{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:10:04Z","timestamp":1779300604625,"version":"3.51.4"},"reference-count":0,"publisher":"Negah Scientific Publisher","issue":"02","content-domain":{"domain":["www.niscpub.com"],"crossmark-restriction":false},"short-container-title":["BCN"],"abstract":"<jats:p>Introduction: Parkinson disease is the world\u2019s second most prevalent neurological disease. In this disease, intracytoplasmic neuronal inclusions are observed in enteric neurons in the gastrointestinal tract, and the composition of the intestinal microbiome is altered. These changes correlate with the motor phenotype. A systematic review was conducted to determine the effect of using probiotics in Parkinson disease. Methods: Scopus, PubMed, Web of Science, the Cochrane Library, ScienceDirect, and Ov\u0131d-LWW were searched until April 2021. A total of 27395 records were found according to inclusion and exclusion criteria with the following outcomes: Parkinson disease rating, oxidative stress, and gastrointestinal system markers. Data search, article selection, and data extraction assessments were performed according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. The Jadad scale was used to rate the evidence\u2019s quality. Results: Our study information was gathered from 5 randomized controlled trials involving 350 individuals with Parkinson disease receiving probiotic supplements. Parkinson disease rating and non-motor symptoms test were performed in the samples. Also, oxidative stress (glutathione, malondialdehyde) and gastrointestinal system symptoms (bowel opening frequency, gut transit time, complete bowel movement, spontaneous bowel movements) were evaluated during 4-12 weeks of using probiotics in these patients.  Conclusion: While all high-quality studies demonstrate improvement in disease symptoms of the patients, currently sufficient data are not available to recommend the use of probiotics for people with Parkinson disease in clinical practice.<\/jats:p>","DOI":"10.32598\/bcn.2022.3665.1","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T08:32:55Z","timestamp":1638693175000},"page":"165-174","update-policy":"https:\/\/doi.org\/10.32598\/nsp.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic Targets of Probiotics in Parkinson Disease: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.32598","volume":"15","author":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Sina","family":"Atak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcmeysa Rabia","family":"Kocat\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Temizy\u00fcrek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Physiology, School of Medicine, Ko\u00e7 University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6znur \u00d6zge","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Molecular Neuroscience, Health Sciences Institute, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcrker Tekin","family":"Erg\u00fczel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Software Engineering, Faculty of Engineering and Natural Sciences, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Karahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, \u00dcsk\u00fcdar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevzat","family":"Tarhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Psychiatry, School of Medicine, \u00dcskudar University, Istanbul, Turkey.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17540","published-online":{"date-parts":[[2024,3,1]]},"container-title":["Basic and Clinical Neuroscience Journal"],"original-title":[],"link":[{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2262-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2262-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:37:41Z","timestamp":1719988661000},"score":1,"resource":{"primary":{"URL":"https:\/\/bcn.iums.ac.ir\/article-1-2262-en.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.32598\/bcn.2022.3665.1","relation":{},"ISSN":["2008-126X","2228-7442"],"issn-type":[{"value":"2008-126X","type":"print"},{"value":"2228-7442","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}