{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:56:59Z","timestamp":1767203819042,"version":"build-2238731810"},"update-to":[{"DOI":"10.32604\/or.2024.046231","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000}}],"reference-count":26,"publisher":"Tech Science Press","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/doi.org\/10.32604\/TSP-CROSSMARKPOLICY"}],"content-domain":{"domain":["www.techscience.com"],"crossmark-restriction":false},"short-container-title":["OR"],"published-print":{"date-parts":[[2024]]},"DOI":"10.32604\/or.2024.046231","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T08:22:21Z","timestamp":1707726141000},"page":"679-690","update-policy":"https:\/\/doi.org\/10.32604\/tsp-crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma"],"prefix":"10.32604","volume":"32","author":[{"given":"XINFENG","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEIRU","family":"SONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUE","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIANGZHENG","family":"CHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHERUI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONGYUAN","family":"DAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUTAO","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GANGQI","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUN","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YINYING","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17807","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cell.2019.11.031","article-title":"Proteolysis-targeting chimeras as therapeutics and tools for biological discovery","volume":"181","author":"Burslem","year":"2020","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10585-010-9306-3","article-title":"FAK is involved in invasion and metastasis of hepatocellular carcinoma","volume":"27","author":"Chen","year":"2010","journal-title":"Clinical & Experimental Metastasis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1021\/jacs.8b08008","article-title":"Addressing kinase-independent functions of Fak via PROTAC-mediated degradation","volume":"140","author":"Cromm","year":"2018","journal-title":"Journal of the American Chemical Society"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.2147\/OTT.S150456","article-title":"Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway","volume":"10","author":"Cui","year":"2017","journal-title":"OncoTargets and Therapy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41568-021-00340-6","article-title":"Targeting FAK in anticancer combination therapies","volume":"21","author":"Dawson","year":"2021","journal-title":"Nature Reviews Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1038\/s41467-019-11429-w","article-title":"Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations","volume":"10","author":"de Wispelaere","year":"2019","journal-title":"Nature Communications"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1021\/acsmedchemlett.9b00372","article-title":"Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs","volume":"11","author":"Gao","year":"2020","journal-title":"ACS Medicinal Chemistry Letters"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s13238-020-00732-8","article-title":"FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice","volume":"11","author":"Gao","year":"2020","journal-title":"Protein & Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/cdd.2017.34","article-title":"Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2","volume":"24","author":"Gnani","year":"2017","journal-title":"Cell Death & Differentiation"},{"key":"ref10","first-page":"2453","article-title":"Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration","volume":"8","author":"Guo","year":"2018","journal-title":"American Journal of Cancer Research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-022-00999-9","article-title":"PROTACs: Great opportunities for academia and industry (an update from 2020 to 2021)","volume":"7","author":"He","year":"2022","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/CIRCRESAHA.118.314344","article-title":"Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and Neointimal Hyperplasia through GATA4-mediated cyclin D1 transcription","volume":"125","author":"Jeong","year":"2019","journal-title":"Circulation Research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.7150\/thno.27246","article-title":"Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin \u03b23\/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery","volume":"9","author":"Jin","year":"2019","journal-title":"Theranostics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.7150\/thno.46985","article-title":"The peptide PROTAC modality: A novel strategy for targeted protein ubiquitination","volume":"10","author":"Jin","year":"2020","journal-title":"Theranostics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10059-013-0139-1","article-title":"Nuclear FAK: A new mode of gene regulation from cellular adhesions","volume":"36","author":"Lim","year":"2013","journal-title":"Molecules and Cells"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1002\/cam4.1777","article-title":"Focal adhesion kinase activation limits efficacy of Dasatinib in c-Myc driven hepatocellular carcinoma","volume":"7","author":"Liu","year":"2018","journal-title":"Cancer Medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejro.2014.07.001","article-title":"Current update on combined hepatocellular-cholangiocarcinoma","volume":"1","author":"Maximin","year":"2014","journal-title":"European Journal of Radiology Open"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1021\/acs.jmedchem.8b01826","article-title":"Highly selective PTK2 proteolysis targeting chimeras to probe focal adhesion kinase scaffolding functions","volume":"62","author":"Popow","year":"2019","journal-title":"Journal of Medicinal Chemistry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/etm_00000082","article-title":"Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma","volume":"1","author":"Qiu","year":"2010","journal-title":"Experimental and Therapeutic Medicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1158\/1078-0432.CCR-14-2021","article-title":"Molecular pathways: Endothelial cell FAK\u2013A target for cancer treatment","volume":"22","author":"Roy-Luzarraga","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/CIRCRESAHA.107.163642","article-title":"Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog","volume":"102","author":"Sabri","year":"2008","journal-title":"Circulation Research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12935-022-02538-6","article-title":"NCAPG facilitates colorectal cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the Wnt\/\u03b2-catenin signaling pathway","volume":"22","author":"Shi","year":"2022","journal-title":"Cancer Cell International"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1093\/annonc\/mdw427","article-title":"A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors","volume":"27","author":"Soria","year":"2016","journal-title":"Annals of Oncology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.7150\/jca.61066","article-title":"A luminacin D analog HL142 inhibits ovarian tumor growth and metastasis by reversing EMT and attenuating the TGF\u03b2 and FAK pathways","volume":"12","author":"Wang","year":"2021","journal-title":"Journal of Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yexcr.2014.05.018","article-title":"Heat shock protein 90\u03b2 stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells","volume":"326","author":"Xiong","year":"2014","journal-title":"Experimental Cell Research"}],"updated-by":[{"DOI":"10.32604\/or.2024.046231","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000}}],"container-title":["Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.techscience.cn\/uploads\/attached\/file\/20240411\/20240411173338_91806.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T01:36:22Z","timestamp":1741224982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/or\/v32n4\/55765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.32604\/or.2024.046231","relation":{},"ISSN":["1555-3906"],"issn-type":[{"value":"1555-3906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}