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Prod"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1111\/j.1753-4887.1996.tb03821.x","article-title":"Japanese green tea as a cancer preventive in humans","volume":"54","author":"Fujiki","year":"1996","journal-title":"Nutr Rev"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1158\/1940-6207.CAPR-14-0324","article-title":"Randomized, placebo-controlled trial of green tea catechins for prostate cancer prevention","volume":"8","author":"Kumar","year":"2015","journal-title":"Cancer Prev Res"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ygyno.2013.08.019","article-title":"A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer","volume":"131","author":"Trudel","year":"2013","journal-title":"Gynecol 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compounds in breast cancer prevention and treatment","volume":"5","author":"Li","year":"2014","journal-title":"World J Clin Oncol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/jhn.12229","article-title":"Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer","volume":"28","author":"Crew","year":"2015","journal-title":"J Hum Nutr Diet"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jn\/nxaa315","article-title":"Combined broccoli sprouts and green tea polyphenols contribute to the prevention of estrogen receptor-negative mammary cancer via cell cycle arrest and inducing apoptosis in HER2\/neu mice","volume":"151","author":"Li","year":"2021","journal-title":"J Nutr"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"728663","DOI":"10.3389\/fcell.2021.728663","article-title":"Monitoring spontaneous quiescence and asynchronous proliferation-quiescence decisions in prostate cancer cells","volume":"9","author":"Pulianmackal","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/bbrc.2000.2536","article-title":"Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells","volume":"270","author":"Islam","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2016.02.012","article-title":"Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research","volume":"182","author":"Tao","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11627-007-9055-4","article-title":"Medicinal biotechnology in the genus Scutellaria","volume":"43","author":"Cole","year":"2007","journal-title":"Vitro Cell Dev Biol Plant"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"7265445","DOI":"10.1155\/2022\/7265445","article-title":"A background search on the potential role of Scutellaria and its essential oils","volume":"2022","author":"Zehravi","year":"2022","journal-title":"Biomed Res Int"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"109340","DOI":"10.18632\/oncotarget.22677","article-title":"The anti-cancer effects and mechanisms of Scutellaria barbata D. 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