{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:33:12Z","timestamp":1713659592194},"reference-count":0,"publisher":"DoNotEdit","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ARI"],"published-print":{"date-parts":[[2023,8,30]]},"abstract":"<jats:p>Obesity and its associated disorders, such as hyperlipidemia, have become a \u200eglobal issue \u200efollowing the consumption of unhealthy, high-fat, and high-\u200ecarbohydrate foods, which \u200eburdens the economies and the \u200ehealth systems of human societies \u200eworldwide\u200e.\u200e\u200f\u200e\u200f \u200fThis study aimed to evaluate \u200ethe effect of oral consumption of 6-gingerol and L-arginine \u200esupplements on \u200eserum lipid profile (triglyceride, cholesterol, high-density lipoprotein, and \u200elow-density lipoprotein), obesity factors, insulin, corticosterone and testosterone hormones, \u200eand \u200eexpression of neuropeptide Y (NPY) gene in high-carbohydrate diet (HCD) \u200einduced \u200eobese rats. Thirty rats in five groups were fed a diet specific to each \u200egroup for 12 weeks \u200eand then treated with the oral administration of L-arginine \u200e\u200e(200 mg\/day) and 6-gingerol (100 \u200emg\/day) for twelve weeks. The food and water \u200eintake and weight change were then measured\u200e. In addition, plasma glucose, \u200etriglyceride, cholesterol, high-density lipoprotein \u200e\u200e(HDL), very-low-density lipoprotein (VLDL)\u200e, low-density \u200elipoprotein (LDL), and serum \u200ehormone levels, including corticosterone, testosterone, and insulin, were measured, and NPY, \u200eY1, and Y5 receptor gene expression were recorded using real-time PCR. Administration of \u200e\u200e6-gingerol and L-arginine decreased food intake, \u200eweight \u200egain\u200e, glucose levels, insulin levels, \u200eand homeostasis model assessment-insulin resistance (HOMA-IR) index compared to \u200ethe \u200eHCD control group. In addition, corticosterone and testosterone levels in the \u200estudy groups \u200eshowed a significant decrease (P<\/jats:p>","DOI":"10.32592\/ari.2024.79.1.180","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:23:11Z","timestamp":1713604991000},"page":"180-188","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of Neuropeptide Y Receptor Gene Expression and \u200eHormone Level in Obese Male Rats Receiving 6-Gingerol and L-Arginine \u200eSupplementation"],"prefix":"10.32592","member":"17542","published-online":{"date-parts":[[2024,4,20]]},"container-title":["Archives of Razi Institute"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:23:12Z","timestamp":1713604992000},"score":1,"resource":{"primary":{"URL":"https:\/\/archrazi.areeo.ac.ir\/article_129776.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.32592\/ari.2024.79.1.180","archive":["Internet Archive"],"relation":{},"ISSN":["2008-9872","0365-3439"],"issn-type":[{"value":"2008-9872","type":"electronic"},{"value":"0365-3439","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,30]]}}}