{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T09:11:58Z","timestamp":1709889118353},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/>Actinomycosis is one of the greatest \u2018chameleons\u2019 among infectious diseases. It may imitate inflammation,\u00a0abscess or a neoplasmatic tumor. Moreover, correct diagnosis is even more challenging due to the fact that the\u00a0disease takes on various forms like: cervicocephalic, abdominal, or affects the reproductive organs. In order to\u00a0highlight the diagnostic difficulties of actinomycosis, we have decided to describe six cases of female patients\u00a0(aged 31-73 years, mean age: 52 years) hospitalized due to actinomycosis in the Department of Infectious Diseases\u00a0and Hepatology between 2014-2019. Additionally, a case of one patient was described in detail as the course\u00a0of her disease was exceptionally non-specific. Only in 2 of 6 patients the primary diagnosis was correct. The\u00a0four other patients were initially suspected with cancer or inflammation. Three of the patients were diagnosed\u00a0with the abdominal form of actinomycosis, one \u2013 neck and head, and one presented both locations. Only\u00a0histopathological examinations during invasive procedures allowed to state the final diagnosis. An adequate\u00a0diagnosis was associated with a number of additional tests and delayed appropriate treatment. WBC and CRP\u00a0were within normal range in all patients. Four patients completed treatment successfully after 60-192 days, one\u00a0is still on therapy and one is lost to follow-up. In conclusion, common features of actinomycosis presented in this\u00a0case series include predominance of female gender, abdominal localization and lack of typical symptoms. What\u00a0is more, therapy with antibiotics, mainly doxycycline and beta-lactams resulted in complete regression of lesions\u00a0in the majority of cases. Given the examples of our patients we believe that actinomycosis should be considered\u00a0in the differential diagnosis of all abdominal tumors, especially in women.<\/p>\n<p><strong>Abbreviations:<\/strong> WBC \u2013 white blood cells, CRP \u2013 C-reactive protein, CT \u2013 computed tomography, IUD - Intra-Uterine Device, i.v. - intravenous.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/>Promienica to najwi\u0119kszy \u201ckameleon\u201d w\u015br\u00f3d chor\u00f3b zaka\u017anych - mo\u017ce na\u015bladowa\u0107 zapalenie, ropie\u0144,\u00a0a nawet nowotw\u00f3r. Postawienie prawid\u0142owej diagnozy jest wymagaj\u0105ce ze wzgl\u0119du na fakt, \u017ce choroba\u00a0ta wyst\u0119puje w wielu postaciach: twarzowo-szyjnej, brzusznej, b\u0105d\u017a w obr\u0119bie miednicy mniejszej.<br \/>W latach 2014 - 2019 w naszym Oddziale z powodu aktynomykozy hospitalizowano 6 pacjentek pomi\u0119dzy 31.\u00a0a 72. r.\u017c.. Przypadek jednej z pacjentek jest opisany szczeg\u00f3\u0142owo w niniejszej pracy ze wzgl\u0119du na nietypowy\u00a0przebieg choroby. Jedynie u dw\u00f3ch z sze\u015bciu pacjentek pierwotna diagnoza by\u0142a prawid\u0142owa, natomiast\u00a0u pozosta\u0142ych czterech pacjentek pocz\u0105tkowo podejrzewano nowotw\u00f3r lub zmiany o charakterze zapalnym.<br \/>U trzech pacjentek zdiagnozowano brzuszn\u0105 posta\u0107 promienicy, u jednej twarzowo-szyjn\u0105, natomiast\u00a0u ostatniego zosta\u0142y zdiagnozowane r\u00f3wnolegle wyst\u0119puj\u0105ce postacie: brzuszna i twarzowo-szyjna. Jedynie\u00a0badanie histopatologiczne, kt\u00f3re mo\u017ce by\u0107 przeprowadzone dzi\u0119ki pobraniu materia\u0142u metodami inwazyjnymi,\u00a0pozwala na jednoznaczne ustalenie diagnozy. R\u00f3\u017cnicowanie wymaga wykonania dodatkowych bada\u0144, co\u00a0op\u00f3\u017ania wprowadzenie odpowiedniego leczenia. Liczba bia\u0142ych krwinek we krwi oraz CRP by\u0142y prawid\u0142owe\u00a0u badanych pacjentek. Cztery pacjentki zako\u0144czy\u0142y leczenie z sukcesem po 60-192 dniach, jedna nadal jest leczona.<br \/>Podsumowuj\u0105c, do wsp\u00f3lnych cech prezentowanych w pracy przypadk\u00f3w nale\u017cy p\u0142e\u0107 \u017ce\u0144ska, lokalizacja\u00a0(jama brzuszna i narz\u0105dy w jamie brzusznej) oraz brak objaw\u00f3w charakterystycznych pozwalaj\u0105cych postawi\u0107\u00a0jednoznaczn\u0105 diagnoz\u0119. Antybiotykoterapia, g\u0142\u00f3wnie doksycyklin\u0105 i beta-laktamami, przynios\u0142a w wi\u0119kszo\u015bci\u00a0przypadk\u00f3w ca\u0142kowit\u0105 regresj\u0119 zmian chorobowych. Po wczesnym postawieniu prawid\u0142owej diagnozy pacjent\u00a0mo\u017ce unikn\u0105\u0107 inwazyjnych zabieg\u00f3w operacyjnych. Bior\u0105c pod uwag\u0119 przyk\u0142ady naszych pacjent\u00f3w, uwa\u017camy,\u00a0\u017ce promienica powinna by\u0107 rozwa\u017cana w diagnostyce r\u00f3\u017cnicowej wszystkich guz\u00f3w brzucha, zw\u0142aszcza\u00a0u kobiet.<\/p>\n<p><strong>Skr\u00f3ty:<\/strong> WBC \u2013 liczba bia\u0142ych krwinek, CRP \u2013 bia\u0142ko C-reaktywne, CT \u2013 tomografia komputerowa, i.v. -\u00a0do\u017cylnie.<\/p><\/jats:p>","DOI":"10.32394\/pe.74.55","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T13:24:34Z","timestamp":1619184274000},"page":"644-651","source":"Crossref","is-referenced-by-count":0,"title":["Actinomycosis \u2013 a forgotten chronic infectious disease \u2013 case report series"],"prefix":"10.32394","volume":"74","author":[{"given":"P","family":"\u0141anowy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bichalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"\u015alusarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Pyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dzindzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"B\u0142aszkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Oczko-Grzesik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jaroszewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2021,4,8]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Promienica \u2013 zapomniana, przewlek\u0142a choroba zaka\u017ana \u2013 seria opis\u00f3w przypadk\u00f3w"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180969-101532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180969-101532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:45:23Z","timestamp":1709887523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Actinomycosis-a-forgotten-chronic-infectious-disease-case-report-series,180969,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"alternative-id":["180969"],"URL":"https:\/\/doi.org\/10.32394\/pe.74.55","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]}}}