{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:03:57Z","timestamp":1759190637341,"version":"3.44.0"},"reference-count":32,"publisher":"Deutscher Arzte-Verlag GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3238\/arztebl.m2025.0126","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T06:35:51Z","timestamp":1759127751000},"source":"Crossref","is-referenced-by-count":0,"title":["Triage of stable patients with suspected acute myocardial infarction and left bundle branch block"],"prefix":"10.3238","author":[{"given":"Sascha","family":"Macherey-Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Heyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max Maria","family":"Meertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Finke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Terporten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Michael","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Horlitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Malte","family":"Sinning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Rosswinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11437","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"10.3238\/arztebl.m2025.0126_ref1","doi-asserted-by":"crossref","unstructured":"Byrne RA, Rossello X, Coughlan JJ, et al.: 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J 2023; 44: 3720\u20136","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"10.3238\/arztebl.m2025.0126_ref2","doi-asserted-by":"crossref","unstructured":"Stenestrand U, Tabrizi F, Lindback J, Englund A, Rosenqvist M, Wallentin L: Comorbidity and myocardial dysfunction are the main explanations for the higher 1-year mortality in acute myocardial infarction with left bundle-branch block. Circulation 2004; 110: 1896\u2013902","DOI":"10.1161\/01.CIR.0000143136.51424.38"},{"key":"10.3238\/arztebl.m2025.0126_ref3","doi-asserted-by":"crossref","unstructured":"Yeo KK, Li S, Amsterdam EA, et al.: Comparison of clinical characteristics, treatments and outcomes of patients with ST-elevation acute myocardial infarction with versus without new or presumed new left bundle branch block (from NCDR(R)). Am J Cardiol 2012; 109: 497\u2013501","DOI":"10.1016\/j.amjcard.2011.09.040"},{"key":"10.3238\/arztebl.m2025.0126_ref4","doi-asserted-by":"crossref","unstructured":"Sgarbossa EB, Pinski SL, Topol EJ, et al.: Acute myocardial infarction and complete bundle branch block at hospital admission: Clinical characteristics and outcome in the thrombolytic era. GUSTO-I Investigators. Global utilization of streptokinase and t-PA [tissue-type plasminogen activator] for occluded coronary arteries. J Am Coll Cardiol 1998; 31: 105\u201310","DOI":"10.1016\/S0735-1097(97)00446-4"},{"key":"10.3238\/arztebl.m2025.0126_ref5","doi-asserted-by":"crossref","unstructured":"Neeland IJ, Kontos MC, de Lemos JA: Evolving considerations in the management of patients with left bundle branch block and suspected myocardial infarction. J Am Coll Cardiol 2012; 60: 96\u2013105","DOI":"10.1016\/j.jacc.2012.02.054"},{"key":"10.3238\/arztebl.m2025.0126_ref6","doi-asserted-by":"crossref","unstructured":"Nestelberger T, Cullen L, Lindahl B, et al.: Diagnosis of acute myocardial infarction in the presence of left bundle branch block. Heart 2019; 105: 1559\u201367","DOI":"10.1136\/heartjnl-2018-314673"},{"key":"10.3238\/arztebl.m2025.0126_ref7","doi-asserted-by":"crossref","unstructured":"Al-Faleh H, Fu Y, Wagner G, et al.: Unraveling the spectrum of left bundle branch block in acute myocardial infarction: Insights from the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT 2 and 3) trials. Am Heart J 2006; 151: 10\u20135","DOI":"10.1016\/j.ahj.2005.02.043"},{"key":"10.3238\/arztebl.m2025.0126_ref8","doi-asserted-by":"crossref","unstructured":"Gulati M, Levy PD, Mukherjee D, et al.: 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR Guideline for the evaluation and diagnosis of chest pain: Executive summary: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2021; 144: e368-e454","DOI":"10.1161\/CIR.0000000000001030"},{"key":"10.3238\/arztebl.m2025.0126_ref9","doi-asserted-by":"crossref","unstructured":"Go AS, Barron HV, Rundle AC, Ornato JP, Avins AL: Bundle-branch block and in-hospital mortality in acute myocardial infarction. National Registry of Myocardial Infarction 2 Investigators. Ann Intern Med 1998; 129: 690\u20137","DOI":"10.7326\/0003-4819-129-9-199811010-00003"},{"key":"10.3238\/arztebl.m2025.0126_ref10","doi-asserted-by":"crossref","unstructured":"Bansilal S, Aneja A, Mathew V, et al.: Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block. Am J Cardiol 2011; 107: 1565\u201370","DOI":"10.1016\/j.amjcard.2011.01.039"},{"key":"10.3238\/arztebl.m2025.0126_ref11","doi-asserted-by":"crossref","unstructured":"Jain S, Ting HT, Bell M, et al.: Utility of left bundle branch block as a diagnostic criterion for acute myocardial infarction. Am J Cardiol 2011; 107: 1111\u20136","DOI":"10.1016\/j.amjcard.2010.12.007"},{"key":"10.3238\/arztebl.m2025.0126_ref12","doi-asserted-by":"crossref","unstructured":"S\u00f6rensen NA, Fakhri Y, Gossling A, et al.: Impact of quantitative ST-T analysis in patients with suspected myocardial infarction presenting with right bundle branch block. Am J Med 2024; 137: 770\u20135.e1","DOI":"10.1016\/j.amjmed.2024.04.021"},{"key":"10.3238\/arztebl.m2025.0126_ref13","doi-asserted-by":"crossref","unstructured":"Larson DM, Menssen KM, Sharkey SW, et al.: \u201eFalse-positive\u201c cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction. JAMA 2007; 298: 2754\u201360","DOI":"10.1001\/jama.298.23.2754"},{"key":"10.3238\/arztebl.m2025.0126_ref14","doi-asserted-by":"crossref","unstructured":"Mehta N, Huang HD, Bandeali S, Wilson JM, Birnbaum Y: Prevalence of acute myocardial infarction in patients with presumably new left bundle-branch block. J Electrocardiol 2012; 45: 361\u20137","DOI":"10.1016\/j.jelectrocard.2012.04.006"},{"key":"10.3238\/arztebl.m2025.0126_ref15","doi-asserted-by":"crossref","unstructured":"Meyers HP, Limkakeng AT, Jr., Jaffa EJ, et al.: Validation of the modified Sgarbossa criteria for acute coronary occlusion in the setting of left bundle branch block: A retrospective case-control study. Am Heart J 2015; 170: 1255\u201364","DOI":"10.1016\/j.ahj.2015.09.005"},{"key":"10.3238\/arztebl.m2025.0126_ref16","doi-asserted-by":"crossref","unstructured":"Di Marco A, Rodriguez M, Cinca J, et al.: New electrocardiographic algorithm for the diagnosis of acute myocardial infarction in patients with left bundle branch block. J Am Heart Assoc 2020; 9: e015573","DOI":"10.1161\/JAHA.119.015573"},{"key":"10.3238\/arztebl.m2025.0126_ref17","doi-asserted-by":"crossref","unstructured":"Smith SW, Dodd KW, Henry TD, Dvorak DM, Pearce LA: Diagnosis of ST-elevation myocardial infarction in the presence of left bundle branch block with the ST-elevation to S-wave ratio in a modified Sgarbossa rule. Ann Emerg Med 2012; 60: 766\u201376","DOI":"10.1016\/j.annemergmed.2012.07.119"},{"key":"10.3238\/arztebl.m2025.0126_ref18","doi-asserted-by":"crossref","unstructured":"Sgarbossa EB, Pinski SL, Barbagelata A, et al.: Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block. GUSTO-1 (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries) investigators. N Engl J Med 1996; 334: 481\u20137","DOI":"10.1056\/NEJM199602223340801"},{"key":"10.3238\/arztebl.m2025.0126_ref19","doi-asserted-by":"crossref","unstructured":"Lindow T, Mokhtari A, Nystrom A, Koul S, Smith SW, Ekelund U: Comparison of diagnostic accuracy of current left bundle branch block and ventricular pacing ECG criteria for detection of occlusion myocardial infarction. Int J Cardiol 2024; 395: 131569","DOI":"10.1016\/j.ijcard.2023.131569"},{"key":"10.3238\/arztebl.m2025.0126_ref20","doi-asserted-by":"crossref","unstructured":"Erne P, Iglesias JF, Urban P, et al: Left bundle-branch block in patients with acute myocardial infarction: Presentation, treatment, and trends in outcome from 1997 to 2016 in routine clinical practice. Am Heart J 2017; 184: 106\u201313","DOI":"10.1016\/j.ahj.2016.11.003"},{"key":"10.3238\/arztebl.m2025.0126_ref21","doi-asserted-by":"crossref","unstructured":"Macherey S, Meertens MM, Adler C, et al.: Impact of respiratory infectious epidemics on STEMI incidence and care. Sci Rep 2021; 11: 23066","DOI":"10.1038\/s41598-021-02480-z"},{"key":"10.3238\/arztebl.m2025.0126_ref22","doi-asserted-by":"crossref","unstructured":"Pfister R, Lee S, Kuhr K, et al.: Impact of the type of first medical contact within a guideline-conform ST-elevation myocardial infarction network: A prospective observational registry study. PLoS One 2016; 11: e0156769","DOI":"10.1371\/journal.pone.0156769"},{"key":"10.3238\/arztebl.m2025.0126_ref23","doi-asserted-by":"crossref","unstructured":"Flesch M, Hagemeister J, Berger HJ, et al.: Implementation of guidelines for the treatment of acute ST-elevation myocardial infarction: the Cologne Infarction Model Registry. Circ Cardiovasc Interv 2008; 1: 95\u2013102","DOI":"10.1161\/CIRCINTERVENTIONS.108.768176"},{"key":"10.3238\/arztebl.m2025.0126_ref24","doi-asserted-by":"crossref","unstructured":"Turer AT, Mahaffey KW, Gallup D, et al.: Enzyme estimates of infarct size correlate with functional and clinical outcomes in the setting of ST-segment elevation myocardial infarction. Curr Control Trials Cardiovasc Med 2005; 6: 12","DOI":"10.1186\/1468-6708-6-12"},{"key":"10.3238\/arztebl.m2025.0126_ref25","doi-asserted-by":"crossref","unstructured":"Kontos MC, Aziz HA, Chau VQ, Roberts CS, Ornato JP, Vetrovec GW: Outcomes in patients with chronicity of left bundle-branch block with possible acute myocardial infarction. Am Heart J 2011; 161: 698\u2013704","DOI":"10.1016\/j.ahj.2011.01.008"},{"key":"10.3238\/arztebl.m2025.0126_ref26","doi-asserted-by":"crossref","unstructured":"Wegmann C, Pfister R, Scholz S, et al.: [Diagnostic value of left bundle branch block in patients with acute myocardial infarction. A prospective analysis]. Herz 2015; 40: 1107\u201314","DOI":"10.1007\/s00059-015-4326-z"},{"key":"10.3238\/arztebl.m2025.0126_ref27","doi-asserted-by":"crossref","unstructured":"Kite TA, Kurmani SA, Bountziouka V, et al.: Timing of invasive strategy in non-ST-elevation acute coronary syndrome: A meta-analysis of randomized controlled trials. Eur Heart J 2022; 43: 3148\u201361","DOI":"10.1093\/eurheartj\/ehac213"},{"key":"10.3238\/arztebl.m2025.0126_ref28","doi-asserted-by":"crossref","unstructured":"Heyne S, Macherey S, Meertens MM, et al.: Coronary angiography after cardiac arrest without ST-elevation myocardial infarction: A network meta-analysis. Eur Heart J 2023; 44: 1040\u201354","DOI":"10.1093\/eurheartj\/ehac611"},{"key":"10.3238\/arztebl.m2025.0126_ref29","doi-asserted-by":"crossref","unstructured":"Birnbaum Y, Ye Y, Smith SW, Jneid H: Rapid diagnosis of STEMI equivalent in patients with left bundle-branch block: Is it feasible? J Am Heart Assoc 2021; 10: e023275","DOI":"10.1161\/JAHA.121.023275"},{"key":"10.3238\/arztebl.m2025.0126_ref30","doi-asserted-by":"crossref","unstructured":"de Alencar Neto JN, Scheffer MK, Correia BP, Franchini KG, Felicioni SP, De Marchi MFN: Systematic review and meta-analysis of diagnostic test accuracy of ST-segment elevation for acute coronary occlusion. Int J Cardiol 2024; 402: 131889","DOI":"10.1016\/j.ijcard.2024.131889"},{"key":"10.3238\/arztebl.m2025.0126_ref31","unstructured":"Nestelberger T, Boeddinghaus J, Lopez Ayala P, et al.: Utility of echocardiography in patients with suspected acute myocardial infarction and left bundle-branch block. J Am Heart Assoc 2021; 10: e021262"},{"key":"10.3238\/arztebl.m2025.0126_ref32","doi-asserted-by":"crossref","unstructured":"Thygesen K, Alpert JS, Jaffe AS, et al.: Fourth universal definition of myocardial infarction (2018). Circulation 2018; 138: e618\u2013e51","DOI":"10.1161\/CIR.0000000000000617"}],"container-title":["Deutsches \u00c4rzteblatt international"],"original-title":[],"link":[{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T06:35:58Z","timestamp":1759127758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerzteblatt.de\/10.3238\/arztebl.m2025.0126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":32,"URL":"https:\/\/doi.org\/10.3238\/arztebl.m2025.0126","relation":{},"ISSN":["1866-0452"],"issn-type":[{"value":"1866-0452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]}}}