{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T05:55:39Z","timestamp":1716875739469},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>INTRODUCTION.<\/strong> In Poland, the number of reported cases of tick-borne encephalitis, and thus the designation\u00a0of the regions of TBE occurrence, seems to be underestimated.<br \/><strong>AIM OF THE STUDY.<\/strong> The aim of the study was to evaluate the impact of the implementation of TBE virus\u00a0infection tests in the routine diagnostics of patients with neuroinfections of undetermined viral etiology on the\u00a0identification of TBE virus infections in areas considered non-endemic and finding new areas of TBE occurrence.<br \/><strong>MATERIAL AND METHODS.<\/strong> Twenty-nine departments in which patients with suspected neuroinfections\u00a0are hospitalized participated in the study. The criterion for selecting the center was the location in an area\u00a0considered non-endemic for TBE, where reporting is low or absent, and intermediate data indicate the\u00a0possibility of undiagnosed disease (TBE). Diagnostics were performed in the Immunoserology Laboratory at the\u00a0Department of Infectious Diseases and Neuroinfections of the Medical University of Bialystok using the ELISA\u00a0method. The cooperation was undertaken with infectious wards or patients with suspected neuroinfection who\u00a0are hospitalized and diagnosed (e.g., neurology ward). The supervising unit is the Department of Infectious\u00a0Diseases and Neuroinfections of the Medical University of Bialystok, ul. \u017burawia 14, 15-540 Bia\u0142ystok. For\u00a0testing the submitted serum and CSF samples by ELISA method were used commercial kits from Virotech\u00a0(Germany).<br \/><strong>RESULTS.<\/strong> A total of 577 samples from 417 patients were tested, including 290 serum samples and 287 CSF\u00a0samples. Serum antibodies against TBE were detected: IgM class in 27 samples, IgG class in 22 samples; in\u00a0CSF: IgM class in 39 samples, IgG in 21 samples. The etiology of TBE was confirmed in 55 cases, i.e. in 13.19%\u00a0of all tested people.<br \/><strong>CONCLUSIONS.<\/strong> 1. Detection of the presence of antibodies against TBE in samples of patients with\u00a0meningitis reported as other neuroinfections indicates the etiology of TBE. 2. The number of TBE cases may be\u00a0undiagnosed, and thus underestimated due to the failure to perform serological tests for TBE in areas considered\u00a0non-endemic. 3. The diagnosis and reporting of neuroinfections caused by the TBE virus is essential for a proper\u00a0risk assessment and in promoting prophylaxis in the form of vaccinations. 4. Preliminary results of the research\u00a0indicate the need for their continuation in all voivodeships.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>WST\u0118P.<\/strong> W Polsce liczba raportowanych przypadk\u00f3w kleszczowego zapalenia m\u00f3zgu, a tym samym oznaczenie\u00a0region\u00f3w wyst\u0119powania KZM, wydaj\u0105 si\u0119 by\u0107 niedoszacowane.<br \/><strong>CEL.<\/strong> Celem badania by\u0142a ocena wp\u0142ywu wdro\u017cenia bada\u0144 w kierunku zaka\u017cenia wirusem KZM do rutynowej\u00a0diagnostyki chorych z neuroinfekcj\u0105 o nieustalonej etiologii wirusowej, na identyfikacj\u0119 zaka\u017ce\u0144 wywo\u0142anych\u00a0wirusem KZM w obszarach uwa\u017canych za nieendemiczne oraz znalezienie nowych obszar\u00f3w wyst\u0119powania\u00a0KZM.<br \/><strong>MATERIA\u0141 I METODY.<\/strong> Do udzia\u0142u w badaniu przyst\u0105pi\u0142o 29 oddzia\u0142\u00f3w szpitalnych, w kt\u00f3rych hospitalizowani\u00a0s\u0105 chorzy z podejrzeniem neuroinfekcji. Kryterium doboru o\u015brodka by\u0142o po\u0142o\u017cenie na terenie uwa\u017canym\u00a0za nieendemiczny dla KZM, w kt\u00f3rym zg\u0142aszalno\u015b\u0107 jest niska lub jej brak, a dane po\u015brednie wskazuj\u0105 na mo\u017cliwo\u015b\u0107\u00a0wyst\u0119powania niezdiagnozowanej choroby (KZM). Wsp\u00f3\u0142prac\u0119 podj\u0119to z oddzia\u0142ami zaka\u017anymi lub\u00a0takimi w kt\u00f3rych hospitalizowani i diagnozowani s\u0105 pacjenci z podejrzeniem neuroinfekcji (np. oddzia\u0142 neurologiczny).\u00a0Jednostk\u0105 nadzoruj\u0105c\u0105 by\u0142a Klinika Chor\u00f3b Zaka\u017anych i Neuroinfekcji Uniwersytetu Medycznego\u00a0w Bia\u0142ymstoku, ul. \u017burawia 14, 15-540 Bia\u0142ystok. Diagnostyka wykonywana by\u0142a w Laboratorium Immunoserologicznym\u00a0przy Klinice Chor\u00f3b Zaka\u017anych i Neuroinfekcji UMB metod\u0105 ELISA. Do badania nades\u0142anych\u00a0pr\u00f3bek surowicy i PMR metod\u0105 ELISA u\u017cyto komercyjnych zestaw\u00f3w firmy Virotech (Niemcy).<br \/><strong>WYNIKI.<\/strong> Og\u00f3\u0142em przebadano 577 pr\u00f3bek pochodz\u0105cych od 417 pacjent\u00f3w, w tym 290 pr\u00f3bek surowicy oraz\u00a0287 pr\u00f3bek PMR. Przeciwcia\u0142a przeciw KZM w surowicy wykryto: w klasie IgM \u2013 w 27 pr\u00f3bkach, w klasie\u00a0IgG \u2013 w 21 pr\u00f3bkach; w PMR: w klasie IgM \u2013 w 39 pr\u00f3bkach, w klasie IgG w \u2013 w 21 pr\u00f3bkach. Etiologi\u0119 KZM\u00a0potwierdzono w 55 przypadkach, tj. u 13,19% wszystkich przebadanych os\u00f3b.<br \/><strong>WNIOSKI.<\/strong> 1. Wykrycie obecno\u015bci przeciwcia\u0142 przeciw KZM, w pr\u00f3bkach pochodz\u0105cych od chorych z zapaleniem\u00a0opon zg\u0142oszonych jako inne neuroinfekcje, wskazuje na etiologi\u0119 KZM. 2. Znacz\u0105ca liczba przypadk\u00f3w\u00a0KZM mo\u017ce by\u0107 nierozpoznana, a tym samym niedoszacowana z powodu niewykonywania bada\u0144 serologicznych\u00a0w kierunku KZM na terenach uwa\u017canych za nieendemiczne. 3. Rozpoznawanie i raportowanie neuroinfekcji\u00a0wywo\u0142anych przez wirusa KZM jest niezwykle istotne dla w\u0142a\u015bciwego wyznaczenia teren\u00f3w endemicznych.\u00a04. Wst\u0119pne wyniki bada\u0144 wskazuj\u0105 na potrzeb\u0119 ich kontynuacji na terenie wszystkich wojew\u00f3dztw.<\/p><\/jats:p>","DOI":"10.32394\/pe.75.48","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T11:35:49Z","timestamp":1652268949000},"page":"515-523","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the potential effect of the implementation of serological testing tick-borne encephalitis on the detection of this disease on areas considered as non-endemic in Poland \u2013 preliminary report"],"prefix":"10.32394","volume":"75","author":[{"given":"Joanna","family":"Zajkowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Waluk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Dunaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"\u015awierzbi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyna","family":"Hordowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Zajkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Paradowska-Stankiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2022,5,10]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":["Ocena potencjalnego wp\u0142ywu wdro\u017cenia bada\u0144 serologicznych w kierunku kleszczowego zapalenia m\u00f3zgu na wykrywalno\u015b\u0107 tej choroby na obszarach uwa\u017canych za nieendemiczne w Polsce \u2013 doniesienie wst\u0119pne"],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-181032-101593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-181032-101593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:52:31Z","timestamp":1709887951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Assessment-of-the-potential-effect-of-the-implementation-of-serological-testing-tick,181032,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"alternative-id":["181032"],"URL":"https:\/\/doi.org\/10.32394\/pe.75.48","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]}}}