{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:22:02Z","timestamp":1780334522059,"version":"3.54.1"},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rocz Panstw Zakl Hig"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>Background<\/strong>. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus\u00a0is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract.<br \/><strong>Objective<\/strong>. The aim of the study was to investigate the relationship between diet and health of the study participants and the\u00a0presence of gastrointestinal Candida spp. Susceptibility of Candida to antifungal drugs was determined.<br \/><strong>Material and methods<\/strong>. Material comprised of oral swabs and fecal samples self-collected by the study participants. The\u00a0participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men.\u00a0The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad\u2019s FUNGITEST\u2122 Kit designed for the susceptibility testing of yeasts to six antifungal drugs.<br \/><strong>Results<\/strong>. In the group with negative Candida spp. cultures, healthier wheat flour substitutes were consumed significantly\u00a0more frequently than in the group with positive Candida spp. cultures. Yellow cheeses and quark were eaten significantly\u00a0more frequently in the group with negative Candida spp. cultures. No antifungal resistance was detected in the study group.<br \/><strong>Conclusions<\/strong>. The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal\u00a0Candida spp. A higher consumption of cheese was observed in the group with negative Candida spp. cultures, which may\u00a0indicate the inhibitory effect of saturated fatty acids on the growth of human Candida spp. Sensitivity of C. albicans to\u00a0antifungal drugs may increase effectiveness of candidiasis treatment.<br \/><br \/><strong>STRESZCZENIE<\/strong><br \/><strong>Wprowadzenie<\/strong>. Candida spp. to najcz\u0119stszy element mikroflory przewodu pokarmowego. Ten grzyb dro\u017cd\u017copodobny jest oportunist\u0105,\u00a0ze wzgl\u0119du na mo\u017cliwo\u015b\u0107 powodowania chor\u00f3b we wszystkich odcinkach przewodu pokarmowego. Pomimo, \u017ce Candida\u00a0spp. jest jedn\u0105 z g\u0142\u00f3wnych przyczyn zaka\u017ce\u0144 oportunistycznych, to istnieje ograniczona liczba \u015brodk\u00f3w przeciwgrzybiczych\u00a0stosowanych w terapii. Szerokie zastosowanie antybiotyk\u00f3w spowodowa\u0142o zwi\u0119kszenie oporno\u015bci szczep\u00f3w na stosowane leki.<br \/><strong>Cel<\/strong>. Celem pracy by\u0142o zbadanie zale\u017cno\u015bci mi\u0119dzy diet\u0105 i stanem zdrowia os\u00f3b bior\u0105cych udzia\u0142 w badaniu, a obecno\u015bci\u0105\u00a0Candida spp. w przewodzie pokarmowym. Ponadto oceniono wra\u017cliwo\u015b\u0107 wyizolowanych szczep\u00f3w Candida spp. na najcz\u0119\u015bciej\u00a0stosowane leki przeciwgrzybicze.<br \/><strong>Materia\u0142 i metody<\/strong>. Materia\u0142em do badania by\u0142y wymazy z jamy ustnej i pr\u00f3bki ka\u0142u, pobrane samodzielnie przez badanych.\u00a0Badani wype\u0142niali ankiet\u0119 dotycz\u0105c\u0105 cz\u0119stotliwo\u015bci spo\u017cycia r\u00f3\u017cnych grup produkt\u00f3w spo\u017cywczych oraz wyst\u0119powania czynnik\u00f3w ryzyka kandydozy. Przebadano 30 os\u00f3b, w tym 28 kobiet i 2 m\u0119\u017cczyzn. Badanie przeprowadzono na terenie\u00a0miasta Wroc\u0142aw, w Polsce. Oznaczono wra\u017cliwo\u015bci uzyskanych Candida na leki przeciwgrzybicze z u\u017cyciem zestawu\u00a0FUNGITEST firmy Biorad, kt\u00f3ry umo\u017cliwia badanie wzrostu dro\u017cd\u017cak\u00f3w w obecno\u015bci 6 preparat\u00f3w przeciwgrzybiczych.<br \/><strong>Wyniki<\/strong>. Wykazano dodatni\u0105 korelacj\u0119 pomi\u0119dzy spo\u017cyciem produkt\u00f3w z oczyszczonej m\u0105ki pszennej, a wyst\u0119powaniem\u00a0Candida spp. w przewodzie pokarmowym. Zaobserwowano wy\u017csze spo\u017cycie ser\u00f3w w grupie os\u00f3b z wynikiem ujemnym\u00a0badania w kierunku Candida spp., co mo\u017ce wskazywa\u0107 hamuj\u0105cy wp\u0142yw nasyconych kwas\u00f3w t\u0142uszczowych na wzrost\u00a0Candida spp. w organizmie. W\u015br\u00f3d badanych szczep\u00f3w nie wykryto opornych na leki przeciwgrzybicze.<br \/><strong>Wnioski<\/strong>. Du\u017ce spo\u017cycie produkt\u00f3w z pszennej, oczyszczonej m\u0105ki by\u0142o zwi\u0105zane z obecno\u015bci\u0105 Candida spp. w przewodzie\u00a0pokarmowym badanych. Konsumpcja produkt\u00f3w bogatych w nasycone kwasy t\u0142uszczowe korelowa\u0142a ze zmniejszon\u0105\u00a0liczebno\u015bci\u0105 dro\u017cd\u017cak\u00f3w w przewodzie pokarmowym. Candida albicans wykazywa\u0142 wra\u017cliwo\u015b\u0107 na wszystkie leki zastosowanie\u00a0w te\u015bcie, co mo\u017ce zwi\u0119ksza\u0107 skuteczno\u015b\u0107 terapii kandydozy.<\/p><\/jats:p>","DOI":"10.32394\/rpzh.2019.0070","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T05:49:11Z","timestamp":1560923351000},"page":"195-200","source":"Crossref","is-referenced-by-count":17,"title":["The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs"],"prefix":"10.32394","volume":"70","author":[{"given":"Ma\u0142gorzata","family":"Jeziorek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Frej-M\u0105drzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Choroszy-Kr\u00f3l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17323","published-online":{"date-parts":[[2019,6,30]]},"container-title":["Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"],"original-title":[],"link":[{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182567-103063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182567-103063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:13:40Z","timestamp":1768475620000},"score":1,"resource":{"primary":{"URL":"https:\/\/roczniki.pzh.gov.pl\/The-influence-of-diet-on-gastrointestinal-Candida-spp-colonization-and-the-susceptibility,182567,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"alternative-id":["182567"],"URL":"https:\/\/doi.org\/10.32394\/rpzh.2019.0070","relation":{},"ISSN":["0035-7715","2451-2311"],"issn-type":[{"value":"0035-7715","type":"print"},{"value":"2451-2311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,30]]}}}