{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:34:29Z","timestamp":1768534469500,"version":"3.49.0"},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rocz Panstw Zakl Hig"],"abstract":"<p><strong>ABSTRACT<\/strong><br \/><strong>Background.<\/strong> SARS-CoV-2 virus is one of the largest RNA viruses, included in the coronavirus group, showing tropism\u00a0to airway epithelial cells. SARS-CoV-2 causes an acute respiratory infectious disease, Covid-19. According to WHO\u00a0reports, mortality due to Covid-19 is higher in the elderly and in those burdened with comorbidities such as diabetes,\u00a0obstructive pulmonary disease, coronary artery disease, cancer, hypertension, hepatitis B, obesity or chronic kidney\u00a0disease.<br \/><strong>Objective.<\/strong> The aim of the study was to review the current literature on the influence and importance of vitamin D levels\u00a0on the course of SARS-CoV-2 infection.<br \/><strong>Material and method.<\/strong> A systematic review of studies published from January 1, 2009 to June 31, 2021 has been\u00a0performed. For this purpose, bibliographic databases such as PubMed and Scopus were searched. The following keywords\u00a0and combinations were used: Covid-19, vitamin D, 25-hydroxy-vitamin D, vitamin D supplementation, SARS-CoV-2.<br \/><strong>Results.<\/strong> It has been shown that vitamin D plays an important role in the mechanisms of the innate immunity in the course\u00a0of the acute respiratory infections. The overlapping factors of the severity of COVID-19 disease, vitamin D deficiency, and\u00a0the prevalence of obesity, age scare, ethnicity, has led some researchers to hypothesize that vitamin D supplementation\u00a0may be promising as a preventive or therapeutic measure for COVID-19.<br \/><strong>Conclusions.<\/strong> A very important factor that has an immunomodulatory character is vitamin D, the adequate supplementation\u00a0of which can be a preventive or therapeutic measure in case of SARS-CoV-2 infection, especially in elderly people, with\u00a0obesity and other chronic diseases.<\/p>\n<p><strong>STRESZCZENIE<\/strong><br \/><strong>Wst\u0119p.<\/strong> Wirus SARS-CoV-2 to jeden z najwi\u0119kszych wirus\u00f3w RNA, zaliczany do grupy koronawirus\u00f3w, wykazuj\u0105cy\u00a0tropizm do kom\u00f3rek nab\u0142onka dr\u00f3g oddechowych. SARS-CoV-2 powoduje ostr\u0105 chorob\u0119 zaka\u017an\u0105 uk\u0142adu oddechowego,\u00a0Covid-19. Wed\u0142ug doniesie\u0144 WHO \u015bmiertelno\u015b\u0107 z powodu Covid-19 jest wy\u017csza u os\u00f3b starszych i obci\u0105\u017conych chorobami\u00a0wsp\u00f3\u0142istniej\u0105cymi, takimi jak cukrzyca, obturacyjna choroba p\u0142uc, choroba wie\u0144cowa, nowotwory, nadci\u015bnienie,\u00a0zapalenie w\u0105troby typu B, oty\u0142o\u015b\u0107 czy przewlek\u0142a choroba nerek.<br \/><strong>Cel.<\/strong> Celem pracy by\u0142 przegl\u0105d aktualnej literatury dotycz\u0105cej wp\u0142ywu i znaczenia poziomu witaminy D na przebieg\u00a0zaka\u017cenia SARS-CoV-2\u00a0<br \/><strong>Materia\u0142 i metody.<\/strong> Przeprowadzono systematyczny przegl\u0105d bada\u0144 opublikowanych od 1 stycznia 2009 r. do 31 czerwca\u00a02021 r. W tym celu przeszukano bazy bibliograficzne, takie jak baza PubMed i baza Scopus firmy Elsevier. Zastosowano\u00a0nast\u0119puj\u0105ce s\u0142owa kluczowe i kombinacje: Covid-19, witamina D, 25-hydroksy-witamina D, suplementacja witamin\u0105 D,\u00a0SARS-CoV-2.<br \/><strong>Wyniki.<\/strong> Wykazano, \u017ce witamina D odgrywa wa\u017cn\u0105 rol\u0119 w mechanizmach odporno\u015bci wrodzonej w przebiegu ostrych\u00a0infekcji dr\u00f3g oddechowych. Nak\u0142adanie si\u0119 czynnik\u00f3w ci\u0119\u017ckiego przebiegu choroby COVID-19, niedoboru witaminy\u00a0D oraz wyst\u0119powania oty\u0142o\u015bci, straszy wiek, pochodzenie etniczne, doprowadzi\u0142 niekt\u00f3rych badaczy do hipotezy, \u017ce\u00a0suplementacja witaminy D mo\u017ce by\u0107 obiecuj\u0105ca jako \u015brodek zapobiegawczy lub terapeutyczny w przypadku COVID-19.<br \/><strong>Wnioski.<\/strong> Bardzo wa\u017cnym czynnikiem o charakterze immunomoduluj\u0105cym jest witamina D, kt\u00f3rej odpowiednia\u00a0suplementacja mo\u017ce by\u0107 \u015brodkiem zapobiegawczym lub terapeutycznym w przypadku zaka\u017cenia SARS-CoV-2, zw\u0142aszcza\u00a0u os\u00f3b starszych, z oty\u0142o\u015bci\u0105 i innymi chorobami przewlek\u0142ymi.<\/p><\/jats:p>","DOI":"10.32394\/rpzh.2022.0191","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T10:52:41Z","timestamp":1648205561000},"page":"5-12","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D in SARS-CoV-2 infection"],"prefix":"10.32394","volume":"73","author":[{"given":"Agnieszka","family":"Decyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Kobyli\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Antosik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kurowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2022,3,31]]},"container-title":["Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"],"original-title":[],"link":[{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182696-103192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182696-103192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:01:26Z","timestamp":1768474886000},"score":1,"resource":{"primary":{"URL":"https:\/\/roczniki.pzh.gov.pl\/Vitamin-D-in-SARS-CoV-2-infection,182696,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["182696"],"URL":"https:\/\/doi.org\/10.32394\/rpzh.2022.0191","relation":{},"ISSN":["0035-7715","2451-2311"],"issn-type":[{"value":"0035-7715","type":"print"},{"value":"2451-2311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]}}}