{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:10:14Z","timestamp":1765357814842,"version":"3.40.3"},"reference-count":83,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.m2025.0042","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T09:31:02Z","timestamp":1743067862000},"source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic esophagitis: Prevalence, diagnosis, and treatment in childhood and adulthood"],"prefix":"10.3238","author":[{"given":"Andr\u00e9","family":"Hoerning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Oliver","family":"Stei\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Madisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"de Laffolie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"10.3238\/arztebl.m2025.0042_ref1","doi-asserted-by":"crossref","unstructured":"Attwood SEA, Smyrk TC, Demeester TR, Jones JB: Esophageal eosinophilia with dysphagia: a distinct clinicopathologic syndrome. Dig Dis Sci 1993; 38: 109\u201316","DOI":"10.1007\/BF01296781"},{"key":"10.3238\/arztebl.m2025.0042_ref2","unstructured":"Straumann A, Spichtin HP, Bernoulli R, Loosli J, V\u00f6gtlin J: [Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings]. Schweiz Med Wochenschr 1994; 124: 1419\u201329."},{"key":"10.3238\/arztebl.m2025.0042_ref3","doi-asserted-by":"crossref","unstructured":"Dellon ES, Hirano I: Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology 2018; 154: 319\u2013332.e3","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"10.3238\/arztebl.m2025.0042_ref4","doi-asserted-by":"crossref","unstructured":"Giriens B, Yan P, Safroneeva E, et al.: Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993\u20132013: a population-based study. Allergy 2015; 70: 1633\u20139","DOI":"10.1111\/all.12733"},{"key":"10.3238\/arztebl.m2025.0042_ref5","doi-asserted-by":"crossref","unstructured":"Dellon ES, Erichsen R, Baron JA, et al.: The increasing incidence and prevalence of eosinophilic oesophagitis outpaces changes in endoscopic and biopsy practice: national population-based estimates from Denmark. Aliment Pharmacol Ther 2015; 41: 662\u201370","DOI":"10.1111\/apt.13129"},{"key":"10.3238\/arztebl.m2025.0042_ref6","doi-asserted-by":"crossref","unstructured":"Warners MJ, De Rooij W, Van Rhijn BD, et al.: Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20-year results from a nationwide pathology database. Neurogastroenterol Motil 2018; 30: e13165","DOI":"10.1111\/nmo.13165"},{"key":"10.3238\/arztebl.m2025.0042_ref7","doi-asserted-by":"crossref","unstructured":"Arias \u00c1, P\u00e9rez-Mart\u00ednez I, Ten\u00edas JM, Lucendo AJ: Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2016; 43: 3\u201315","DOI":"10.1111\/apt.13441"},{"key":"10.3238\/arztebl.m2025.0042_ref8","doi-asserted-by":"crossref","unstructured":"Navarro P, Arias \u00c1, Arias-Gonz\u00e1lez L, Laserna-Mendieta EJ, Ruiz-Ponce M, Lucendo AJ: Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2019; 49: 1116\u201325","DOI":"10.1111\/apt.15231"},{"key":"10.3238\/arztebl.m2025.0042_ref9","doi-asserted-by":"crossref","unstructured":"Du N, Torres C: Prevalence of eosinophilic gastrointestinal diseases in children with short bowel syndrome: a single center study. J Pediatr Gastroenterol Nutr 2024; 78: 1149\u201354","DOI":"10.1002\/jpn3.12191"},{"key":"10.3238\/arztebl.m2025.0042_ref10","doi-asserted-by":"crossref","unstructured":"Tang TC, Leach ST, Krishnan U: Proton pump inhibitors, antibiotics, and atopy increase the risk of eosinophilic esophagitis in children with esophageal atresia. J Pediatr Gastroenterol Nutr 2024; 78: 1317\u201328","DOI":"10.1002\/jpn3.12129"},{"key":"10.3238\/arztebl.m2025.0042_ref11","doi-asserted-by":"crossref","unstructured":"Capucilli P, Hill DA: Allergic comorbidity in eosinophilic esophagitis: mechanistic relevance and clinical implications. Clin Rev Allergy Immunol 2019; 57: 111\u201327","DOI":"10.1007\/s12016-019-08733-0"},{"key":"10.3238\/arztebl.m2025.0042_ref12","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Cervera J, Arias \u00c1, Redondo-Gonz\u00e1lez O, Cano-Mollinedo MM, Terreehorst I, Lucendo AJ: Association between atopic manifestations and eosinophilic esophagitis. Ann Allergy Asthma Immunol 2017; 118: 582\u2013590.e2","DOI":"10.1016\/j.anai.2017.02.006"},{"key":"10.3238\/arztebl.m2025.0042_ref13","doi-asserted-by":"crossref","unstructured":"Williamson P, Aceves S: Allergies and eosinophilic esophagitis\u2014current updates for the pediatric gastroenterologist. Curr Gastroenterol Rep 2019; 21: 56","DOI":"10.1007\/s11894-019-0729-y"},{"key":"10.3238\/arztebl.m2025.0042_ref14","doi-asserted-by":"crossref","unstructured":"Shook MS, Lu X, Chen X, et al.: Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis. Am J Hum Genet 2024; 111: 280\u201394","DOI":"10.1016\/j.ajhg.2023.12.008"},{"key":"10.3238\/arztebl.m2025.0042_ref15","doi-asserted-by":"crossref","unstructured":"Masuda MY, Pyon GC, Luo H, et al.: Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13. J Allergy Clin Immunol 2024; 153: 1355\u201368","DOI":"10.1016\/j.jaci.2024.01.017"},{"key":"10.3238\/arztebl.m2025.0042_ref16","doi-asserted-by":"crossref","unstructured":"Doyle AD, Masuda MY, Pyon GC, et al.: Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus. Allergy 2023; 78: 192\u2013201","DOI":"10.1111\/all.15457"},{"key":"10.3238\/arztebl.m2025.0042_ref17","doi-asserted-by":"crossref","unstructured":"O\u2019Shea KM, Aceves SS, Dellon ES, et al.: Pathophysiology of eosinophilic esophagitis. Gastroenterology 2018; 154: 333\u201345","DOI":"10.1053\/j.gastro.2017.06.065"},{"key":"10.3238\/arztebl.m2025.0042_ref18","doi-asserted-by":"crossref","unstructured":"Jensen ET, Kuhl JT, Martin LJ, Rothenberg ME, Dellon ES: Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2018; 141: 214\u201322","DOI":"10.1016\/j.jaci.2017.05.018"},{"key":"10.3238\/arztebl.m2025.0042_ref19","doi-asserted-by":"crossref","unstructured":"Hahn JW, Lee K, Shin JI, et al.: Global incidence and prevalence of eosinophilic esophagitis, 1976\u20132022: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2023; 21: 3270\u20133284.e77","DOI":"10.1016\/j.cgh.2023.06.005"},{"key":"10.3238\/arztebl.m2025.0042_ref20","doi-asserted-by":"crossref","unstructured":"Lucendo AJ: Meta-analysis-based guidance for dietary management in eosinophilic esophagitis. Curr Gastroenterol Rep 2015; 17: 37","DOI":"10.1007\/s11894-015-0464-y"},{"key":"10.3238\/arztebl.m2025.0042_ref21","doi-asserted-by":"crossref","unstructured":"Spergel JM, Brown-Whitehorn TF, Cianferoni A, et al.: Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol 2012; 130: 461\u20137","DOI":"10.1016\/j.jaci.2012.05.021"},{"key":"10.3238\/arztebl.m2025.0042_ref22","doi-asserted-by":"crossref","unstructured":"Spergel J, Aceves SS: Allergic components of eosinophilic esophagitis. J Allergy Clin Immunol 2018; 142: 1\u20138","DOI":"10.1016\/j.jaci.2018.05.001"},{"key":"10.3238\/arztebl.m2025.0042_ref23","doi-asserted-by":"crossref","unstructured":"Madisch A, Koop H: Aktualisierung der S2k-Leitlinie Gastro\u00f6sophageale Refluxkrankheit der Deutschen Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). Z F\u00fcr Gastroenterol 2023; 61: 797\u20138","DOI":"10.1055\/a-2060-1142"},{"key":"10.3238\/arztebl.m2025.0042_ref24","doi-asserted-by":"crossref","unstructured":"Furuta GT, Katzka DA: Eosinophilic Esophagitis. N Engl J Med 2015; 373: 1640\u20138","DOI":"10.1056\/NEJMra1502863"},{"key":"10.3238\/arztebl.m2025.0042_ref25","doi-asserted-by":"crossref","unstructured":"Petroni D, Spergel JM: Eosinophilic esophagitis and symptoms possibly related to eosinophilic esophagitis in oral immunotherapy. Ann Allergy Asthma Immunol 2018; 120: 237\u2013240.e4","DOI":"10.1016\/j.anai.2017.11.016"},{"key":"10.3238\/arztebl.m2025.0042_ref26","doi-asserted-by":"crossref","unstructured":"Murray FR, Kreienbuehl AS, Greuter T, et al.: Diagnostic delay in patients with eosinophilic esophagitis has not changed since the first description 30 years ago: Diagnostic delay in eosinophilic esophagitis. Am J Gastroenterol 2022; 117: 1772\u20139","DOI":"10.14309\/ajg.0000000000001950"},{"key":"10.3238\/arztebl.m2025.0042_ref27","doi-asserted-by":"crossref","unstructured":"Oliva S, Dias JA, Rea F, et al.: Characterization of eosinophilic esophagitis from the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN. J Pediatr Gastroenterol Nutr 2022; 75: 325\u201333","DOI":"10.1097\/MPG.0000000000003530"},{"key":"10.3238\/arztebl.m2025.0042_ref28","doi-asserted-by":"crossref","unstructured":"Alexander R, Alexander JA, Ravi K, et al.: Measurement of observed eating behaviors in patients with active and inactive eosinophilic esophagitis. Clin Gastroenterol Hepatol 2019; 17: 2371\u20133","DOI":"10.1016\/j.cgh.2018.12.011"},{"key":"10.3238\/arztebl.m2025.0042_ref29","doi-asserted-by":"crossref","unstructured":"Dhar A, Haboubi HN, Attwood SE, et al.: British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults. Gut 2022; 8: 1459\u201387","DOI":"10.1136\/gutjnl-2022-327326"},{"key":"10.3238\/arztebl.m2025.0042_ref30","doi-asserted-by":"crossref","unstructured":"Klinnert MD, Silveira L, Harris R, et al.: Health related quality of life over time in children with eosinophilic esophagitis and their families. J Pediatr Gastroenterol Nutr 2014; 59: 308\u201316","DOI":"10.1097\/MPG.0000000000000451"},{"key":"10.3238\/arztebl.m2025.0042_ref31","doi-asserted-by":"crossref","unstructured":"Harris RF, Menard-Katcher C, Atkins D, Furuta GT, Klinnert MD: Psychosocial dysfunction in children and adolescents with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2013; 57: 500\u20135","DOI":"10.1097\/MPG.0b013e31829ce5ad"},{"key":"10.3238\/arztebl.m2025.0042_ref32","doi-asserted-by":"crossref","unstructured":"Taft TH, Guadagnoli L, Edlynn E: Anxiety and depression in eosinophilic esophagitis: a scoping review and recommendations for future research. J Asthma Allergy 2019; Volume 12: 389\u201399","DOI":"10.2147\/JAA.S193045"},{"key":"10.3238\/arztebl.m2025.0042_ref33","doi-asserted-by":"crossref","unstructured":"Garc\u00eda Mart\u00ednez De Bartolom\u00e9 R, Barrio Torres J, Sebasti\u00e1n Viana T, et al.: Health related quality of life determinants in Spanish children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2025; 2: 308\u201317","DOI":"10.1002\/jpn3.12426"},{"key":"10.3238\/arztebl.m2025.0042_ref34","doi-asserted-by":"crossref","unstructured":"Gold BD, Goodwin B, Davis K, et al.: Health-related quality of life and perceived stigma in eosinophilic esophagitis: a real-world, US, web-based survey. Gastro Hep Adv 2024; 3: 1087\u201397","DOI":"10.1016\/j.gastha.2024.07.015"},{"key":"10.3238\/arztebl.m2025.0042_ref35","doi-asserted-by":"crossref","unstructured":"\u00d8vlisen AK, Frandsen LT, Holl\u00e6nder M, et al.: Patients with eosinophilic oesophagitis in Denmark have higher use of psychotropic drugs: a Danish nationwide study of psychotropic drug use in 3367 patients and 16,835 matched comparators. United Eur Gastroenterol J 2024; 12: 596\u2013604","DOI":"10.1002\/ueg2.12536"},{"key":"10.3238\/arztebl.m2025.0042_ref36","doi-asserted-by":"crossref","unstructured":"Lorenz P, Koop H, Madisch A, Fischer N, Jansen PL: Leitlinienreport der aktualisierten S2k-Leitlinie Gastro\u00f6sophageale Refluxkrankheit und eosinophile \u00d6sophagitis der Deutschen Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) \u2013 M\u00e4rz 2023 \u2013 AWMF-Registernummer: 021\u2013013. Z F\u00fcr Gastroenterol 2023; 61: e347\u201357","DOI":"10.1055\/a-2060-1188"},{"key":"10.3238\/arztebl.m2025.0042_ref37","doi-asserted-by":"crossref","unstructured":"Amil Dias J, Oliva S, Papadopoulou A, et al.: Diagnosis and management of eosinophilic esophagitis in children: an update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2024; 79: 394\u2013437","DOI":"10.1002\/jpn3.12188"},{"key":"10.3238\/arztebl.m2025.0042_ref38","doi-asserted-by":"crossref","unstructured":"De Bortoli N, Visaggi P, Penagini R, et al.: The 1st EoETALY consensus on the diagnosis and management of eosinophilic esophagitis\u2013current treatment and monitoring. Dig Liver Dis 2024; 56: 1173\u201384","DOI":"10.1016\/j.dld.2024.07.016"},{"key":"10.3238\/arztebl.m2025.0042_ref39","doi-asserted-by":"crossref","unstructured":"Moawad FJ, Molina-Infante J, Lucendo AJ, Cantrell SE, Tmanova L, Douglas KM: Systematic review with meta-analysis: endoscopic dilation is highly effective and safe in children and adults with eosinophilic oesophagitis. Aliment Pharmacol Ther 2017; 46: 96\u2013105","DOI":"10.1111\/apt.14123"},{"key":"10.3238\/arztebl.m2025.0042_ref40","doi-asserted-by":"crossref","unstructured":"Arias \u00c1, Tejera-Mu\u00f1oz A, Guti\u00e9rrez-Ram\u00edrez L, Molina-Infante J, Lucendo AJ, EUREOS Guidelines Committee: Efficacy of dietary therapy for eosinophilic esophagitis in children and adults: an updated systematic review and meta-Analysis. Nutrients 2024; 16: 2231","DOI":"10.3390\/nu16142231"},{"key":"10.3238\/arztebl.m2025.0042_ref41","doi-asserted-by":"crossref","unstructured":"Molina-Infante J, Arias \u00c1, Alcedo J, et al.: Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: the 2\u20134\u20136 study. J Allergy Clin Immunol 2018; 141: 1365\u201372","DOI":"10.1016\/j.jaci.2017.08.038"},{"key":"10.3238\/arztebl.m2025.0042_ref42","unstructured":"Kagalwalla AF, Wechsler JB, Amsden K, et al.: Efficacy of a 4-food elimination diet for children with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2017; 15: 1698\u2013707.e7."},{"key":"10.3238\/arztebl.m2025.0042_ref43","doi-asserted-by":"crossref","unstructured":"Wechsler JB, Schwartz S, Arva NC, et al.: A single-food milk elimination diet is effective for treatment of eosinophilic esophagitis in children. Clin Gastroenterol Hepatol 2022; 20: 1748\u201356.e11","DOI":"10.1016\/j.cgh.2021.03.049"},{"key":"10.3238\/arztebl.m2025.0042_ref44","doi-asserted-by":"crossref","unstructured":"Kliewer KL, Abonia JP, Aceves SS, et al.: One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: a multisite randomized trial. J Allergy Clin Immunol 2025; 155: 520\u201332","DOI":"10.1016\/j.jaci.2024.08.023"},{"key":"10.3238\/arztebl.m2025.0042_ref45","doi-asserted-by":"crossref","unstructured":"Kliewer KL, Venter C, Cassin AM, et al.: Should wheat, barley, rye, and\/or gluten be avoided in a 6-food elimination diet? J Allergy Clin Immunol 2016; 137: 1011\u20134","DOI":"10.1016\/j.jaci.2015.10.040"},{"key":"10.3238\/arztebl.m2025.0042_ref46","doi-asserted-by":"crossref","unstructured":"Kliewer KL, Gonsalves N, Dellon ES, et al.: One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial. Lancet Gastroenterol Hepatol 2023; 8: 408\u201321","DOI":"10.1016\/S2468-1253(23)00012-2"},{"key":"10.3238\/arztebl.m2025.0042_ref47","doi-asserted-by":"crossref","unstructured":"Arias \u00c1, Gonz\u00e1lez-Cervera J, Tenias JM, Lucendo AJ: Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 2014; 146: 1639\u201348","DOI":"10.1053\/j.gastro.2014.02.006"},{"key":"10.3238\/arztebl.m2025.0042_ref48","doi-asserted-by":"crossref","unstructured":"Peterson KA, Byrne KR, Vinson LA, et al.: Elemental diet induces histologic response in adult eosinophilic esophagitis. Am J Gastroenterol 2013; 108: 759\u201366","DOI":"10.1038\/ajg.2012.468"},{"key":"10.3238\/arztebl.m2025.0042_ref49","doi-asserted-by":"crossref","unstructured":"Robson J, Laborda T, Fitzgerald S, et al.: Avoidant\/restrictive food intake disorder in diet-treated children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2019; 69: 57\u201360","DOI":"10.1097\/MPG.0000000000002323"},{"key":"10.3238\/arztebl.m2025.0042_ref50","doi-asserted-by":"crossref","unstructured":"Molina-Infante J: Nutritional and psychological considerations for dietary therapy in eosinophilic esophagitis. Nutrients 2022; 14: 1588","DOI":"10.3390\/nu14081588"},{"key":"10.3238\/arztebl.m2025.0042_ref51","doi-asserted-by":"crossref","unstructured":"Franciosi JP, Mougey EB, Dellon ES, et al.: Proton pump inhibitor therapy for eosinophilic esophagitis: history, mechanisms, efficacy, and future directions. J Asthma Allergy 2022; 15: 281\u2013302","DOI":"10.2147\/JAA.S274524"},{"key":"10.3238\/arztebl.m2025.0042_ref52","doi-asserted-by":"crossref","unstructured":"Barchi A, Massimino L, Mandarino FV, et al.: Clinical, histological and safety outcomes with long-term maintenance therapies for eosinophilic esophagitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2024; S1542\u20133565: 01069\u20133","DOI":"10.1016\/j.cgh.2024.11.007"},{"key":"10.3238\/arztebl.m2025.0042_ref53","doi-asserted-by":"crossref","unstructured":"Liu X, Xiao X, Liu D, Tan C: A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide. Ann Med 2022; 54: 2078\u201388","DOI":"10.1080\/07853890.2022.2101689"},{"key":"10.3238\/arztebl.m2025.0042_ref54","doi-asserted-by":"crossref","unstructured":"Dellon ES, Katzka DA, Collins MH, et al.: Safety and efficacy of budesonide oral suspension maintenance therapy in patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2019; 17: 666\u201373.e8","DOI":"10.1016\/j.cgh.2018.05.051"},{"key":"10.3238\/arztebl.m2025.0042_ref55","doi-asserted-by":"crossref","unstructured":"Miehlke S, Hruz P, Vieth M, et al.: A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis. Gut 2016; 65: 390\u20139","DOI":"10.1136\/gutjnl-2014-308815"},{"key":"10.3238\/arztebl.m2025.0042_ref56","doi-asserted-by":"crossref","unstructured":"Golekoh MC, Hornung LN, Mukkada VA, Khoury JC, Putnam PE, Backeljauw PF: Adrenal insufficiency after chronic swallowed glucocorticoid therapy for eosinophilic esophagitis. J Pediatr 2016; 170: 240\u20135","DOI":"10.1016\/j.jpeds.2015.11.026"},{"key":"10.3238\/arztebl.m2025.0042_ref57","doi-asserted-by":"crossref","unstructured":"Butz BK, Wen T, Gleich GJ, et al.: Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology 2014; 147: 324\u201333.e5. e18","DOI":"10.1053\/j.gastro.2014.04.019"},{"key":"10.3238\/arztebl.m2025.0042_ref58","doi-asserted-by":"crossref","unstructured":"Oliva S, Rossetti D, Papoff P, et al.: A 12-week maintenance therapy with a new prepared viscous budesonide in pediatric eosinophilic esophagitis. Dig Dis Sci 2019; 64: 1571\u20138","DOI":"10.1007\/s10620-018-5449-x"},{"key":"10.3238\/arztebl.m2025.0042_ref59","doi-asserted-by":"crossref","unstructured":"Rothenberg ME, Dellon ES, Collins MH, et al.: Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Gastroenterol Hepatol 2023; 8: 990\u20131004","DOI":"10.1016\/S2468-1253(23)00204-2"},{"key":"10.3238\/arztebl.m2025.0042_ref60","doi-asserted-by":"crossref","unstructured":"Bredenoord AJ, Dellon ES, Hirano I, et al.: Dupilumab demonstrated efficacy and was well tolerated regardless of prior use of swallowed topical corticosteroids in adolescent and adult patients with eosinophilic oesophagitis: a subgroup analysis of the phase 3 LIBERTY EoE TREET study. Gut 2024; 73: 398\u2013406","DOI":"10.1136\/gutjnl-2023-330220"},{"key":"10.3238\/arztebl.m2025.0042_ref61","doi-asserted-by":"crossref","unstructured":"Chehade M, Dellon ES, Spergel JM, et al.: Dupilumab for eosinophilic esophagitis in patients 1 to 11 years of age. N Engl J Med 2024; 390: 2239\u201351.","DOI":"10.1056\/NEJMoa2312282"},{"key":"10.3238\/arztebl.m2025.0042_ref62","doi-asserted-by":"crossref","unstructured":"Dellon ES, Rothenberg ME, Collins MH, et al.: Dupilumab in adults and adolescents with eosinophilic esophagitis. N Engl J Med 2022; 387: 2317\u201330.","DOI":"10.1056\/NEJMoa2205982"},{"key":"10.3238\/arztebl.m2025.0042_ref63","doi-asserted-by":"crossref","unstructured":"Rothenberg ME, Dellon ES, Collins MH, et al.: Eosinophil depletion with benralizumab for eosinophilic esophagitis. N Engl J Med 2024; 390: 2252\u201363.","DOI":"10.1056\/NEJMoa2313318"},{"key":"10.3238\/arztebl.m2025.0042_ref64","doi-asserted-by":"crossref","unstructured":"Schoepfer AM, Safroneeva E: Pharmacologic treatment of eosinophilic esophagitis: efficacious, likely efficacious, and failed drugs. Inflamm Intest Dis 2024; 9: 199\u2013209.","DOI":"10.1159\/000540275"},{"key":"10.3238\/arztebl.m2025.0042_ref65","doi-asserted-by":"crossref","unstructured":"Biedermann L, Schlag C, Straumann A, et al.: Efficacy and safety of budesonide orodispersible tablets for eosinophilic esophagitis up to 3 years: an open-label extension study. Clin Gastroenterol Hepatol 2024; S1542\u20133565: 01088\u20137.","DOI":"10.1016\/j.cgh.2024.10.034"},{"key":"10.3238\/arztebl.m2025.0042_ref66","doi-asserted-by":"crossref","unstructured":"Molina-Infante J, Rodriguez-Sanchez J, Martinek J, et al.: Long-term loss of response in proton pump inhibitor-responsive esophageal eosinophilia is uncommon and influenced by CYP2C19 genotype and rhinoconjunctivitis. Am J Gastroenterol 2015; 110: 1567\u201375.","DOI":"10.1038\/ajg.2015.314"},{"key":"10.3238\/arztebl.m2025.0042_ref67","doi-asserted-by":"crossref","unstructured":"Lucendo AJ, Arias \u00c1, Gonz\u00e1lez-Cervera J, et al.: Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol 2013; 131: 797\u2013804.","DOI":"10.1016\/j.jaci.2012.12.664"},{"key":"10.3238\/arztebl.m2025.0042_ref68","doi-asserted-by":"crossref","unstructured":"Gonsalves N, Yang G, Doerfler B, Ritz S, Ditto AM, Hirano I: Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012; 142: 1451\u20139.e1.","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"10.3238\/arztebl.m2025.0042_ref69","doi-asserted-by":"crossref","unstructured":"Lee CJ, Dellon ES: Real-world efficacy of dupilumab in severe, treatment-refractory, and fibrostenotic patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2024; 22: 252\u20138.","DOI":"10.1016\/j.cgh.2023.08.015"},{"key":"10.3238\/arztebl.m2025.0042_ref70","doi-asserted-by":"crossref","unstructured":"Russin M, Chen J, Rubenstein JH, Chang JW: Real-world effectiveness and use of dupilumab in eosinophilic esophagitis. Am J Gastroenterol 2025; 120: 663\u201366.","DOI":"10.14309\/ajg.0000000000003087"},{"key":"10.3238\/arztebl.m2025.0042_ref71","doi-asserted-by":"crossref","unstructured":"Hirano I, Furuta GT: Approaches and challenges to management of pediatric and adult patients with eosinophilic esophagitis. Gastroenterology 2020; 158: 840\u201351.","DOI":"10.1053\/j.gastro.2019.09.052"},{"key":"10.3238\/arztebl.m2025.0042_ref72","doi-asserted-by":"crossref","unstructured":"Kumar S, Choi SS, Gupta SK: Eosinophilic esophagitis: current status and future directions. Pediatr Res 2020; 88: 345\u20137.","DOI":"10.1038\/s41390-020-0770-4"},{"key":"10.3238\/arztebl.m2025.0042_ref73","unstructured":"Straumann A, Lucendo AJ, Miehlke S, et al.: Budesonide orodispersible tablets maintain remission in a randomized, placebo-controlled trial of patients with eosinophilic esophagitis. Gastroenterology 2020; 159: 1672\u201385.e5."},{"key":"10.3238\/arztebl.m2025.0042_ref74","unstructured":"Lucendo AJ, Miehlke S, Schlag C, et al.: Efficacy of budesonide orodispersible tablets as induction therapy for eosinophilic esophagitis in a randomized placebo-controlled trial. Gastroenterology 2019; 157: 74\u201386.e15."},{"key":"10.3238\/arztebl.m2025.0042_ref75","doi-asserted-by":"crossref","unstructured":"Hirano I, Collins MH, Katzka DA, et al.: Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial. Clin Gastroenterol Hepatol 2022; 20: 525\u201334.e10.","DOI":"10.1016\/j.cgh.2021.04.022"},{"key":"10.3238\/arztebl.m2025.0042_ref76","doi-asserted-by":"crossref","unstructured":"Sawas T, Dhalla S, Sayyar M, Pasricha PJ, Hernaez R: Systematic review with meta-analysis: pharmacological interventions for eosinophilic oesophagitis. Aliment Pharmacol Ther 2015; 41: 797\u2013806.","DOI":"10.1111\/apt.13147"},{"key":"10.3238\/arztebl.m2025.0042_ref77","doi-asserted-by":"crossref","unstructured":"Dellon ES, Woosley JT, Arrington A, et al.: Efficacy of budesonide vs fluticasone for initial treatment of eosinophilic esophagitis in a randomized controlled trial. Gastroenterology 2019; 157: 65\u201373.e5.","DOI":"10.1053\/j.gastro.2019.03.014"},{"key":"10.3238\/arztebl.m2025.0042_ref78","doi-asserted-by":"crossref","unstructured":"Dellon ES, Sheikh A, Speck O, et al.: Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis. Gastroenterology 2012; 143: 321\u20134.e1.","DOI":"10.1053\/j.gastro.2012.04.049"},{"key":"10.3238\/arztebl.m2025.0042_ref79","doi-asserted-by":"crossref","unstructured":"Schroeder S, Fleischer DM, Masterson JC, Gelfand E, Furuta GT, Atkins D: Successful treatment of eosinophilic esophagitis with ciclesonide. J Allergy Clin Immunol 2012; 129: 1419\u201321.","DOI":"10.1016\/j.jaci.2012.03.007"},{"key":"10.3238\/arztebl.m2025.0042_ref80","doi-asserted-by":"crossref","unstructured":"Straumann A, Conus S, Degen L, et al.: Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2011; 9: 400\u20139.e1.","DOI":"10.1016\/j.cgh.2011.01.017"},{"key":"10.3238\/arztebl.m2025.0042_ref81","doi-asserted-by":"crossref","unstructured":"Rank MA, Sharaf RN, Furuta GT, et al.: Technical review on the management of eosinophilic esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters. Gastroenterology 2020; 158: 1789\u2013810.e15.","DOI":"10.1053\/j.gastro.2020.02.039"},{"key":"10.3238\/arztebl.m2025.0042_ref82","doi-asserted-by":"crossref","unstructured":"Lucendo AJ, Arias \u00c1, Molina-Infante J: Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016; 14: 13\u201322.e1.","DOI":"10.1016\/j.cgh.2015.07.041"},{"key":"10.3238\/arztebl.m2025.0042_ref83","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Junquera C, Fern\u00e1ndez-Fern\u00e1ndez S, Cilleruelo ML, et al.: High prevalence of response to proton-pump inhibitor treatment in children with esophageal eosinophilia. J Pediatr Gastroenterol Nutr 2016; 62: 704\u201310.","DOI":"10.1097\/MPG.0000000000001019"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T09:33:55Z","timestamp":1743068035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":83,"URL":"https:\/\/doi.org\/10.3238\/arztebl.m2025.0042","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}