{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T09:11:41Z","timestamp":1709889101074},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/>We describe the case of a HIV-infected patient, in whom a secondary syphilis with skin lesions and ocular\u00a0involvement developed.<br \/>On admission papular skin rash and partial visual loss with left eye were observed. Serological tests for syphilis\u00a0were positive in very high titers. Ophthalmological examination revealed ocular abnormalities indicating ocular\u00a0syphilis. Cerebrospinal fluid (CSF) tests showed elevated concentration of immunoglobulin G (IgG) with normal\u00a0white blood count and albumin concentration, serological treponemal tests for syphilis were positive.\u00a0<br \/>Intravenous therapy with Penicillinum Crystallisatum (Benzylpenicillinum kalicum) was administered,\u00a0according to the neurosyphilis treatment schedule, achieving resolution of the skin lesions and partial vision\u00a0improvement, a month after the end of the treatment a complete recovery of the vision was noted. Serological\u00a0tests` for syphilis titers decreased fourfold.<br \/>Described case confirms reasonability of examination for syphilis in patients with sudden vision disturbances,\u00a0especially those HIV-infected. It also indicates that early appropriate treatment of the ocular syphilis prevents\u00a0permanent loss of vision.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/>Prezentujemy przypadek chorego zaka\u017conego HIV, u kt\u00f3rego wyst\u0105pi\u0142a ki\u0142a wczesna nawrotowa z objawami\u00a0sk\u00f3rnymi i zaj\u0119ciem narz\u0105du wzroku.<br \/>Przy przyj\u0119ciu stwierdzono osutk\u0119 grudkow\u0105 i cz\u0119\u015bciow\u0105 utrat\u0119 widzenia lewym okiem. Ki\u0142owe odczyny serologiczne\u00a0by\u0142y dodatnie o bardzo wysokich mianach. Badanie okulistyczne wykaza\u0142o odchylenia mog\u0105ce odpowiada\u0107\u00a0kile narz\u0105du wzroku. W p\u0142ynie m\u00f3zgowo-rdzeniowym (PMR) stwierdzono podwy\u017cszone st\u0119\u017cenie\u00a0immunoglobuliny G (IgG) przy prawid\u0142owej cytozie i st\u0119\u017ceniu albumin oraz dodatnie ki\u0142owe odczyny kr\u0119tkowe.<br \/>Wdro\u017cono leczenie penicylin\u0105 krystaliczn\u0105 do\u017cylnie, wed\u0142ug schematu leczenia ki\u0142y o\u015brodkowego uk\u0142adu\u00a0nerwowego (OUN). Uzyskano ust\u0105pienie zmian sk\u00f3rnych i cz\u0119\u015bciow\u0105 popraw\u0119 widzenia, po miesi\u0105cu od zako\u0144czenia\u00a0leczenia ca\u0142kowity powr\u00f3t widzenia. Miana ki\u0142owych odczyn\u00f3w serologicznych uleg\u0142y czterokrotnemu\u00a0obni\u017ceniu.<br \/>Opisywany przypadek potwierdza zasadno\u015b\u0107 diagnostyki w kierunku ki\u0142y u os\u00f3b z nag\u0142ymi zaburzeniami\u00a0widzenia, zw\u0142aszcza u pacjent\u00f3w zaka\u017conych HIV. Wskazuje r\u00f3wnie\u017c, \u017ce odpowiednio szybkie podj\u0119cie adekwatnego\u00a0leczenia pomaga zapobiec trwa\u0142ej utracie wzroku.<\/p><\/jats:p>","DOI":"10.32394\/pe.75.16","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T13:42:41Z","timestamp":1635169361000},"page":"175-183","source":"Crossref","is-referenced-by-count":0,"title":["Secondary syphilis with ocular involvement in a HIV-infected patient \u2013 case report"],"prefix":"10.32394","volume":"75","author":[{"given":"AM","family":"Olszewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Reduta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bacharewicz-Szczerbicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Flisiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2021,10,15]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Ki\u0142a drugiego okresu z zaj\u0119ciem narz\u0105du wzroku u pacjenta zaka\u017conego HIV \u2013 opis przypadku"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180998-101559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-180998-101559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:44:55Z","timestamp":1709887495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Secondary-syphilis-with-ocular-involvement-in-a-HIV-infected-patient-case-report,180998,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["180998"],"URL":"https:\/\/doi.org\/10.32394\/pe.75.16","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}