{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:17:22Z","timestamp":1755796642862},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>BACKGROUND.<\/strong> Pemphigus is a group of potentially fatal dermatological autoimmune disorders.\u00a0<br \/><strong>AIM.<\/strong> Analysis of cases of pemphigus vulgaris (PV) and pemphigus foliaceus (PF) newly diagnosed and treated\u00a0at the Department of Dermatology and Venereology, Medical University of Bia\u0142ystok, North-east Poland in\u00a0years 2001-2018.<br \/><strong>MATERIAL AND METHODS.<\/strong> A retrospective analysis and comparison of sociodemographic, epidemiological\u00a0and clinical characteristics of PV and PF patients, including: age, gender, residency, initial severity of skin\u00a0lesions, involvement of mucous membranes, co-morbidities and their treatment, efficacy of therapy.<br \/><strong>RESULTS.<\/strong> Sixty-two new cases \u2013 41 (66.13%) of PV and 21 (33.87%) of PF were diagnosed. The average age\u00a0of PV patients was 54.85\u00b112.35 years and those of PF \u2013 63.81\u00b131.52 years, P<0.05. Females constituted 75.61%\u00a0and 61.90% in PV and PF group, respectively. Majority of patients with PV were residents of urban and these\u00a0with PF \u2013 of rural areas (70.73% and 66.67%, respectively). On admission, 14 patients with PV (34.15%) and\u00a011 with PF (52.38%) had more than 30% of body surface area involved. In 22 (53.66%) PV mucous membrane\u00a0(oropharyngeal cavity) was involved. Ten (24.39%) patients with PV and 12 (57.14%) - with PF had more than one\u00a0concomitant disorder (P<0.05). In treatment prednisone in monotherapy or with additional immunosuppressive\u00a0agent was mainly used. The disease relapsed within three years after achieving clinical and immunological\u00a0remission in 29.27% of PV and in 38.10% of PF patients.<br \/><strong>CONCLUSIONS.<\/strong> PF patients are older than PV ones, more frequently live in rural areas, have more comorbidities.<br \/>Females constitute majority of pemphigus patients. The disease may relapse in about one third of\u00a0patients. Because of frequent comorbidities, also these related to pemphigus treatment, patients with pemphigus\u00a0require complex and multispecialistic medical care.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>WST\u0118P.<\/strong> P\u0119cherzyce s\u0105 grup\u0105 potencjalnie \u015bmiertelnych autoimmunologicznych schorze\u0144 dermatologicznych.<br \/><strong>CEL.<\/strong> Analiza przypadk\u00f3w p\u0119cherzycy zwyk\u0142ej (pemphigus vulgaris \u2013 PV) i p\u0119cherzycy li\u015bciastej (pemphigus\u00a0foliaceus \u2013 PF) zdiagnozowanych i leczonych w Klinice Dermatologii i Wenerologii Uniwersytetu Medycznego\u00a0w Bia\u0142ymstoku w latach 2001-2018.<br \/><strong>MATERIA\u0141 I METODY.<\/strong> Retrospektywna analiza i por\u00f3wnanie danych socjodemograficznych, epidemiologicznych\u00a0i klinicznych pacjent\u00f3w z PV i PF, z uwzgl\u0119dnieniem wieku, p\u0142ci, miejsca zamieszkania, rozleg\u0142o\u015bci\u00a0zmian sk\u00f3rnych, zaj\u0119cia b\u0142on \u015bluzowych, schorze\u0144 wsp\u00f3\u0142istniej\u0105cych i przyjmowanych lek\u00f3w, skuteczno\u015bci\u00a0terapii.<br \/><strong>WYNIKI.<\/strong> Rozpoznano 62 nowe przypadki p\u0119cherzycy \u2013 41 (66,13%) PV and 21 (33,87%) PF. \u015aredni wiek pacjent\u00f3w z PV wynosi\u0142 54,85\u00b112,35 roku a z PF \u2013 63,81\u00b131,52 roku (p<0,05). Kobiety stanowi\u0142y odpowiednio\u00a075,61% i 61,90% w grupie PV i PF. Wi\u0119kszo\u015b\u0107 pacjent\u00f3w z PV mieszka\u0142o w miastach, a z PF \u2013 na wsi (odpowiednio 70,73% i 66, 67%). Ponad 30% powierzchni sk\u00f3ry zaj\u0119tej zmianami chorobowymi mia\u0142o 14 (34,15%)<br \/>pacjent\u00f3w z PV i 11 (52,38%) z PF. Zaj\u0119cie b\u0142on \u015bluzowych jamy ustnej stwierdzono u 22 (53,66%) pacjent\u00f3w\u00a0z PV. Wi\u0119cej ni\u017c jedno schorzenie wsp\u00f3\u0142istniej\u0105ce z p\u0119cherzyc\u0105 mia\u0142o 10 pacjent\u00f3w (24,39%) z PV i 12 (57,14%)\u00a0z PF, p<0,05. W leczeniu stosowano g\u0142\u00f3wnie prednizon w monoterapii lub razem z innymi lekami immunosupresyjnymi.<br \/>Choroba nawr\u00f3ci\u0142a w ci\u0105gu trzech lat po osi\u0105gni\u0119ciu remisji klinicznej i immunologicznej u 29,27%\u00a0pacjent\u00f3w z PV i 38,10% - z PF.<br \/><strong>WNIOSKI.<\/strong> Pacjenci z PF s\u0105 starsi ni\u017c z PV, cz\u0119\u015bciej mieszkaj\u0105 na terenach wiejskich, maj\u0105 wi\u0119cej schorze\u0144\u00a0wsp\u00f3\u0142istniej\u0105cych. Kobiety stanowi\u0105 wi\u0119kszo\u015b\u0107 chorych z p\u0119cherzyc\u0105. U jednej trzeciej pacjent\u00f3w choroba\u00a0mo\u017ce nawr\u00f3ci\u0107. Ze wzgl\u0119du na cz\u0119ste inne schorzenia, w tym powi\u0105zane z leczeniem p\u0119cherzycy, pacjenci ci\u00a0wymagaj\u0105 z\u0142o\u017conej i wielospecjalistycznej opieki medycznej.<\/p><\/jats:p>","DOI":"10.32394\/pe.74.39","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T09:46:14Z","timestamp":1617356774000},"page":"457-465","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiological and clinical characteristics of patients with pemphigus treated in Bia\u0142ystok in 2001-2018"],"prefix":"10.32394","volume":"74","author":[{"given":"A B","family":"Serwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Flisiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2021,1,13]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Epidemiologiczna i kliniczna charakterystyka pacjent\u00f3w z p\u0119cherzyc\u0105 leczonych w O\u015brodku Bia\u0142ostockim w latach 2001-2018"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180954-101517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180954-101517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:45:34Z","timestamp":1709887534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Epidemiological-and-clinical-characteristics-of-patients-with-pemphigus-treated-in,180954,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"alternative-id":["180954"],"URL":"https:\/\/doi.org\/10.32394\/pe.74.39","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]}}}