{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:52:47Z","timestamp":1758055967174,"version":"3.44.0"},"reference-count":32,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.m2025.0107","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:28:08Z","timestamp":1757669288000},"source":"Crossref","is-referenced-by-count":0,"title":["Single-shot perioperative antibiotic prophylaxis in patients with a history of penicillin allergy"],"prefix":"10.3238","author":[{"given":"Anne","family":"R\u00fcggeberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Lommel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Tiedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"10.3238\/arztebl.m2025.0107_ref1","unstructured":"Deutsche Gesellschaft f\u00fcr Hygiene und Mikrobiologie e. V. (Hrsg.): S3-Leitlinie Perioperative und Periinterventionelle Antibiotikaprophylaxe \u2013 Aktualisierung 2024. Langversion, 5.0. AWMF Registernummer: 067\/009, verf\u00fcgbar unter https:\/\/register.awmf.org\/de\/leitlinien\/detail\/067-009 (last accessed on 15 July \/2025)."},{"key":"10.3238\/arztebl.m2025.0107_ref2","doi-asserted-by":"crossref","unstructured":"Luintel A, Healy J, Blank M, et al.: The global prevalence of reported penicillin allergy: A systematic review and meta-analysis. J Infect 2025; 90: 106429","DOI":"10.1016\/j.jinf.2025.106429"},{"key":"10.3238\/arztebl.m2025.0107_ref3","doi-asserted-by":"crossref","unstructured":"Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC: Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis. Allergy 2017; 72: 1288\u201396","DOI":"10.1111\/all.13168"},{"key":"10.3238\/arztebl.m2025.0107_ref4","doi-asserted-by":"crossref","unstructured":"Blumenthal KG, Ryan EE, Li Y, Lee H, Kuhlen JL, Shenoy ES: The impact of a reported penicillin allergy on surgical site infection risk. Clin Infect Dis 2018; 66: 329\u201336","DOI":"10.1093\/cid\/cix794"},{"key":"10.3238\/arztebl.m2025.0107_ref5","doi-asserted-by":"crossref","unstructured":"Nieboer M, Braig Z, Rosenow C, et al.: Non-cefazolin antibiotic prophylaxis is associated with higher rates of elbow periprosthetic joint infection. J Shoulder Elbow Surg 2024; 33: 940\u20137","DOI":"10.1016\/j.jse.2023.10.029"},{"key":"10.3238\/arztebl.m2025.0107_ref6","doi-asserted-by":"crossref","unstructured":"Macy E, Contreras R: Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: A cohort study. J Allergy Clin Immunol 2014; 133: 790\u20136","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"10.3238\/arztebl.m2025.0107_ref7","doi-asserted-by":"crossref","unstructured":"Roebke AJ, Malik AT, Khan SN, Yu E: Does a reported penicillin allergy affect outcomes following elective posterior lumbar fusions? Int J Spine Surg 2022; 16: 1023\u20138","DOI":"10.14444\/8326"},{"key":"10.3238\/arztebl.m2025.0107_ref8","doi-asserted-by":"crossref","unstructured":"Wu VJ, Iloanya MC, Sanchez FL, et al.: Is patient-reported penicillin allergy independently associated with increased risk of prosthetic joint infection after total joint arthroplasty of the hip, knee, and shoulder? Clin Orthop Related Res 2020; 478: 2699\u2013709","DOI":"10.1097\/CORR.0000000000001497"},{"key":"10.3238\/arztebl.m2025.0107_ref9","doi-asserted-by":"crossref","unstructured":"Raso J, Kamalapathy PN, Puvanesarajah V, Labaran L, Hassanzadeh H: Penicillin allergy in spine surgery: Increased rates of sepsis, emergency room visits, and readmission. World Neurosurg 2022; 162: e91\u2013e8","DOI":"10.1016\/j.wneu.2022.02.079"},{"key":"10.3238\/arztebl.m2025.0107_ref10","doi-asserted-by":"crossref","unstructured":"Leis JA, Evans GA, Ciccotelli W, et al.: Choosing wisely Canada \u2013 top five list in infectious diseases: An official position statement of the Association of Medical Microbiology and Infectious Disease (AMMI) Canada. J Assoc Med Microbiol Infect Dis Can 2018; 3: 61\u201370","DOI":"10.3138\/jammi.2018.02.08"},{"key":"10.3238\/arztebl.m2025.0107_ref11","doi-asserted-by":"crossref","unstructured":"Fernandez J, Jimenez-Rodriguez TW, Blanca-Lopez N: Classifying cephalosporins: From generation to cross-reactivity. Curr Opin Allergy Clin Immunol 2021; 21: 346\u201354","DOI":"10.1097\/ACI.0000000000000755"},{"key":"10.3238\/arztebl.m2025.0107_ref12","doi-asserted-by":"crossref","unstructured":"Trubiano JA, Stone CA, Grayson ML, et al.: The 3 Cs of antibiotic allergy\u2014classification, cross-reactivity, and collaboration. J Allergy Clin Immunol Pract 2017; 5: 1532\u201342","DOI":"10.1016\/j.jaip.2017.06.017"},{"key":"10.3238\/arztebl.m2025.0107_ref13","doi-asserted-by":"crossref","unstructured":"Romano A, Gaeta F, Poves MFA, Valluzzi RL: Cross-reactivity among beta-lactams. Curr Allergy Asthma Rep 2016; 16: 24","DOI":"10.1007\/s11882-016-0594-9"},{"key":"10.3238\/arztebl.m2025.0107_ref14","doi-asserted-by":"crossref","unstructured":"Romano A, Valluzzi RL, Caruso C, Maggioletti M, Quaratino D, Gaeta F: Cross-reactivity and tolerability of cephalosporins in patients with IgE-mediated hypersensitivity to penicillins. J Allergy Clin Immunol Pract 2018; 6: 1662\u201372","DOI":"10.1016\/j.jaip.2018.01.020"},{"key":"10.3238\/arztebl.m2025.0107_ref15","doi-asserted-by":"crossref","unstructured":"Sousa-Pinto B, Blumenthal KG, Courtney L, Mancini CM, Jeffres MN: Assessment of the frequency of dual allergy to penicillins and cefazolin: A systematic review and meta-analysis. JAMA Surg 2021; 156: e210021","DOI":"10.1001\/jamasurg.2021.0021"},{"key":"10.3238\/arztebl.m2025.0107_ref16","doi-asserted-by":"crossref","unstructured":"Wijnakker R, Van Maaren MS, Bode LGM, et al.: The dutch working party on antibiotic policy (SWAB) guideline for the approach to suspected antibiotic allergy. Clin Microbiol Infect 2023; 29: 863\u201375","DOI":"10.1016\/j.cmi.2023.04.008"},{"key":"10.3238\/arztebl.m2025.0107_ref17","unstructured":"Wacha H, Hoyme U, Isenmann R, et al.: Perioperative antibiotika-prophylaxe. ."},{"key":"10.3238\/arztebl.m2025.0107_ref18","doi-asserted-by":"crossref","unstructured":"Taylor MJ, McNicholas C, Nicolay C, Darzi A, Bell D, Reed JE: Systematic review of the application of the plan\u2013do\u2013study\u2013act method to improve quality in healthcare. BMJ Qual Saf 2014; 23: 290\u20138","DOI":"10.1136\/bmjqs-2013-001862"},{"key":"10.3238\/arztebl.m2025.0107_ref19","doi-asserted-by":"crossref","unstructured":"Wurpts G, Aberer W, Dickel H, et al.: S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-\u00dcberempfindlichkeit: Leitlinie der Deutschen Gesellschaft f\u00fcr Allergologie und klinische Immunologie (DGAKI) in Zusammenarbeit mit dem \u00c4rzteverband Deutscher Allergologen (AeDA), der Gesellschaft f\u00fcr P\u00e4diatrische Allergologie und Umweltmedizin (GPA), der Deutschen Kontaktallergiegruppe (DKG), der \u00d6sterreichischen Gesellschaft f\u00fcr Allergologie und Immunologie (\u00d6GAI) und der Paul-Ehrlich-Gesellschaft f\u00fcr Chemotherapie (PEG). Allergo J Int 2019; 28: 121\u201351","DOI":"10.1007\/s15007-019-1876-z"},{"key":"10.3238\/arztebl.m2025.0107_ref20","doi-asserted-by":"crossref","unstructured":"Strom BL, Schinnar R, Apter AJ, et al.: Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med 2003; 349: 1628\u201335","DOI":"10.1056\/NEJMoa022963"},{"key":"10.3238\/arztebl.m2025.0107_ref21","doi-asserted-by":"crossref","unstructured":"Trubiano JA, Vogrin S, Chua KYL, et al.: Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med 2020; 180: 745\u201352","DOI":"10.1001\/jamainternmed.2020.0403"},{"key":"10.3238\/arztebl.m2025.0107_ref22","doi-asserted-by":"crossref","unstructured":"Vorobeichik L, Weber EA, Tarshis J: Misconceptions surrounding penicillin allergy: Implications for anesthesiologists. Anesth Analg 2018; 127: 642\u20139","DOI":"10.1213\/ANE.0000000000003419"},{"key":"10.3238\/arztebl.m2025.0107_ref23","doi-asserted-by":"crossref","unstructured":"Blumenthal KG, Li Y, Hsu JT, et al.: Outcomes from an inpatient beta-lactam allergy guideline across a large US health system. Infect Control Hosp Epidemiol 2019; 40: 528\u201335","DOI":"10.1017\/ice.2019.50"},{"key":"10.3238\/arztebl.m2025.0107_ref24","doi-asserted-by":"crossref","unstructured":"Shenoy ES, Macy E, Rowe T, Blumenthal KG: Evaluation and management of penicillin allergy: A review. JAMA 2019; 321: 188\u201399","DOI":"10.1001\/jama.2018.19283"},{"key":"10.3238\/arztebl.m2025.0107_ref25","doi-asserted-by":"crossref","unstructured":"Castells M, Khan DA, Phillips EJ: Penicillin Allergy. N Engl J Med 2019; 381: 2338\u201351","DOI":"10.1056\/NEJMra1807761"},{"key":"10.3238\/arztebl.m2025.0107_ref26","doi-asserted-by":"crossref","unstructured":"Kaminsky LW, Ghahramani A, Hussein R, Al-Shaikhly T: Penicillin allergy label is associated with worse clinical outcomes in bacterial pneumonia. J Allergy Clin Immunol Pract 2022; 10: 3262\u20139","DOI":"10.1016\/j.jaip.2022.08.027"},{"key":"10.3238\/arztebl.m2025.0107_ref27","doi-asserted-by":"crossref","unstructured":"Charneski L, Deshpande G, Smith SW: Impact of an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. Pharmacotherapy 2011; 31: 742\u20137","DOI":"10.1592\/phco.31.8.742"},{"key":"10.3238\/arztebl.m2025.0107_ref28","doi-asserted-by":"crossref","unstructured":"West RM, Smith CJ, Pavitt SH, et al.: \u2018Warning: allergic to penicillin\u2019: Association between penicillin allergy status in 2.3 million NHS general practice electronic health records, antibiotic prescribing and health outcomes. J Antimicrob Chemother 2019; 74: 2075\u201382","DOI":"10.1093\/jac\/dkz127"},{"key":"10.3238\/arztebl.m2025.0107_ref29","doi-asserted-by":"crossref","unstructured":"Baiardini I, Gaeta F, Molinengo G, Braido F, Canonica GW, Romano A: Quality-of-life issues in survivors to anaphylactic reactions to drugs. Allergy 2015; 70: 877\u20139","DOI":"10.1111\/all.12610"},{"key":"10.3238\/arztebl.m2025.0107_ref30","doi-asserted-by":"crossref","unstructured":"Jeffres MN, Narayanan PP, Shuster JE, Schramm GE: Consequences of avoiding β-lactams in patients with β-lactam allergies. J Allergy Clin Immunol 2016; 137: 1148\u201353","DOI":"10.1016\/j.jaci.2015.10.026"},{"key":"10.3238\/arztebl.m2025.0107_ref31","doi-asserted-by":"crossref","unstructured":"Lang DM, Castells MC, Khan DA, Macy EM, Murphy AW: Penicillin allergy testing should be performed routinely in patients with self-reported penicillin allergy. J Allergy Clin Immunol Pract 2017; 5: 333\u20134","DOI":"10.1016\/j.jaip.2016.12.010"},{"key":"10.3238\/arztebl.m2025.0107_ref32","doi-asserted-by":"crossref","unstructured":"Liu MY, Challa M, McCoul ED, Chen PG: Economic viability of penicillin allergy testing to avoid improper clindamycin surgical prophylaxis. Laryngoscope 2023; 133: 1086\u201391","DOI":"10.1002\/lary.30329"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T09:38:23Z","timestamp":1757929103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":32,"URL":"https:\/\/doi.org\/10.3238\/arztebl.m2025.0107","relation":{},"ISSN":["1866-0452"],"issn-type":[{"type":"electronic","value":"1866-0452"}],"subject":[],"published":{"date-parts":[[2025,9,19]]}}}