{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:07:31Z","timestamp":1768532851907,"version":"3.49.0"},"reference-count":0,"publisher":"National Institute of Public Health NIH (National Research Institute)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rocz Panstw Zakl Hig"],"abstract":"<jats:p>&lt;p&gt;&lt;strong&gt;ABSTRACT&lt;\/strong&gt;&lt;br \/&gt;&lt;strong&gt;Background.&lt;\/strong&gt; Every year the number of cases of colorectal cancer increases. Chemotherapy is one of the main methods of\u00a0treating cancer. However, chemotherapeutic treatment of colorectal cancer is inextricably linked to hepatotoxic reactions.&lt;br \/&gt;&lt;strong&gt;Objective.&lt;\/strong&gt; The aim of this study was to investigate the effect of the cytostatic vincristine on the background of previous\u00a0enterosorption correction with the drug aut-m in adenocarcinoma of the colon.&lt;br \/&gt;&lt;strong&gt;Material and methods.&lt;\/strong&gt; To simulate carcinogenesis, dimethylhydrazine (DMH) was administered subcutaneously to 77\u00a0rats for 30 weeks at a dose of 7.2 mg\/kg body weight. After simulation of colon cancer, the animals were intragastricly\u00a0administered entorosorbent at a dose of 1 ml of suspension (corresponding to 0.2 g of net weight of the drug) per 100\u00a0g of body weight of the animal, daily for 21 days. After detoxification therapy, rats with simulated carcinogenesis were\u00a0administered the daily cytostatic vincristine at a dose of 0.23 mg\/kg for 14 days.&lt;br \/&gt;&lt;strong&gt;Results.&lt;\/strong&gt; It was found that prolonged administration of dimethylhydrazine is accompanied by destructive changes in\u00a0plasma membranes, as evidenced by increased activity of enzymes alanine aminotransferase, aspartate aminotransferase,\u00a0alkaline phosphatase, and serum urea.&lt;br \/&gt;&lt;strong&gt;Conclusions.&lt;\/strong&gt; The used sorbent aut-m showed an effective effect on reducing the manifestations of cytolytic processes in\u00a0induced carcinogenesis, as indicated by the normalization of the studied parameters. The cytostatic vincristine, which\u00a0was used in rats with induced colorectal cancer after enterosorption therapy, did not significantly affect the enhancement\u00a0of cytolytic processes, which confirms the effectiveness of previous sorption measures under these conditions.&lt;\/p&gt;<\/jats:p>","DOI":"10.32394\/rpzh.2022.0212","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T08:52:38Z","timestamp":1656060758000},"page":"215-220","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of membrane-destructive processes in rats with induced carcinogenesis of the colon using the cytostatic vincristine"],"prefix":"10.32394","volume":"73","author":[{"given":"Oksana","family":"Kachur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liudmyla","family":"Fira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro","family":"Lykhatsky\u0456","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro","family":"Fira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Garlitska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17323","published-online":{"date-parts":[[2022,6,30]]},"container-title":["Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"],"original-title":[],"link":[{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182717-103213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/roczniki.pzh.gov.pl\/pdf-182717-103213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:00:51Z","timestamp":1768474851000},"score":1,"resource":{"primary":{"URL":"https:\/\/roczniki.pzh.gov.pl\/Evaluation-of-membrane-destructive-processes-in-rats-with-induced-carcinogenesis,182717,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["182717"],"URL":"https:\/\/doi.org\/10.32394\/rpzh.2022.0212","relation":{},"ISSN":["0035-7715","2451-2311"],"issn-type":[{"value":"0035-7715","type":"print"},{"value":"2451-2311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}