{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:40:49Z","timestamp":1784256049366,"version":"3.55.0"},"reference-count":131,"publisher":"Tech Science Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJU"],"published-print":{"date-parts":[[2025]]},"DOI":"10.32604\/cju.2025.066523","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:51:28Z","timestamp":1751601088000},"page":"255-269","source":"Crossref","is-referenced-by-count":1,"title":["Crosstalk between mitochondrial dysfunction and benign prostatic hyperplasia: unraveling the intrinsic mechanisms"],"prefix":"10.32604","volume":"32","author":[{"given":"Huan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17807","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1038\/nrdp.2016.31","article-title":"Benign prostatic hyperplasia","volume":"2","author":"Chughtai","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.purol.2018.08.005","article-title":"Epidemiology of benign prostatic hyperplasia","volume":"28","author":"Robert","year":"2018","journal-title":"Prog Urol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/bju.15286","article-title":"The rising worldwide impact of benign prostatic hyperplasia","volume":"127","author":"Launer","year":"2021","journal-title":"BJU Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2478875","DOI":"10.1080\/13685538.2025.2478875","article-title":"National prevalence and incidence of benign prostatic hyperplasia\/lower urinary tract symptoms and validated risk factors pattern","volume":"28","author":"Lin","year":"2025","journal-title":"Aging Male"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12894-025-01715-9","article-title":"Global, regional, and national burden of benign prostatic hyperplasia from 1990 to 2021 and projection to 2035","volume":"25","author":"Wei","year":"2025","journal-title":"BMC Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1016\/S2666-7568(22)00213-6","article-title":"The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: a systematic analysis for the global burden of disease study 2019","volume":"3","year":"2022","journal-title":"Lancet Healthy Longev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/pros.24114","article-title":"Inhibition of human prostate stromal cell growth and smooth muscle contraction by thalidomide: a novel remedy in LUTS?","volume":"81","author":"Tamalunas","year":"2021","journal-title":"Prostate"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/bju.15229","article-title":"Benign prostatic hyperplasia\u2014what do we know?","volume":"127","author":"Devlin","year":"2021","journal-title":"BJU Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1073\/pnas.0812666106","article-title":"A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia","volume":"106","author":"Alonso-Magdalena","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"103511","DOI":"10.1016\/j.autrev.2023.103511","article-title":"Benign prostatic hyperplasia\u2014A novel autoimmune disease with a potential therapy consequence?","volume":"23","author":"Liedtke","year":"2024","journal-title":"Autoimmun Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13046-016-0418-8","article-title":"Oxidative stress in prostate hyperplasia and carcinogenesis","volume":"35","author":"Udensi","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"101426","DOI":"10.1016\/j.redox.2020.101426","article-title":"Mitochondrial quality control in pulmonary fibrosis","volume":"33","author":"Larson-Casey","year":"2020","journal-title":"Redox Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mito.2019.10.003","article-title":"The basic machineries for mitochondrial protein quality control","volume":"50","author":"Vazquez-Calvo","year":"2020","journal-title":"Mitochondrion"},{"key":"ref14","first-page":"816","article-title":"Targeting mitophagy in neurodegenerative diseases","volume":"46","author":"Antico","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/CIRCRESAHA.116.307505","article-title":"Mitochondrial metabolism in aging heart","volume":"118","author":"Lesnefsky","year":"2016","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/abbs\/gmr007","article-title":"PGC-1 coactivators in the control of energy metabolism","volume":"43","author":"Liu","year":"2011","journal-title":"Acta Biochim Biophys Sin"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"216705","DOI":"10.1016\/j.canlet.2024.216705","article-title":"Cancer resistance and metastasis are maintained through oxidative phosphorylation","volume":"587","author":"Uslu","year":"2024","journal-title":"Cancer Lett"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1007\/s12035-019-1544-z","article-title":"Synergy in disruption of mitochondrial dynamics by A\u03b2 (1-42) and glia maturation factor (GMF) in SH-SY5Y cells is mediated through alterations in fission and fusion proteins","volume":"56","author":"Ahmed","year":"2019","journal-title":"Mol Neurobiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"102867","DOI":"10.1016\/j.autrev.2021.102867","article-title":"Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: potential role in Sj\u00f6gren\u2019s syndrome","volume":"20","author":"Barrera","year":"2021","journal-title":"Autoimmun Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"120980","DOI":"10.1016\/j.lfs.2022.120980","article-title":"Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor \u03b1","volume":"309","author":"Hong","year":"2022","journal-title":"Life Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1042\/CS20210476","article-title":"NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia","volume":"135","author":"Liu","year":"2021","journal-title":"Clin Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s12967-023-04432-9","article-title":"Glutathione peroxidase 3 induced mitochondria-mediated apoptosis via AMPK\/ERK1\/2 pathway and resisted autophagy-related ferroptosis via AMPK\/mTOR pathway in hyperplastic prostate","volume":"21","author":"Li","year":"2023","journal-title":"J Transl Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1056\/NEJM198307213090311","article-title":"Mitochondria\u2013structure, function, and replication","volume":"309","author":"Green","year":"1983","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"210238","DOI":"10.1098\/rsob.210238","article-title":"Pathways shaping the mitochondrial inner membrane","volume":"11","author":"Klecker","year":"2021","journal-title":"Open Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","article-title":"The assembly, regulation and function of the mitochondrial respiratory chain","volume":"23","author":"Vercellino","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The role of mitochondria in metabolism and cell death","volume":"482","author":"Vakifahmetoglu-Norberg","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s11307-020-01557-x","article-title":"The roles of ZnT1 and ZnT4 in glucose-stimulated zinc secretion in prostate epithelial cells","volume":"23","author":"Lo","year":"2021","journal-title":"Mol Imaging Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"101516","DOI":"10.1016\/j.molmet.2022.101516","article-title":"Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion","volume":"62","author":"Fr\u00e9geau-Proulx","year":"2022","journal-title":"Mol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/pros.2990150406","article-title":"Prostate epithelial cells utilize glucose and aspartate as the carbon sources for net citrate production","volume":"15","author":"Costello","year":"1989","journal-title":"Prostate"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12964-025-02081-7","article-title":"ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism","volume":"23","author":"L\u00f6f","year":"2025","journal-title":"Cell Commun Signal"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial proteins: from biogenesis to functional networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/jnr.24042","article-title":"Mitochondrial biogenesis in neurodegeneration","volume":"95","author":"Li","year":"2017","journal-title":"J Neurosci Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"101435","DOI":"10.1016\/j.redox.2020.101435","article-title":"Estrogenic control of mitochondrial function","volume":"31","author":"Klinge","year":"2020","journal-title":"Redox Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mito.2015.10.001","article-title":"Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: useful insights from aging and calorie restriction studies","volume":"25","author":"Picca","year":"2015","journal-title":"Mitochondrion"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e50629","DOI":"10.15252\/embr.202050629","article-title":"Mitophagy receptor FUNDC1 is regulated by PGC-1\u03b1\/NRF1 to fine tune mitochondrial homeostasis","volume":"22","author":"Liu","year":"2021","journal-title":"EMBO Rep"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"a015008","DOI":"10.1101\/cshperspect.a015008","article-title":"Mitochondrial biogenesis through activation of nuclear signaling proteins","volume":"5","author":"Dominy","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"103340","DOI":"10.1016\/j.redox.2024.103340","article-title":"Role of mitochondria in reno-cardiac diseases: a study of bioenergetics, biogenesis, and GSH signaling in disease transition","volume":"76","author":"Lumpuy-Castillo","year":"2024","journal-title":"Redox Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.3390\/biomedicines12102349","article-title":"Changes in TP53 gene, telomere length, and mitochondrial DNA in benign prostatic hyperplasia patients","volume":"12","author":"Zole","year":"2024","journal-title":"Biomedicines"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/pros.24208","article-title":"SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1\u03b1 axis in the development of benign prostatic hyperplasia","volume":"81","author":"Li","year":"2021","journal-title":"Prostate"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/biomedicines13020327","article-title":"Mitochondrial dysfunction in neurodegenerative diseases: mechanisms and corresponding therapeutic strategies","volume":"13","author":"Meng","year":"2025","journal-title":"Biomedicines"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature21077","article-title":"MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion","volume":"542","author":"Cao","year":"2017","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molcel.2004.09.026","volume":"16","author":"Szabadkai","year":"2004","journal-title":"Mol Cell"},{"key":"ref47","first-page":"599","article-title":"Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission","volume":"22","author":"Hong","year":"2024","journal-title":"Chin J Nat Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41419-022-04995-3","article-title":"Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3","volume":"13","author":"Park","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ceb.2011.05.007","article-title":"Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation","volume":"23","author":"Karbowski","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1097-2765(00)80242-7","article-title":"Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface","volume":"5","author":"Leonhard","year":"2000","journal-title":"Mol Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41586-024-07835-w","article-title":"Lysosomes drive the piecemeal removal of mitochondrial inner membrane","volume":"632","author":"Prashar","year":"2024","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cub.2011.11.057","article-title":"A vesicular transport pathway shuttles cargo from mitochondria to lysosomes","volume":"22","author":"Soubannier","year":"2012","journal-title":"Curr Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.cell.2021.04.027","article-title":"Mitocytosis, a migrasome-mediated mitochondrial quality-control process","volume":"184","author":"Jiao","year":"2021","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1038\/s41467-022-31213-7","article-title":"A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery","volume":"13","author":"Tan","year":"2022","journal-title":"Nat Commun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"42373","DOI":"10.1074\/jbc.M112.413674","article-title":"Electron microscopic analysis of a spherical mitochondrial structure","volume":"287","author":"Ding","year":"2012","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"113291","DOI":"10.1016\/j.celrep.2023.113291","article-title":"Mitochondria-lysosome-related organelles mediate mitochondrial clearance during cellular dedifferentiation","volume":"42","author":"Ma","year":"2023","journal-title":"Cell Rep"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1080\/15548627.2024.2408712","article-title":"Quality control of mitochondria involves lysosomes in multiple definitive ways","volume":"20","author":"Ma","year":"2024","journal-title":"Autophagy"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.3390\/foods12203836","article-title":"Kaempferol alleviates mitochondrial damage by reducing mitochondrial reactive oxygen species production in lipopolysaccharide-induced prostate organoids","volume":"12","author":"Lee","year":"2023","journal-title":"Foods"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0022-5347(01)61620-3","article-title":"The relative amount of epithelium, muscle, connective tissue and lumen in prostatic hyperplasia as a function of the mass of tissue resected","volume":"161","author":"Schuster","year":"1999","journal-title":"J Urol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41420-021-00501-4","article-title":"Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia","volume":"7","author":"Liu","year":"2021","journal-title":"Cell Death Discov"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/pros.24241","article-title":"Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP\/smad signaling pathway","volume":"81","author":"Liu","year":"2021","journal-title":"Prostate"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"123560","DOI":"10.1016\/j.lfs.2025.123560","article-title":"Testes-specific protease 50 heightens stem-like properties and improves mitochondrial function in colorectal cancer","volume":"370","author":"Gao","year":"2025","journal-title":"Life Sci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41419-025-07505-3","article-title":"TIMM23 overexpression drives NSCLC cell growth and survival by enhancing mitochondrial function","volume":"16","author":"Zha","year":"2025","journal-title":"Cell Death Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12964-025-02109-y","article-title":"SLC25A35 enhances fatty acid oxidation and mitochondrial biogenesis to promote the carcinogenesis and progression of hepatocellular carcinoma by upregulating PGC-1\u03b1","volume":"23","author":"Yu","year":"2025","journal-title":"Cell Commun Signal"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"115265","DOI":"10.1016\/j.celrep.2025.115265","article-title":"Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia","volume":"44","author":"Zhang","year":"2025","journal-title":"Cell Rep"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2477365","DOI":"10.1080\/15384047.2025.2477365","article-title":"PINCH-1 promotes tumor growth and metastasis by enhancing DRP1-mediated mitochondrial fission in head and neck squamous cell carcinoma","volume":"26","author":"Tian","year":"2025","journal-title":"Cancer Biol Ther"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13046-024-03194-6","article-title":"Targeting DNM1L\/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling","volume":"43","author":"Li","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.freeradbiomed.2025.01.047","article-title":"Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway","volume":"229","author":"Li","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.7150\/ijbs.107632","article-title":"DARS2 promotes bladder cancer progression by enhancing PINK1-mediated mitophagy","volume":"21","author":"Li","year":"2025","journal-title":"Int J Biol Sci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/pros.2990170506","article-title":"Medical management of benign prostatic hyperplasia with androgen suppression","volume":"3","author":"McConnell","year":"1990","journal-title":"Prostate Suppl"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"106551","DOI":"10.1016\/j.biocel.2024.106551","article-title":"S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate","volume":"169","author":"Yang","year":"2024","journal-title":"Int J Biochem Cell Biol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"110933","DOI":"10.1016\/j.cellsig.2023.110933","article-title":"STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia","volume":"113","author":"Liu","year":"2024","journal-title":"Cell Signal"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41419-022-05162-4","article-title":"METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e179570","DOI":"10.1172\/JCI179570","article-title":"Targeting apoptotic pathways for cancer therapy","volume":"134","author":"Tian","year":"2024","journal-title":"J Clin Invest"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41419-025-07504-4","article-title":"CKMT1 deficiency contributes to mitochondrial dysfunction and promotes intestinal epithelial cell apoptosis via reverse electron transfer-derived ROS in colitis","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2025.5738","volume":"66","author":"Liu","year":"2025","journal-title":"Int J Oncol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"167796","DOI":"10.1016\/j.bbadis.2025.167796","article-title":"HUWE1-mediated ubiquitination and degradation of oxidative damage repair gene ATM maintains mitochondrial quality control system in lens epithelial cells","volume":"1871","author":"Wang","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"102025","DOI":"10.1016\/j.mito.2025.102025","article-title":"Inhibition of the expression of TRIM63 alleviates ventilator-induced diaphragmatic dysfunction by modulating the PPAR\u03b1\/PGC-1\u03b1 pathway","volume":"83","author":"Liu","year":"2025","journal-title":"Mitochondrion"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.freeradbiomed.2025.03.022","article-title":"Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2\/AKT pathway","volume":"232","author":"Zhang","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"111734","DOI":"10.1016\/j.cellsig.2025.111734","article-title":"Rhein alleviates diabetic cardiomyopathy by inhibiting mitochondrial dynamics disorder, apoptosis and hypertrophy in cardiomyocytes","volume":"131","author":"Li","year":"2025","journal-title":"Cell Signal"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"115218","DOI":"10.1016\/j.expneurol.2025.115218","article-title":"PPM1D ameliorates Alzheimer\u2019s disease by promoting mitophagy","volume":"388","author":"Wang","year":"2025","journal-title":"Exp Neurol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11064-025-04364-4","article-title":"Costunolide Ameliorates the methylmalonic acidemia Via the PINK1\/Parkin pathway","volume":"50","author":"Lu","year":"2025","journal-title":"Neurochem Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J Cell Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1158\/0008-5472.CAN-20-3477","article-title":"Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer","volume":"81","author":"Ghoochani","year":"2021","journal-title":"Cancer Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12894-024-01585-7","article-title":"Autophagy in benign prostatic hyperplasia: insights and therapeutic potential","volume":"24","author":"Zhou","year":"2024","journal-title":"BMC Urol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"103298","DOI":"10.1016\/j.redox.2024.103298","article-title":"Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p\/GPX4 signal pathway","volume":"75","author":"Zhan","year":"2024","journal-title":"Redox Biol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2020.02.093","article-title":"Down-regulation of IDH2 sensitizes cancer cells to erastin-induced ferroptosis","volume":"525","author":"Kim","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"101418","DOI":"10.1016\/j.redox.2019.101418","article-title":"Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer","volume":"30","author":"Shin","year":"2020","journal-title":"Redox Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","article-title":"Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int J Biol Sci"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41419-021-04367-3","article-title":"Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2\/HO-1 signalling pathway in KRAS mutant colorectal cancer","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41419-024-07015-8","article-title":"Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis","volume":"15","author":"Tang","year":"2024","journal-title":"Cell Death Dis"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.molcel.2024.07.020","article-title":"OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response","volume":"84","author":"Liang","year":"2024","journal-title":"Mol Cell"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"e2716","DOI":"10.1038\/cddis.2017.133","article-title":"Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells","volume":"8","author":"Basit","year":"2017","journal-title":"Cell Death Dis"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41418-024-01280-y","article-title":"Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species","volume":"31","author":"Yamashita","year":"2024","journal-title":"Cell Death Differ"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000366210","article-title":"Oxidative stress in benign prostatic hyperplasia: a systematic review","volume":"94","author":"Minciullo","year":"2015","journal-title":"Urol Int"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1464-410x.2001.02231.x","article-title":"Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma","volume":"88","author":"Baltaci","year":"2001","journal-title":"BJU Int"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<224::AID-PATH422>3.0.CO;2-K","article-title":"Nitric oxide synthases in normal and benign hyperplastic human prostate: immunohistochemistry and molecular biology","volume":"189","author":"Gradini","year":"1999","journal-title":"J Pathol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000315064","article-title":"Oxidative stress in benign prostatic hyperplasia and prostate cancer","volume":"85","author":"Pace","year":"2010","journal-title":"Urol Int"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0891-5849(94)00171-F","article-title":"DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia","volume":"18","author":"Olinski","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41419-022-04522-4","article-title":"Glucose-regulated protein 78 modulates cell growth, epithelial-mesenchymal transition, and oxidative stress in the hyperplastic prostate","volume":"13","author":"Fu","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"e70129","DOI":"10.1002\/mco2.70129","article-title":"Heat shock protein family a member 1A attenuates apoptosis and oxidative stress via ERK\/JNK pathway in hyperplastic prostate","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and diseases: role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol Cell Biochem"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/antiox8100454","article-title":"The role of mitochondria in the mechanisms of cardiac ischemia-reperfusion injury","volume":"8","author":"Kuznetsov","year":"2019","journal-title":"Antioxidants"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3390\/ijms26051953","article-title":"Anti-cancer and pro-immune effects of lauric acid on colorectal cancer cells","volume":"26","author":"Mori","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.3390\/ijms26052241","article-title":"Astaxanthin alleviates oxidative stress in mouse preantral follicles and enhances follicular development through the AMPK signaling pathway","volume":"26","author":"He","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref114","first-page":"64","article-title":"A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function","volume":"46","author":"Yang","year":"2025","journal-title":"J Adv Res"},{"key":"ref115","first-page":"2111","volume":"9","author":"Tuncay","year":"2025","journal-title":"Mol Cell Biochem"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"156600","DOI":"10.1016\/j.phymed.2025.156600","article-title":"Artemetin targets the ABCG2\/RAB7A axis to inhibit mitochondrial dysfunction in asthma","volume":"140","author":"Ding","year":"2025","journal-title":"Phytomedicine"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"gkaf178","DOI":"10.1093\/nar\/gkaf178","article-title":"DNA damage response regulator ATR licenses PINK1-mediated mitophagy","volume":"53","author":"Marx","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12017-025-08843-3","article-title":"The role of G-protein-coupled receptor kinase 4 in modulating mitophagy and oxidative stress in cerebral ischemia-reperfusion injury","volume":"27","author":"Wang","year":"2025","journal-title":"Neuromolecular Med"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/path.5857","article-title":"5-Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia","volume":"256","author":"Joseph","year":"2022","journal-title":"J Pathol"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJM199210223271701","article-title":"The effect of finasteride in men with benign prostatic hyperplasia. the finasteride study group","volume":"327","author":"Gormley","year":"1992","journal-title":"N Engl J Med"},{"key":"ref121","first-page":"1107","article-title":"Subcellular distribution of androgen receptors in human normal, benign hyperplastic, and malignant prostatic tissues: characterization of nuclear salt-resistant receptors","volume":"43","author":"Barrack","year":"1983","journal-title":"Cancer Res"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/00000421-198801102-00004","article-title":"Relationship of androgen receptors to the growth and regression of the prostate","volume":"11 Suppl 2","author":"Rennie","year":"1988","journal-title":"Am J Clin Oncol"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/ijms23020897","article-title":"Heat shock proteins in benign prostatic hyperplasia and prostate cancer","volume":"23","author":"Ratajczak","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000473774","article-title":"Stromal nodules in benign prostatic hyperplasia","volume":"29","author":"Bierhoff","year":"1996","journal-title":"Eur Urol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/pros.21445","article-title":"Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts","volume":"72","author":"Yu","year":"2012","journal-title":"Prostate"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/pros.21264","article-title":"Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells","volume":"71","author":"Yu","year":"2011","journal-title":"Prostate"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"18376","DOI":"10.1074\/jbc.M112.355164","article-title":"Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1016\/j.ajpath.2014.06.022","article-title":"Stromal androgen receptor in prostate development and cancer","volume":"184","author":"Singh","year":"2014","journal-title":"Am J Pathol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2017.05.006","article-title":"Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts","volume":"471","author":"Nash","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1210\/me.2012-1079","article-title":"Targeting androgen receptor to suppress macrophage-induced EMT and benign prostatic hyperplasia (BPH) development","volume":"26","author":"Lu","year":"2012","journal-title":"Mol Endocrinol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/s41388-025-03328-w","article-title":"A mitochondrial outer membrane protein TOMM20 maintains protein stability of androgen receptor and regulates AR transcriptional activity in prostate cancer cells","volume":"44","author":"Yin","year":"2025","journal-title":"Oncogene"}],"container-title":["Canadian Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.techscience.cn\/files\/cju\/2025\/TSP_CJU-32-4\/TSP_CJU_66523\/TSP_CJU_66523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:04:43Z","timestamp":1763345083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/CJU\/v32n4\/63655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":131,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.32604\/cju.2025.066523","relation":{},"ISSN":["1488-5581"],"issn-type":[{"value":"1488-5581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}