{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:34:39Z","timestamp":1780554879265,"version":"3.54.1"},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Przegl Epidemiol"],"abstract":"<jats:p>&lt;p&gt;&lt;strong&gt;ABSTRACT&lt;\/strong&gt;&lt;br \/&gt;&lt;strong&gt;BACKGROUND&lt;\/strong&gt;. Chronic kidney disease (CKD) is a progressive and irreversible disease that leads to end-stage\u00a0renal disease. Many factors such as increased oxidative stress play a role in the occurrence of this complication.&lt;br \/&gt;Due to the effective role of the antioxidant defense system in controlling many of the complications in which\u00a0oxidative stress is involved, the present study was conducted to evaluate the role of antioxidants in the prevention\u00a0and treatment of chronic kidney disease.&lt;br \/&gt;&lt;strong&gt;METHODS&lt;\/strong&gt;. In this review study, studies using standard keywords in internal and external databases including:\u00a0SID, Magiran, IranDoc, Medlib, Science Direct, PubMed, Scopus, Embase, Web of Science, Medline and\u00a0Google Scholar search engine, were retrieved and selected without time limit.&lt;br \/&gt;&lt;strong&gt;RESULTS&lt;\/strong&gt;. Among the selected articles, 14 articles were eligible for inclusion in the study, which was performed\u00a0on more than 20,000 people and several animal models of rats from 2005 onwards. The results showed that there\u00a0is an inverse relationship between the concentration of antioxidant enzymes in the body and the intensity and\u00a0progression of CKD. In severe cases, a significant decrease in the concentration of antioxidant enzymes in the\u00a0body, as well as cofactors such as selenium, iron and zinc in the progressive and severe course of CKD has been\u00a0observed.&lt;br \/&gt;&lt;strong&gt;CONCLUSIONS&lt;\/strong&gt;. The positive and significant effect of antioxidant compounds in chronic kidney disease is\u00a0evident. The use of these compounds in the diet in the form of fruits, vegetables and grains, as well as the\u00a0supply of iron and zinc and other minerals elements as cofactors for the action of enzymatic antioxidants has an\u00a0effective role in the prevention and treatment of diseases by controlling free radicals.&lt;\/p&gt;<\/jats:p>","DOI":"10.32394\/pe.76.06","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T13:23:24Z","timestamp":1657632204000},"page":"51-57","source":"Crossref","is-referenced-by-count":5,"title":["Antioxidants and their role in the prevention and treatment of chronic kidney disease (CKD), perspective of complementary nursing and medicine: a review"],"prefix":"10.32394","volume":"76","author":[{"given":"Ali Hasanpour","family":"Dehkordi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Ghaderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Mardani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alizamen Salehifard","family":"Joneghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayda Hasanpour","family":"Dehkordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17323","published-online":{"date-parts":[[2022,6,13]]},"container-title":["Przeglad Epidemiologiczny"],"original-title":[],"link":[{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-181058-101619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/pdf-181058-101619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:44:06Z","timestamp":1709887446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.przeglepidemiol.pzh.gov.pl\/Antioxidants-and-their-role-in-the-prevention-and-treatment-of-chronic-kidney-disease,181058,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,13]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["181058"],"URL":"https:\/\/doi.org\/10.32394\/pe.76.06","relation":{},"ISSN":["0033-2100","2545-1898"],"issn-type":[{"value":"0033-2100","type":"print"},{"value":"2545-1898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,13]]}}}