{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:07:10Z","timestamp":1767773230012},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>BACKGROUND.<\/strong> <em>Clostridium difficile<\/em> infections become a serious problem in terms of nosocomial infections,\u00a0as well as a consequence of common use of antibiotics.<br \/><strong>AIM.<\/strong> The aim of the study was to evaluate <em>Clostridium difficile<\/em> carriage in patients admitted to the Clinical\u00a0Department of Infectious Diseases and Hepatology without acute or chronic diarrhea and to assess the impact of\u00a0antibiotic treatment on the development of enteritis in hospital. Other factors that may affect the risk of infection\u00a0were also analyzed.<br \/><strong>RESULTS.<\/strong> Fourteen patients (14%) were carriers of <em>Clostridium difficile<\/em> at admission. Second assessment\u00a0taken after fourteen days of antibiotic treatment showed decrease in GDH antigen prevalence to eight subjects\u00a0(12.1%). Three patients (3%) had diarrhea during hospitalization, and the toxins A and\/or B were found in them.<br \/><strong>CONCLUSIONS.<\/strong> The frequency of <em>Clostridium difficile<\/em> carriage among adults in Poland may be underestimated.<br \/>Screening for <em>Clostridium difficile<\/em> GDH antigen may be useful although do not provide definite prognosis of\u00a0symptomatic disease during ceftriaxone treatment. The risk of <em>Clostridium difficile<\/em> infection may be reduced\u00a0mainly by rationalizing antibiotic therapy and following appropriate procedures.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>WST\u0118P.<\/strong> Zaka\u017cenia <em>Clostridium difficile<\/em> staj\u0105 si\u0119 coraz powa\u017cniejszym problemem w aspekcie zaka\u017ce\u0144 wewn\u0105trzszpitalnych,\u00a0a tak\u017ce jako konsekwencja powszechnego stosowania antybiotyk\u00f3w.<br \/><strong>CEL PRACY.<\/strong> Celem pracy by\u0142o oszacowanie nosicielstwa <em>Clostridium difficile<\/em> w populacji chorych przyjmowanych\u00a0do Oddzia\u0142u Klinicznego Chor\u00f3b Zaka\u017anych i Hepatologii bez cech ostrej lub przewlek\u0142ej choroby biegunkowej\u00a0i ocena wp\u0142ywu antybiotykoterapii na rozw\u00f3j zapalenia jelit w warunkach szpitalnych. Analizowano\u00a0tak\u017ce inne czynniki mog\u0105ce mie\u0107 wp\u0142yw na ryzyko zaka\u017cenia.<br \/><strong>WYNIKI.<\/strong> W chwili przyj\u0119cia 14 (14%) chorych by\u0142o nosicielami <em>C. difficile.<\/em> W badaniu kontrolnym wykonanym\u00a0po 14 dniach leczenia antybiotykami obserwowano zmniejszenie cz\u0119sto\u015bci dodatniego wyniku badania\u00a0GDH do 8 os\u00f3b (12,1%). U trzech os\u00f3b (3%) w trakcie leczenia wyst\u0105pi\u0142a biegunka, a badaniami stolca wykazano\u00a0obecno\u015b\u0107 toksyny A i\/lub B C. difficile.<br \/><strong>WNIOSKI.<\/strong> Cz\u0119sto\u015b\u0107 nosicielstwa <em>C. difficile<\/em> w grupie os\u00f3b doros\u0142ych w Polsce mo\u017ce by\u0107 niedoszacowana.<br \/>Badania przesiewowe w kierunku obecno\u015bci antygenu GDH <em>C. difficile<\/em> mog\u0105 by\u0107 przydatne, ale nie pozwalaj\u0105\u00a0jednoznacznie prognozowa\u0107 rozwoju objawowej choroby w trakcie leczenia ceftriaksonem. Ryzyko CDI mo\u017cna\u00a0ograniczy\u0107 przede wszystkim poprzez racjonalizacj\u0119 antybiotykoterapii i przestrzeganie odpowiednich procedur.<\/p><\/jats:p>","DOI":"10.32394\/pe.74.01","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T12:36:40Z","timestamp":1591965400000},"page":"3-10","source":"Crossref","is-referenced-by-count":2,"title":["Clinical significance of asymptomatic Clostridium difficile colonisation in patients undergoing antibiotic treatment"],"prefix":"10.32394","volume":"74","author":[{"given":"W","family":"Stolarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Piotrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"B\u0142aszkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Oczko-Grzesik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jaroszewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"K\u0119pa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Sobala-Szczygie\u0142","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Piasecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boro\u0144-Kaczmarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2020,5,27]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Znaczenie kliniczne nosicielstwa Clostridium difficile u chorych poddawanych antybiotykoterapii"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180916-101479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180916-101479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:45:36Z","timestamp":1709887536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Clinical-significance-of-asymptomatic-Clostridium-difficile-colonisation-in-patients,180916,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["180916"],"URL":"https:\/\/doi.org\/10.32394\/pe.74.01","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]}}}