{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:11:26Z","timestamp":1776852686821,"version":"3.51.2"},"reference-count":31,"publisher":"Tech Science Press","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/doi.org\/10.32604\/TSP-CROSSMARKPOLICY"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OR"],"published-print":{"date-parts":[[2024]]},"DOI":"10.32604\/or.2024.044029","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:18:01Z","timestamp":1706768281000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.32604\/tsp-crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2"],"prefix":"10.32604","volume":"32","author":[{"given":"HYUNG SUN","family":"KIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUN SUN","family":"LEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEUNG MYUNG","family":"DONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HYO JUNG","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DA EUN","family":"LEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HYEON WOONG","family":"KANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MYEONG JIN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOON SEONG","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17807","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"11469","DOI":"10.3390\/ijms222111469","article-title":"Epithelial to mesenchymal transition: A challenging playground for translational research. Current models and focus on TWIST1 relevance and gastrointestinal cancers","volume":"22","author":"Greco","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/bioe.2019.0013","article-title":"Bioelectric control of metastasis in solid tumors","volume":"1","author":"Payne","year":"2019","journal-title":"Bioelectricity"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-018-0937-3","article-title":"The functional role of integrins during intra- and extravasation within the metastatic cascade","volume":"18","author":"Sokeland","year":"2019","journal-title":"Molecular Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1101\/gad.225334.113","article-title":"Epithelial-mesenchymal plasticity in carcinoma metastasis","volume":"27","author":"Tsai","year":"2013","journal-title":"Genes & Development"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.21037\/atm.2020.02.157","article-title":"Invadopodia: Clearing the way for cancer cell invasion","volume":"8","author":"Augoff","year":"2020","journal-title":"Annals of Translational Medicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.18632\/oncotarget.301","article-title":"Targeting invadopodia to block breast cancer metastasis","volume":"2","author":"Eckert","year":"2011","journal-title":"Oncotarget"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/onc.2013.68","article-title":"Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts","volume":"33","author":"Goicoechea","year":"2014","journal-title":"Oncogene"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcancer.2019.08.003","article-title":"Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator","volume":"62","author":"Karamanou","year":"2020","journal-title":"Seminars in Cancer Biology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"584181","DOI":"10.3389\/fcell.2020.584181","article-title":"Tumor cellular and microenvironmental cues controlling invadopodia formation","volume":"8","author":"Masi","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/15419061.2014.923845","article-title":"Invadopodia, regulation, and assembly in cancer cell invasion","volume":"21","author":"Saykali","year":"2014","journal-title":"Cell Communication & Adhesion"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.febslet.2008.03.039","article-title":"Lamellipodia and filopodia in metastasis and invasion","volume":"582","author":"Machesky","year":"2008","journal-title":"FEBS Letters"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.18632\/oncotarget.164","article-title":"Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis","volume":"1","author":"Yamaguchi","year":"2010","journal-title":"Oncotarget"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1158\/1078-0432.CCR-06-0456","article-title":"The signaling and biological implications of FAK overexpression in cancer","volume":"12","author":"Siesser","year":"2006","journal-title":"Clinical Cancer Research"},{"key":"ref14","first-page":"4779","article-title":"Increased expression of FAK isoforms as potential cancer biomarkers in ovarian cancer","volume":"17","author":"Nolasco-Quiroga","year":"2019","journal-title":"Oncology Letters"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13046-019-1265-1","article-title":"The roles of nuclear focal adhesion kinase (FAK) on cancer: A focused review","volume":"38","author":"Zhou","year":"2019","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s12276-020-0447-4","article-title":"Targeting focal adhesion kinase in cancer cells and the tumor microenvironment","volume":"52","author":"Murphy","year":"2020","journal-title":"Experimental & Molecular Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1442-2050.2009.01035.x","article-title":"The expression of CFL1 and N-WASP in esophageal squamous cell carcinoma and its correlation with clinicopathological features","volume":"23","author":"Wang","year":"2010","journal-title":"Diseases of the Esophagus"},{"key":"ref18","first-page":"403","article-title":"N-WASP promotes invasion and migration of cervical cancer cells through regulating p38 MAPKs signaling pathway","volume":"9","author":"Hou","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1007\/s00268-014-2500-8","article-title":"N-WASP in pancreatic ductal adenocarcinoma: Associations with perineural invasion and poor prognosis","volume":"38","author":"Guo","year":"2014","journal-title":"World Journal of Surgery"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12885-017-3219-3","article-title":"Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion","volume":"17","author":"Frugtniet","year":"2017","journal-title":"BMC Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"42539","DOI":"10.18632\/oncotarget.9918","article-title":"Emerging role of LOXL2 in the promotion of pancreas cancer metastasis","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1083\/jcb.200708123","article-title":"WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells","volume":"180","author":"Sarmiento","year":"2008","journal-title":"Journal of Cell Biology"},{"key":"ref23","first-page":"99","article-title":"Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis","volume":"7","author":"Frugtniet","year":"2015","journal-title":"Breast Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1349-7006.2010.01654.x","article-title":"WASP and WAVE family proteins: Friends or foes in cancer invasion?","volume":"101","author":"Kurisu","year":"2010","journal-title":"Cancer Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1756-0500-5-88","article-title":"Evolution of the eukaryotic ARP2\/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML","volume":"5","author":"Kollmar","year":"2012","journal-title":"BMC Research Notes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1586\/14737140.2015.1058711","article-title":"Invadopodia: A new therapeutic target to block cancer metastasis","volume":"15","author":"Stoletov","year":"2015","journal-title":"Expert Review of Anticancer Therapy"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11933","DOI":"10.1073\/pnas.0701077104","article-title":"Src phosphorylation of cortactin enhances actin assembly","volume":"104","author":"Tehrani","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref28","first-page":"296450","article-title":"Focal adhesion kinases in adhesion structures and disease","volume":"2012","author":"Eleniste","year":"2012","journal-title":"Journal of Receptors and Signal Transduction"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00021.2007","article-title":"Regulation of actin assembly associated with protrusion and adhesion in cell migration","volume":"88","author":"Le Clainche","year":"2008","journal-title":"Physiological Reviews"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrm3141","article-title":"The \u2018ins\u2019 and \u2018outs\u2019 of podosomes and invadopodia: Characteristics, formation and function","volume":"12","author":"Murphy","year":"2011","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1158\/1541-7786.MCR-13-0033-T","article-title":"Tumor-secreted LOXL2 activates fibroblasts through FAK signaling","volume":"11","author":"Baker","year":"2013","journal-title":"Molecular Cancer Research"}],"container-title":["Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.techscience.com\/files\/or\/2024\/TSP_OR-32-4\/OncolRes-32-04-44029\/OncolRes-32-44029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:35:29Z","timestamp":1741242929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/or\/v32n4\/55761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.32604\/or.2024.044029","relation":{},"ISSN":["1555-3906"],"issn-type":[{"value":"1555-3906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"2023-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","order":2,"name":"published","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}