{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:54:20Z","timestamp":1780620860407,"version":"3.54.1"},"reference-count":0,"publisher":"Negah Scientific Publisher","issue":"02","content-domain":{"domain":["www.niscpub.com"],"crossmark-restriction":false},"short-container-title":["BCN"],"abstract":"<jats:p>Introduction: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures.  Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: \u201cDeep brain stimulation,\u201d \u201cParkinson disease,\u201d \u201cdementia,\u201d and \u201cmemory.\u201d Reviews, abstracts, case presentations, and letters were excluded.  Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia. Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings.<\/jats:p>","DOI":"10.32598\/bcn.2021.3420.1","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:11:00Z","timestamp":1635682260000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.32598\/nsp.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis"],"prefix":"10.32598","volume":"15","author":[{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Razmkon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Abdollahifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirad","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Reza","family":"Bahadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Eskandarzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AmirAli Rastegar","family":"Kazerooni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17540","published-online":{"date-parts":[[2024,3,1]]},"container-title":["Basic and Clinical Neuroscience Journal"],"original-title":[],"link":[{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2177-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2177-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:37:40Z","timestamp":1719988660000},"score":1,"resource":{"primary":{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2177-en.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.32598\/bcn.2021.3420.1","relation":{},"ISSN":["2008-126X","2228-7442"],"issn-type":[{"value":"2008-126X","type":"print"},{"value":"2228-7442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}