. Anesthesiology 2022; 137: 604–19.","DOI":"10.1097\/ALN.0000000000004357"},{"key":"10.3238\/arztebl.m2023.0243_ref33","doi-asserted-by":"crossref","unstructured":"Steinbicker AU, Wittenmeier E, Goobie SM: Pediatric non-red cell blood product transfusion practices: what‘s the evidence to guide transfusion of the ‚yellow‘ blood products? Curr Opin Anaesthesiol 2020; 33: 259–67.","DOI":"10.1097\/ACO.0000000000000838"},{"key":"10.3238\/arztebl.m2023.0243_ref34","doi-asserted-by":"crossref","unstructured":"Goel R, Cushing MM, Tobian AA: Pediatric patient blood management programs: not just transfusing little adults. Transfus Med Rev 2016; 30: 235–41.","DOI":"10.1016\/j.tmrv.2016.07.004"},{"key":"10.3238\/arztebl.m2023.0243_ref35","doi-asserted-by":"crossref","unstructured":"Noland DK, Apelt N, Greenwell C, et al.: Massive transfusion in pediatric trauma: an ATOMAC perspective. J Pediatr Surg 2019; 54: 345–9.","DOI":"10.1016\/j.jpedsurg.2018.10.040"},{"key":"10.3238\/arztebl.m2023.0243_ref36","doi-asserted-by":"crossref","unstructured":"Butler EK, Mills BM, Arbabi S, et al.: Association of blood component ratios with 24-hour mortality in injured children receiving massive transfusion. Crit Care Med 2019; 47: 975–83.","DOI":"10.1097\/CCM.0000000000003708"},{"key":"10.3238\/arztebl.m2023.0243_ref37","unstructured":"Spinella PC, Tucci M, Fergusson DA, et al.: Effect of fresh vs standard-issue red blood cell transfusions on multiple organ dysfunction syndrome in critically ill pediatric patients: a randomized clinical trial. JAMA 2019; 322: 2179–90."},{"key":"10.3238\/arztebl.m2023.0243_ref38","doi-asserted-by":"crossref","unstructured":"Patel RM, Josephson C: Neonatal and pediatric platelet transfusions: current concepts and controversies. Curr Opin Hematol 2019; 26: 466–72.","DOI":"10.1097\/MOH.0000000000000542"},{"key":"10.3238\/arztebl.m2023.0243_ref39","doi-asserted-by":"crossref","unstructured":"Nellis ME, Levasseur J, Stribling J, et al.: Bleeding scales applicable to critically ill children: a systematic review. Pediatr Crit Care Med 2019; 20: 603–7.","DOI":"10.1097\/PCC.0000000000001943"},{"key":"10.3238\/arztebl.m2023.0243_ref40","doi-asserted-by":"crossref","unstructured":"Nellis ME, Karam O, Mauer E, et al.: Platelet transfusion practices in critically ill children. Crit Care Med 2018; 46: 1309–17.","DOI":"10.1097\/CCM.0000000000003192"},{"key":"10.3238\/arztebl.m2023.0243_ref41","doi-asserted-by":"crossref","unstructured":"Saini A, West AN, Harrell C, et al.: Platelet transfusions in the PICU: does disease severity matter? Pediatr Crit Care Med 2018; 19: e472–e8.","DOI":"10.1097\/PCC.0000000000001653"},{"key":"10.3238\/arztebl.m2023.0243_ref42","doi-asserted-by":"crossref","unstructured":"Nellis ME, Goel R, Karam O, et al.: International study of the epidemiology of platelet transfusions in critically ill children with an underlying oncologic diagnosis. Pediatr Crit Care Med 2019; 20: e342–e51.","DOI":"10.1097\/PCC.0000000000001987"},{"key":"10.3238\/arztebl.m2023.0243_ref43","doi-asserted-by":"crossref","unstructured":"Victorino CA, Faria JCP, Suano-Souza FI, Sarni ROS: Evaluation of platelet concentrate prescription in pediatric patients at a tertiary care hospital. Einstein (Sao Paulo) 2019; 17: eAO4720.","DOI":"10.31744\/einstein_journal\/2019AO4720"},{"key":"10.3238\/arztebl.m2023.0243_ref44","doi-asserted-by":"crossref","unstructured":"Resch E, Hinkas O, Urlesberger B, Resch B: Neonatal thrombocytopenia-causes and outcomes following platelet transfusions. Eur J Pediatr 2018; 177: 1045–52.","DOI":"10.1007\/s00431-018-3153-7"},{"key":"10.3238\/arztebl.m2023.0243_ref45","doi-asserted-by":"crossref","unstructured":"Goel R, Josephson CD: Recent advances in transfusions in neonates\/infants. F1000Res 2018; 7: F1000 Faculty Rev-609.","DOI":"10.12688\/f1000research.13979.1"},{"key":"10.3238\/arztebl.m2023.0243_ref46","doi-asserted-by":"crossref","unstructured":"Jensen AK, Ying GS, Huang J, Quinn GE, Binenbaum G: Longitudinal study of the association between thrombocytopenia and retinopathy of prematurity. J AAPOS 2018; 22: 119–23.","DOI":"10.1016\/j.jaapos.2017.11.009"},{"key":"10.3238\/arztebl.m2023.0243_ref47","doi-asserted-by":"crossref","unstructured":"Kumar J, Dutta S, Sundaram V, Saini SS, Sharma RR, Varma N: Platelet transfusion for PDA closure in preterm infants: a randomized controlled trial. Pediatrics 2019; 143: e20182565.","DOI":"10.1542\/peds.2018-2565"},{"key":"10.3238\/arztebl.m2023.0243_ref48","doi-asserted-by":"crossref","unstructured":"Curley A, Venkatesh V, Stanworth S, et al.: Platelets for neonatal transfusion—study 2: a randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. Neonatology 2014; 106: 102–6.","DOI":"10.1159\/000358481"},{"key":"10.3238\/arztebl.m2023.0243_ref49","doi-asserted-by":"crossref","unstructured":"Curley A, Stanworth SJ, Willoughby K, et al.: Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med 2019; 380: 242–51.","DOI":"10.1056\/NEJMoa1807320"},{"key":"10.3238\/arztebl.m2023.0243_ref50","unstructured":"Moore CM, D‘Amore A, Fustolo-Gunnink S, et al.: Two-year outcomes following a randomised platelet transfusion trial in preterm infants. Arch Dis Child Fetal Neonatal Ed 2023; 108: 452–7."}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2023.0243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:42:47Z","timestamp":1705412567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2023.0243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,26]]},"references-count":50,"URL":"https:\/\/doi.org\/10.3238\/arztebl.m2023.0243","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,26]]}}}