{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:49:27Z","timestamp":1762033767000,"version":"build-2065373602"},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>BACKGROUND.<\/strong> After the introduction of rotavirus vaccines into immunization schedules, noroviruses\u00a0account for the majority of acute gastrointestinal infections. The aim of the study was to assess the clinical\u00a0presentation in immunocompromised and immunocompetent children with hospital- and community-acquired\u00a0norovirus gastroenteritis.<br \/><strong>MATERIAL AND METHODS.<\/strong> We retrospectively reviewed clinical records of children with noroviral\u00a0gastroenteritis, hospitalized in the Pediatric Hospital, Medical University of Warsaw, between 2015 and 2018.\u00a0Acute gastrointestinal tract symptoms and confirmed etiology of noroviral infection were inclusion criteria.<br \/>The analysis was performed in the subgroups of immunocompetent and immunocompromised patients, during\u00a0community-acquired and nosocomial infections.<br \/><strong>RESULTS.<\/strong> A total of 57 children with median age 1.5 year (IQR: 0.7-4.0) were recruited. The majority of\u00a0patients were immunocompetent (87.7%), and nosocomial infections were predominant (56.1%). Gastrointestinal\u00a0symptoms included nausea, vomiting and diarrhoea (in approximately 85%), while systemic manifestations such\u00a0as fever and malaise where observed in only \u00bc. Routine laboratory tests were normal in most of the patients. An\u00a0analysis in the subgroups revealed statistically significant differences in blood pH and serum electrolyte levels\u00a0- acidosis and electrolyte disturbances were statistically significantly more common in immunocompromised vs\u00a0immunocompetent patients (p<0.05).<br \/><strong>CONCLUSIONS.<\/strong> More frequently the clinical presentation includes gastrointestinal symptoms with no\u00a0differences between immunocompromised and immunocompetent hosts. The median laboratory values were\u00a0normal in generally healthy children; disturbances were observed only in children with immunodeficiencies.\u00a0Therefore, prophylactic measures are of particular importance in the latter group, which is especially sensitive to\u00a0severe and nosocomial infections.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>WST\u0118P.<\/strong> Po wprowadzeniu szczepionek przeciwko rotawirusom do program\u00f3w szczepie\u0144 ochronnych norowirusy\u00a0zacz\u0119\u0142y odpowiada\u0107 za wi\u0119kszo\u015b\u0107 ostrych infekcji \u017co\u0142\u0105dkowo-jelitowych. Celem badania by\u0142a ocena\u00a0obrazu klinicznego pozaszpitalnych i wewn\u0105trzszpitalnych zaka\u017ce\u0144 przewodu pokarmowego wywo\u0142anych przez\u00a0norowirusy u dzieci z prawid\u0142ow\u0105 oraz obni\u017con\u0105 odporno\u015bci\u0105.<br \/><strong>MATERIA\u0141 I METODY.<\/strong> Analizie retrospektywnej poddano dane kliniczne dzieci z ostrym nie\u017cytem \u017co\u0142\u0105dka\u00a0i jelit, hospitalizowanych w Szpitalu Pediatrycznym Warszawskiego Uniwersytetu Medycznego w latach 2015-2018. Kryteriami w\u0142\u0105czenia by\u0142y ostre objawy ze strony przewodu pokarmowego i potwierdzona etiologia infekcji\u00a0norowirusowej. Analiz\u0119 przeprowadzono w podgrupach pacjent\u00f3w z prawid\u0142ow\u0105 i z obni\u017con\u0105 odporno\u015bci\u0105,\u00a0w przebiegu zaka\u017ce\u0144 pozaszpitalnych i wewn\u0105trzszpitalnych.<br \/><strong>WYNIKI.<\/strong> Zrekrutowano og\u00f3\u0142em 57 dzieci, \u015brednia wieku wynosi\u0142a 1,5 roku (IQR: 0,7-4,0). Wi\u0119kszo\u015b\u0107 pacjent\u00f3w\u00a0by\u0142a immunokompetentna (87,7%), przewa\u017ca\u0142y zaka\u017cenia szpitalne (56,1%). Objawy \u017co\u0142\u0105dkowo-jelitowe\u00a0obejmowa\u0142y nudno\u015bci, wymioty i biegunk\u0119 (u oko\u0142o 85%), a objawy og\u00f3lnoustrojowe, takie jak gor\u0105czka i z\u0142e\u00a0samopoczucie, obserwowano tylko u \u00bc pacjent\u00f3w. Podstawowe badania laboratoryjne by\u0142y w zakresie warto\u015bci\u00a0prawid\u0142owych u wi\u0119kszo\u015bci pacjent\u00f3w. Analiza w podgrupach wykaza\u0142a istotne statystycznie r\u00f3\u017cnice w: pH\u00a0krwi oraz w poziomach elektrolit\u00f3w w surowicy - kwasica i zaburzenia elektrolitowe by\u0142y statystycznie istotnie\u00a0cz\u0119stsze u pacjent\u00f3w z obni\u017con\u0105 odporno\u015bci\u0105 ni\u017c u pacjent\u00f3w z prawid\u0142ow\u0105 odporno\u015bci\u0105 (p <0,05).<br \/><strong>WNIOSKI.<\/strong> Najcz\u0119\u015bciej obraz kliniczny zaka\u017ce\u0144 norowirusowych obejmuje objawy ze strony przewodu pokarmowego,\u00a0bez r\u00f3\u017cnic pomi\u0119dzy chorymi z prawid\u0142ow\u0105 i obni\u017con\u0105 odporno\u015bci\u0105. Wyniki bada\u0144 laboratoryjnych\u00a0by\u0142y w normie u og\u00f3lnie zdrowych dzieci; zaburzenia obserwowano tylko u dzieci z niedoborami odporno\u015bci.\u00a0Z tego powodu \u015brodki zapobiegawcze maj\u0105 szczeg\u00f3lne znaczenie w drugiej grupie pacjent\u00f3w, wyj\u0105tkowo wra\u017cliwej\u00a0na ci\u0119\u017cki przebieg infekcji oraz cz\u0119stsze zaka\u017cenia wewn\u0105trzszpitalne.<\/p><\/jats:p>","DOI":"10.32394\/pe.74.03","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T12:36:48Z","timestamp":1591965408000},"page":"23-31","source":"Crossref","is-referenced-by-count":4,"title":["The clinical course of gastroenteritis due to nosocomial and community acquired norovirus infections in immunocompromised and immunocompetent children \u2013 single center experience"],"prefix":"10.32394","volume":"74","author":[{"given":"A","family":"Za\u0142\u0119ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Banasiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Karpierz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kuchar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Podsiad\u0142y","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2020,5,27]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Przebieg kliniczny szpitalnych i pozaszpitalnych zaka\u017ce\u0144 norowirusowy"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180918-101481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180918-101481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:45:40Z","timestamp":1709887540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/The-clinical-course-of-gastroenteritis-due-to-nosocomial-and-community-acquired-norovirus,180918,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["180918"],"URL":"https:\/\/doi.org\/10.32394\/pe.74.03","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"type":"print","value":"0033-2100"},{"type":"electronic","value":"2545-1898"}],"subject":[],"published":{"date-parts":[[2020,5,27]]}}}