{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:55:42Z","timestamp":1792932942534,"version":"4.5.0"},"reference-count":38,"publisher":"Tech Science Press","issue":"4","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":874,"URL":"https:\/\/doi.org\/10.32604\/TSP-CROSSMARKPOLICY"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.32604\/chd.2020.012219","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T07:41:09Z","timestamp":1600933269000},"page":"251-265","update-policy":"https:\/\/doi.org\/10.32604\/tsp-crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants\nwith Congenital Heart Disease"],"prefix":"10.32604","volume":"15","author":[{"given":"Evan","family":"Pagano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Jaggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Twite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"T. Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17807","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jpba.2014.12.017","article-title":"Metabolomics for laboratory diagnostics","volume":"113","author":"Bujak","year":"2015","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1097\/CCM.0000000000000982","article-title":"Metabolic profiling of children undergoing surgery for congenital heart disease","volume":"43","author":"Correia","year":"2015","journal-title":"Critical Care Medicine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1161\/CIRCRESAHA.117.311002","article-title":"Cardiovascular metabolomics","volume":"122","author":"McGarrah","year":"2018","journal-title":"Circulation Research"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e010711","DOI":"10.1161\/JAHA.118.010711","article-title":"Metabolomic fingerprinting of infants undergoing cardiopulmonary bypass: changes in metabolic pathways and association with mortality and cardiac intensive care unit length of stay","volume":"7","author":"Davidson","year":"2018","journal-title":"Journal of the American Heart Association"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/SHK.0000000000000948","article-title":"The metabolopathy of tissue injury, hemorrhagic shock, and resuscitation in a rat model","volume":"49","author":"Slaughter","year":"2018","journal-title":"SHOCK"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e000032","DOI":"10.1161\/HCG.0000000000000032","article-title":"Potential impact and study considerations of metabolomics in cardiovascular health and disease: a scientific statement from the american heart association","volume":"10","author":"Cheng","year":"2017","journal-title":"Circulation Cardiovascular Genetics"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e99096","DOI":"10.1172\/jci.insight.99096","article-title":"Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk","volume":"3","author":"Li","year":"2018","journal-title":"Journal of Clinical Investigation Insight"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.114.013116","article-title":"Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts","volume":"131","author":"Wurtz","year":"2015","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e0158981","DOI":"10.1371\/journal.pone.0158981","article-title":"Alkaline phosphatase soluble extracellular adenine nucleotides, and adenosine production after infant cardiopulmonary bypass","volume":"11","author":"Davidson","year":"2016","journal-title":"PLoS ONE"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpeds.2017.07.035","article-title":"Alkaline phosphatase in infant cardiopulmonary bypass: kinetics and relationship to organ injury and major cardiovascular events","volume":"190","author":"Davidson","year":"2017","journal-title":"Journal of Pediatrics"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11306-019-1605-3","article-title":"Urinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair","volume":"15","author":"Simonato","year":"2019","journal-title":"Metabolomics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e0161123","DOI":"10.1371\/journal.pone.0161123","article-title":"The role of plasma and urine metabolomics in identifying new biomarkers in severe newborn asphyxia: a study of asphyxiated newborn pigs following cardiopulmonary resuscitation","volume":"11","author":"Sachse","year":"2016","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/501612","article-title":"The endothelial ADMA\/NO pathway in hypoxia-related chronic respiratory diseases","volume":"2014","author":"Luneburg","year":"2014","journal-title":"BioMed Research International"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e0214549","DOI":"10.1007\/s11306-020-01666-2","article-title":"The key points in the pre-analytical procedures of blood and urine samples in metabolomics studies","volume":"16","author":"Bi","year":"2020","journal-title":"Metabolomics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/metabo9080156","article-title":"Pre-analytical factors that affect metabolite stability in human urine, plasma, and serum: a review","volume":"9","author":"Stevens","year":"2019","journal-title":"Metabolites"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nature Protocols"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.clinbiochem.2016.06.002","article-title":"Amino acids in a targeted versus a non-targeted metabolomics LC-MS\/MS assay. Are the results consistent?","volume":"49","author":"Klepacki","year":"2016","journal-title":"Clinical Biochemistry"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.5665\/sleep.3038","article-title":"Long-term intermittent hypoxia elevates cobalt levels in the brain and injures white matter in adult mice","volume":"36","author":"Veasey","year":"2013","journal-title":"Sleep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1006\/bbrc.1998.9852","article-title":"Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase","volume":"253","author":"Kitazono","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.tcm.2017.10.003","article-title":"Thymidine phosphorylase: a potential new target for treating cardiovascular disease","volume":"28","author":"Li","year":"2018","journal-title":"Trends in Cardiovascular Medicine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Shweiki","year":"1992","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.1523\/JNEUROSCI.5030-06.2007","article-title":"Hypoxia suppresses glutamate transport in astrocytes","volume":"27","author":"Dallas","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/0165-6147(90)90129-V","article-title":"The release and uptake of excitatory amino acids","volume":"11","author":"Nicholls","year":"1990","journal-title":"Trends in Pharmacological Sciences"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12079-015-0315-5","article-title":"A pathway map of glutamate metabolism","volume":"10","author":"Yelamanchi","year":"2016","journal-title":"Journal of Cell Communication and Signaling"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1046\/j.1471-4159.2001.00214.x","article-title":"Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells","volume":"76","author":"Kobayashi","year":"2001","journal-title":"Journal of Neurochemistry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e77182","DOI":"10.1371\/journal.pone.0077182","article-title":"Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin","volume":"8","author":"Lourhmati","year":"2013","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1651-2227.2002.tb02904.x","article-title":"Erythropoietin in the central nervous system, and its use to prevent hypoxic-ischemic brain damage","volume":"91","author":"Juul","year":"2002","journal-title":"Acta Paediatrica Supplementum"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3324\/haematol.2017.178608","article-title":"Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage","volume":"103","author":"Nemkov","year":"2018","journal-title":"Haematologica"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1203\/00006450-198802000-00001","article-title":"Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production","volume":"23","author":"Saugstad","year":"1988","journal-title":"Pediatric Research"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jcp.36.1.1","article-title":"Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: high concentrations of the ATP metabolite, hypoxanthine, after hypoxia","volume":"36","author":"Harkness","year":"1983","journal-title":"Journal of Clinical Pathology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0379-0738(94)90296-8","article-title":"Hypoxanthine in vitreous humor and cerebrospinal fluid\u2013a marker of postmortem interval and prolonged (vital) hypoxia? Remarks also on hypoxanthine in SIDS","volume":"65","author":"Madea","year":"1994","journal-title":"Forensic Science International"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/15257771003741364","article-title":"Protection of mouse heart against hypoxic damage by AMP deaminase inhibition","volume":"29","author":"Borkowski","year":"2010","journal-title":"Nucleosides, Nucleotides and Nucleic Acids"},{"key":"ref35","first-page":"A19495","article-title":"Abstract 19495: cardioprotective effect of AMP deaminase inhibition in oxygen deprivation","volume":"122","author":"Smolenski","year":"2010","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/978-3-319-91137-3_20","article-title":"Myo-inositol effects on the developing respiratory neural control system","volume":"1071","author":"MacFarlane","year":"2018","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1098\/rstb.1988.0083","article-title":"Neural function: metabolism and actions of inositol metabolites in mammalian brain","volume":"320","author":"Hanley","year":"1997","journal-title":"Philosophical Transactions of the Royal Society of London Series B Biological Sciences"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1968450","article-title":"Inositols in insulin signaling and glucose metabolism","volume":"2018","author":"Bevilacqua","year":"2018","journal-title":"International Journal of Endocrinology"}],"container-title":["Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.techscience.com\/uploads\/attached\/file\/20210708\/20210708064715_68977.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T21:25:42Z","timestamp":1733520342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/chd\/v15n4\/40120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.32604\/chd.2020.012219","relation":{},"ISSN":["1747-079X"],"issn-type":[{"value":"1747-079X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"2020-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-07","order":2,"name":"published","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}