{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T10:21:19Z","timestamp":1751797279630},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>BACKGROUND.<\/strong> Immunosuppressed patients, also those who are HIV-positive patients, are susceptible to oral\u00a0cavity fungal infections.<br \/><strong>AIM OF STUDY.<\/strong> In this study, we aimed to show differences in qualitative composition of oral cavity flora\u00a0between HIV-positive people and healthy controls and identify factors which affect fungal oral cavity flora.<br \/><strong>MATERIALS AND METHODS.<\/strong> The study group contained HIV-positive people and a control group of\u00a0healthy people. All cultured species were analysed using MALDI-TOF MS.<br \/><strong>RESULTS.<\/strong> More HIV-positive people had two or more fungus species present than controls (p=0.008). Seven\u00a0species were cultured in the study group compared to three in the control group. Smoking was associated with\u00a0higher prevalence of C. albicans (p=0.03), C. glabrata (p=0.026), C. tropicalis (p=0.01). Dental prosthesis or\u00a0braces was also associated with presence of more species (p=0.04).The lower level of lymphocytes CD4+ was\u00a0not associated with fungus presence in oral cavity.<br \/><strong>CONCLUSIONS.<\/strong> HIV infection is associated with changes to oral cavity fungal flora. Given the higher number\u00a0of non-albicans species among HIV-positive patients it is important to individually choose a treatment for such\u00a0patients\u2019 fungal infections. Proper oral hygene and not smoking can reduce prevalence of fungi in oral cavity. Patients\u2019\u00a0immunological status did not have an impact on the frequency of Candida species isolation from the oral cavity.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>WST\u0118P.<\/strong> Pacjenci z immunosupresj\u0105, tak\u017ce ci zaka\u017ceni HIV, s\u0105 szczeg\u00f3lnie podatni na infekcje grzybicze jamy\u00a0ustnej.<br \/><strong>CEL PRACY.<\/strong> Badanie mia\u0142o na celu ukazanie r\u00f3\u017cnic w sk\u0142adzie jako\u015bciowym flory jamy ustnej os\u00f3b HIV-dodatnich i u os\u00f3b zdrowych z grupy kontrolnej oraz zidentyfikowanie czynnik\u00f3w wp\u0142ywaj\u0105cych na obecno\u015b\u0107 i sk\u0142ad flory grzybiczej jamy ustnej.<br \/><strong>MATERIA\u0141Y I METODY.<\/strong> Grup\u0119 badan\u0105 stanowi\u0142y osoby zaka\u017cone HIV, a grup\u0119 kontroln\u0105 stanowi\u0142y osoby zdrowe. Wszystkie wyhodowane szczepy grzybicze zosta\u0142y poddane analizie gatunkowej przy pomocy metody\u00a0diagnostycznej MALDI-TOF MS.<br \/><strong>WYNIKI.<\/strong> Wyst\u0119powanie dw\u00f3ch lub wi\u0119cej gatunk\u00f3w grzyb\u00f3w w jamie ustnej stwierdzono cz\u0119\u015bciej u os\u00f3b\u00a0zaka\u017conych HIV w por\u00f3wnaniu z grup\u0105 kontroln\u0105 (p=0,008). W grupie badanej wyhodowano siedem gatunk\u00f3w\u00a0grzyb\u00f3w, natomiast w grupie kontrolnej jedynie trzy gatunki. Palenie papieros\u00f3w by\u0142o zwi\u0105zane z cz\u0119stszym\u00a0wyst\u0119powaniem gatunk\u00f3w C. albicans (p=0,03), C. glabrata (p=0,026), C. tropicalis (p=0,01). Obecno\u015b\u0107 protezy\u00a0z\u0119bowej lub aparatu ortodontycznego by\u0142a zwi\u0105zana z obecno\u015bci\u0105 wi\u0119kszej liczby gatunk\u00f3w w jamie ustnej\u00a0(p=0,04). Obni\u017cony poziom limfocyt\u00f3w CD4+ nie mia\u0142 wp\u0142ywu na cz\u0119stsze wyst\u0119powanie grzyb\u00f3w w sk\u0142adzie\u00a0flory jamy ustnej.<br \/><strong>WNIOSKI.<\/strong> Zaka\u017cenie HIV jest zwi\u0105zane ze zmianami sk\u0142adu flory grzybiczej jamy ustnej. Z powodu cz\u0119stszej\u00a0izolacji gatunk\u00f3w non-albicans po\u015br\u00f3d HIV-dodatnich pacjent\u00f3w, istotne jest aby indywidualnie dobiera\u0107 terapi\u0119\u00a0dla tych pacjent\u00f3w w przypadku infekcji grzybiczych. Odpowiednia higiena jamy ustnej oraz zaprzestanie palenia\u00a0mog\u0105 zredukowa\u0107 wyst\u0119powanie grzyb\u00f3w w jamie ustnej. Status immunologiczny pacjenta nie ma wp\u0142ywu\u00a0na obecno\u015b\u0107 grzyb\u00f3w we florze jamy ustnej.<\/p><\/jats:p>","DOI":"10.32394\/pe.74.04","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T12:36:51Z","timestamp":1591965411000},"page":"33-42","source":"Crossref","is-referenced-by-count":3,"title":["Oral cavity fungal flora among HIV-positive people"],"prefix":"10.32394","volume":"74","author":[{"given":"Sz","family":"Andrusi\u00f3w","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Zendram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Paj\u0105czkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Janczura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Inglot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2020,5,27]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Flora grzybicza jamy ustnej u pacjent\u00f3w zaka\u017conych HIV"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180919-101482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180919-101482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:45:41Z","timestamp":1709887541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Oral-cavity-fungal-flora-among-HIV-positive-people,180919,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["180919"],"URL":"https:\/\/doi.org\/10.32394\/pe.74.04","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]}}}