{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T08:25:50Z","timestamp":1744446350931},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>OBJECTIVES<\/strong>. The use of effective combinated antiretroviral therapy has significantly improved the prognosis\u00a0of patients with HIV infection. Although current antiretroviral regimens are very effective in inhibiting viral\u00a0replication, its elimination is not a viable goal of treatment. Despite cART, non\u2013AIDS-defining bacterial\u00a0infections are still a serious problem. The spectrum of these infections, and in particular the proportion of\u00a0particular bacterial pathogens, is not sufficiently described in the scientific literature.<br \/><strong>METHODS<\/strong>. In the study, HIV-infected patients followed at the HIV Out-Patient Clinic in Warsaw were registered\u00a0in the clinic from 1 January 2007 to 31 July 2016. Survival analysis included 558 patients who met the study criteria.<br \/><strong>RESULTS<\/strong>. Among 251 (44.9%) of those with positive culture, the most common bacterial pathogen was\u00a0Staphylococcus aureus (33%) and Escherichia coli (11.1%). The most common bacteria in the upper respiratory\u00a0tract was Staphylococcus aureus (26.6%). In urine cultures the most common bacteria was Escherichia coli\u00a0(9.5%). Staphylococcus aureus (2.3%) and Staphylococcus epidermidis (2.3%) were the most common bacterial\u00a0cultures in the wound. In skin cultures the most common bacteria was Staphylococcus aureus (3.9%). The\u00a0highest number of positive cultures was obtained from the upper respiratory tract -166 (66.1%).<br \/><strong>CONCLUSION<\/strong>. Non\u2013AIDS-defining bacterial infections are a common clinical problem in HIV-infected patients\u00a0despite the introduction of antiretroviral therapy and the pathogens that cause these infections are a very diverse group.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>CELE<\/strong>. Zastosowanie skutecznej terapii antyretrowirusowej znacz\u0105co poprawi\u0142o rokowanie chorych zaka\u017conych\u00a0HIV. Chocia\u017c obecne schematy terapii antyretrowirusowej s\u0105 bardzo skuteczne w hamowaniu replikacji\u00a0wirusa, to jego eliminacja nie jest mo\u017cliwym osi\u0105galnym celem leczenia. Pomimo cART, zaka\u017cenia bakteryjne\u00a0niedefiniuj\u0105ce AIDS pozostaj\u0105 powa\u017cnym problemem. Spektrum tych zaka\u017ce\u0144, a w szczeg\u00f3lno\u015bci udzia\u0142\u00a0poszczeg\u00f3lnych patogen\u00f3w bakteryjnych nie jest dostatecznie opisany w literaturze naukowej.<br \/><strong>METODY<\/strong>. W wykonanym badaniu obserwowano pacjent\u00f3w zaka\u017conych HIV, znajduj\u0105cych si\u0119 pod opiek\u0105\u00a0specjalistyczn\u0105 Poradni Profilaktyczno-Leczniczej w Warszawie, zarejestrowanych w poradni od 1 stycznia\u00a02007 roku do 31 lipca 2016 roku. Do analizy prze\u017cycia w\u0142\u0105czono 558 pacjent\u00f3w spe\u0142niaj\u0105cych kryteria badania.<br \/><strong>WYNIKI<\/strong>. W\u015br\u00f3d 251 (44,9%) os\u00f3b z dodatnimi posiewami najbardziej powszechnym patogenem bakteryjnym by\u0142\u00a0Staphylococcus aureus (33%,) oraz Escherichia coli (11,1%), przy czym w posiewach z g\u00f3rnych dr\u00f3g oddechowych\u00a0najcz\u0119\u015bciej hodowano Staphylococcus aureus (26,6%), w posiewach moczu najcz\u0119stsz\u0105 stwierdzan\u0105 bakteri\u0105 by\u0142a\u00a0Escherichia coli (9,5%), w posiewach z rany najcz\u0119\u015bciej hodowan\u0105 bakteri\u0105 by\u0142 Staphylococcus aureus (2,3%)\u00a0i Staphylococcus epidermidis (2,3%) a w posiewach sk\u00f3ry w wyhodowanych bakteriach przewa\u017ca\u0142 Staphylococcus\u00a0aureus (3,9%). Najwi\u0119ksz\u0105 ilo\u015b\u0107 dodatnich posiew\u00f3w uzyskano z g\u00f3rnych dr\u00f3g oddechowych -166 (66,1%) posiew\u00f3w.<br \/><strong>WNIOSKI<\/strong>. Zaka\u017cenia bakteryjne niedefiniuj\u0105ce AIDS s\u0105 cz\u0119stym problemem klinicznym u pacjent\u00f3w z zaka\u017ceniem\u00a0HIV mimo wprowadzenia terapii antyretrowirusowej, a patogeny wywo\u0142uj\u0105ce te zaka\u017cenia stanowi\u0105\u00a0bardzo r\u00f3\u017cnorodn\u0105 grup\u0119.<\/p><\/jats:p>","DOI":"10.32394\/pe.73.48","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T14:29:58Z","timestamp":1582727398000},"page":"511-521","source":"Crossref","is-referenced-by-count":2,"title":["Non-AIDS defining bacterial infections in patients with HIV infection"],"prefix":"10.32394","volume":"73","author":[{"given":"A","family":"Skrzat-Klapaczy\u0144ska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Kowalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Mat\u0142osz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bednarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Paciorek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Horban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2020,1,15]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Zaka\u017cenia bakteryjne niedefiniuj\u0105ce AIDS u pacjent\u00f3w z zakazeniem HIV"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180907-101464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180907-101464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:46:13Z","timestamp":1709887573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Non-AIDS-defining-bacterial-infections-in-patients-with-HIV-infection,180907,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"alternative-id":["180907"],"URL":"https:\/\/doi.org\/10.32394\/pe.73.48","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}