{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:05:53Z","timestamp":1787025953282,"version":"build-2736575974"},"reference-count":191,"publisher":"Tech Science Press","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OR"],"published-print":{"date-parts":[[2025]]},"DOI":"10.32604\/or.2025.064677","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:00:21Z","timestamp":1751601621000},"page":"2221-2242","source":"Crossref","is-referenced-by-count":5,"title":["Targeting TAMs & CAFs in melanoma: New approaches to tumor microenvironment therapy"],"prefix":"10.32604","volume":"33","author":[{"given":"Yuriy","family":"Mayasin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Osinnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Osadchaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Dmitrienko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gorodilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulpan","family":"Kharisova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Kitaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Filin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Solovyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Rizvanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17807","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","first-page":"91","article-title":"Histopathological diagnosis of malignant melanoma at the dawn of 2023: knowledge gained and new challenges","volume":"10","author":"Cazzato","year":"2023","journal-title":"Dermatopath Multidiscip Digit Publish Instit"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1512942","DOI":"10.3389\/fonc.2024.1512942","article-title":"Global, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045","volume":"14","author":"Liu","year":"2024","journal-title":"Front Oncol Frontiers"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","article-title":"Global burden of cutaneous melanoma in 2020 and projections to 2040","volume":"158","author":"Arnold","year":"2022","journal-title":"JAMA Dermatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.3390\/cancers15123224","article-title":"New approaches to targeted therapy in melanoma","volume":"15","author":"Fernandez","year":"2023","journal-title":"Cancers"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/ijms22020529","article-title":"Stromal cells present in the melanoma niche affect tumor invasiveness and its resistance to therapy","volume":"22","author":"Mazurkiewicz","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref6","first-page":"3147","article-title":"Tumor microenvironment as a therapeutic target in melanoma treatment","volume":"15","author":"Kharouf","year":"2023","journal-title":"Cancers Multidiscip Dig Publis Instit"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e202212031","DOI":"10.1083\/jcb.202212031","article-title":"Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration","volume":"222","author":"Burks","year":"2023","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"858425","DOI":"10.3389\/fonc.2022.858425","article-title":"The inflammatory status of soluble microenvironment influences the capacity of melanoma cells to control T-cell responses","volume":"12","author":"Bog\u00e9a","year":"2022","journal-title":"Front Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"112832","DOI":"10.1016\/j.biopha.2022.112832","article-title":"Tumor-derived exosomes: the emerging orchestrators in melanoma","volume":"149","author":"Tan","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1061982","DOI":"10.3389\/fcell.2022.1061982","article-title":"Extracellular vesicles and melanoma: new perspectives on tumor microenvironment and metastasis","volume":"10","author":"Benito-Mart\u00edn","year":"2023","journal-title":"Front Cell Dev Biol Frontiers"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s12964-024-01820-6","article-title":"Extracellular vesicles from highly invasive melanoma subpopulations increase the invasive capacity of less invasive melanoma cells through mir-1246-mediated inhibition of CCNG2","volume":"22","author":"Kingreen","year":"2024","journal-title":"Cell Commun Signal"},{"key":"ref12","first-page":"326","article-title":"Role of miRNAs in melanoma metastasis","volume":"11","author":"Gajos-Michniewicz","year":"2019","journal-title":"Cancers Multidiscip Digit Publish Instit"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.actbio.2024.11.018","article-title":"Characterization of human melanoma skin cancer models: a step towards model-based melanoma research","volume":"191","author":"Daugaard","year":"2025","journal-title":"Acta Biomater"},{"key":"ref14","first-page":"443","article-title":"Melanoma\u2019s connections to the tumour microenvironment","volume":"45","author":"Brandner","year":"2013","journal-title":"Pathology Elsevier"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"924553","DOI":"10.3389\/fonc.2022.924553","article-title":"Role of extracellular matrix architecture and signaling in melanoma therapeutic resistance","volume":"12","author":"Popovic","year":"2022","journal-title":"Front Oncol Frontiers"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41392-021-00827-6","article-title":"Signal pathways of melanoma and targeted therapy","volume":"6","author":"Guo","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12935-022-02738-0","article-title":"Current understanding of epigenetics role in melanoma treatment and resistance","volume":"22","author":"Karami Fath","year":"2022","journal-title":"Cancer Cell Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/jdv.19881","article-title":"Spatial transcriptomic analysis of tumour-immune cell interactions in melanoma arising from congenital melanocytic nevus","volume":"38","author":"Lim","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.3390\/ijms21218359","article-title":"The influence of tumor microenvironment on immune escape of melanoma","volume":"21","author":"Simiczyjew","year":"2020","journal-title":"Int J Molec Sci Multidiscip Digit Publis Instit"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12967-020-02235-w","article-title":"Poor clinical outcome in metastatic melanoma is associated with a microRNA-modulated immunosuppressive tumor microenvironment","volume":"18","author":"Jorge","year":"2020","journal-title":"J Transl Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1158\/0008-5472.CAN-06-0731","article-title":"Influence of the microenvironment on melanoma cell fate determination and phenotype","volume":"66","author":"Postovit","year":"2006","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jss.2021.05.008","article-title":"A retrospective, observational analysis of tumor infiltrating lymphocytes and tumor regression in melanoma","volume":"267","author":"Zaladonis","year":"2021","journal-title":"J Surg Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.clindermatol.2012.08.017","article-title":"Immunology of melanoma","volume":"31","author":"Mukherji","year":"2013","journal-title":"Clin Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"119493","DOI":"10.1016\/j.bbamcr.2023.119493","article-title":"Role of neutrophils on cancer cells and other immune cells in the tumor microenvironment","volume":"1870","author":"Zhong","year":"2023","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3892\/etm.2022.11577","article-title":"Macrophages in melanoma: a double-edged sword and targeted therapy strategies (Review)","volume":"24","author":"Zhou","year":"2022","journal-title":"Exp Ther Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"101481","DOI":"10.1016\/j.smim.2021.101481","article-title":"The role of dendritic cells in cancer and anti-tumor immunity","volume":"52","author":"Marciscano","year":"2021","journal-title":"Semin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/CMR.0b013e3281844531","article-title":"Melanoma-infiltrating dendritic cells induce protective antitumor responses mediated by T-cells","volume":"17","author":"Preynat-Seauve","year":"2007","journal-title":"Melanoma Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12935-023-03134-y","article-title":"The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies","volume":"23","author":"Rahimi","year":"2023","journal-title":"Cancer Cell Int"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12943-024-02208-3","article-title":"Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy","volume":"24","author":"He","year":"2025","journal-title":"Mol Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.3390\/cancers13235972","article-title":"Role of tumor-associated neutrophils in the molecular carcinogenesis of the lung","volume":"13","author":"Taucher","year":"2021","journal-title":"Cancers"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41423-023-00990-6","article-title":"Dendritic cell subsets in cancer immunity and tumor antigen sensing","volume":"20","author":"Del Prete","year":"2023","journal-title":"Cell Mol Immunol Nature Publish Group"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"702726","DOI":"10.3389\/fimmu.2021.702726","article-title":"Regulatory T cells: barriers of immune infiltration into the tumor microenvironment","volume":"12","author":"Scott","year":"2021","journal-title":"Front Immunol Frontiers"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/cei\/uxac029","article-title":"Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses","volume":"209","author":"Flores-Borja","year":"2022","journal-title":"Clin Experim Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","article-title":"Cancer-associated fibroblasts: from basic science to anticancer therapy","volume":"55","author":"Yang","year":"2023","journal-title":"Exp Mol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/SAP.0000000000003658","article-title":"Understanding the role of adipocytes and fibroblasts in cancer","volume":"91","author":"Downer","year":"2023","journal-title":"Ann Plast Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.3390\/ijms25168813","article-title":"Contribution of keratinocytes in skin cancer initiation and progression","volume":"25","author":"Dainese-Marque","year":"2024","journal-title":"Int J Molec Sci Multidiscip Digit Publish Instit"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.3390\/cancers14174216","article-title":"Melanoma tumour vascularization and tissue-resident endothelial progenitor cells","volume":"14","author":"Hashemi","year":"2022","journal-title":"Cancers"},{"key":"ref39","first-page":"146","article-title":"The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis","volume":"8","author":"Dzobo","year":"2023","journal-title":"Biomimetics Multidiscip Digit Publish Instit"},{"key":"ref40","first-page":"2057","article-title":"The matrix reloaded\u2014the role of the extracellular matrix in cancer","volume":"15","author":"Raskov","year":"2023","journal-title":"Cancers Multidiscip Digit Publish Instit"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1406644","DOI":"10.3389\/fonc.2024.1406644","article-title":"Multiple aspects of matrix stiffness in cancer progression","volume":"14","author":"Mancini","year":"2024","journal-title":"Front Oncol"},{"key":"ref42","first-page":"1917","article-title":"Extracellular matrix as a target in melanoma therapy: from hypothesis to clinical trials","volume":"13","author":"Mayasin","year":"2024","journal-title":"Cells Multidiscipl Digit Publish Instit"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"ref44","first-page":"162","article-title":"Tumor and immunity","volume":"45","author":"Kazbarien\u0117","year":"2009","journal-title":"Medicina Multidiscipl Digit Publish Instit"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3389\/fimmu.2020.01633","article-title":"Re-education of the tumor microenvironment with targeted therapies and immunotherapies","volume":"11","author":"Ngiow","year":"2020","journal-title":"Front Immunol Frontiers"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1080\/1061186X.2024.2384071","article-title":"Targeting anticancer immunity in melanoma tumour microenvironment: unleashing the potential of adjuvants, drugs, and phytochemicals","volume":"32","author":"Wang","year":"2024","journal-title":"J Drug Target Taylor Francis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"166746","DOI":"10.1016\/j.bbadis.2023.166746","article-title":"Targeting the tumor microenvironment: potential strategy for cancer therapeutics","volume":"1869","author":"Babar","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.4769","article-title":"Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development","volume":"240","author":"Hashimoto","year":"2016","journal-title":"J Pathol"},{"key":"ref49","first-page":"119464","article-title":"Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts","volume":"14","author":"Timperi","year":"2023","journal-title":"Front Immunol Frontiers"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/cas.15609","article-title":"The heterogeneity of cancer-associated fibroblast subpopulations: their origins, biomarkers, and roles in the tumor microenvironment","volume":"114","author":"Yamamoto","year":"2023","journal-title":"Cancer Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1158\/1078-0432.CCR-24-1690","article-title":"At the interface of tumor-associated macrophages and fibroblasts: immune-suppressive networks and emerging exploitable targets","volume":"30","author":"Timperi","year":"2024","journal-title":"Clin Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"188356","DOI":"10.1016\/j.bbcan.2020.188356","article-title":"Fibrosis and cancer: a strained relationship","volume":"1873","author":"Piersma","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2020.05.006","article-title":"Fibroblasts: the arbiters of extracellular matrix remodeling","volume":"91\u201392","author":"DeLeon-Pennell","year":"2020","journal-title":"Matrix Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"719922","DOI":"10.3389\/fonc.2021.719922","article-title":"Regulation of extracellular matrix production in activated fibroblasts: roles of amino acid metabolism in collagen synthesis","volume":"11","author":"Kay","year":"2021","journal-title":"Front Oncol Frontiers"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"dev175596","DOI":"10.1242\/dev.175596","article-title":"The extracellular matrix in development","volume":"147","author":"Walma","year":"2020","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix","volume":"288","author":"Karamanos","year":"2021","journal-title":"FEBS J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jtv.2009.11.004","article-title":"Fibroblasts and myofibroblasts in wound healing: force generation and measurement","volume":"20","author":"Li","year":"2011","journal-title":"J Tissue Viability"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.12968\/jowc.2013.22.8.407","article-title":"Wound healing and the role of fibroblasts","volume":"22","author":"Bainbridge","year":"2013","journal-title":"J Wound Care"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1137659","DOI":"10.3389\/fimmu.2023.1137659","article-title":"Fibroblast heterogeneity: keystone of tissue homeostasis and pathology in inflammation and ageing","volume":"14","author":"Gauthier","year":"2023","journal-title":"Front Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e149538","DOI":"10.1172\/JCI149538","article-title":"Fibroblast pathology in inflammatory diseases","volume":"131","author":"Wei","year":"2021","journal-title":"J Clin Invest"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"110567","DOI":"10.1016\/j.cellsig.2022.110567","article-title":"Cancer-associated fibroblasts: versatile mediators in remodeling the tumor microenvironment","volume":"103","author":"Zhang","year":"2023","journal-title":"Cell Signal"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/cancers15061899","article-title":"Cancer-associated fibroblasts: master tumor microenvironment modifiers","volume":"15","author":"Wright","year":"2023","journal-title":"Cancers"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1158\/0008-5472.CAN-14-0350","article-title":"Twist1 is a key regulator of cancer-associated fibroblasts","volume":"75","author":"Lee","year":"2015","journal-title":"Cancer Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1158\/0008-5472.CAN-12-1097","volume":"72","author":"Vicent","year":"2012","journal-title":"Cancer Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1541-7786.MCR-17-0784","article-title":"Exosomes induce fibroblast differentiation into cancer-associated fibroblasts through TGF\u03b2 signaling","volume":"16","author":"Ringuette Goulet","year":"2018","journal-title":"Mol Cancer Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1158\/0008-5472.CAN-10-1722","article-title":"Cancer exosomes trigger fibroblast to myofibroblast differentiation","volume":"70","author":"Webber","year":"2010","journal-title":"Cancer Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"839880","DOI":"10.3389\/fonc.2022.839880","article-title":"Tumor-derived extracellular vesicles activate normal human fibroblasts to a cancer-associated fibroblast-like phenotype, sustaining a pro-tumorigenic microenvironment","volume":"12","author":"Giusti","year":"2022","journal-title":"Front Oncol Frontiers"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1034205","DOI":"10.3389\/fonc.2023.1034205","article-title":"Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival","volume":"13","author":"Singh","year":"2023","journal-title":"Front Oncol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3390\/cancers14143321","article-title":"Cancer-associated fibroblasts in the hypoxic tumor microenvironment","volume":"14","author":"Kim","year":"2022","journal-title":"Cancers"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1158\/0008-5472.CAN-13-1720","article-title":"Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach","volume":"73","author":"Kim","year":"2013","journal-title":"Cancer Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/pcmr.12545","article-title":"Melanoma niche formation: it is all about melanosomes making CAFs","volume":"30","author":"Anelli","year":"2017","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ncb3404","article-title":"Melanosomes foster a tumour niche by activating CAFs","volume":"18","author":"Garc\u00eda-Silva","year":"2016","journal-title":"Nat Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.3390\/ijms20092256","article-title":"Activated fibroblast program orchestrates tumor initiation and progression; molecular mechanisms and the associated therapeutic strategies","volume":"20","author":"Yoshida","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e1700167","DOI":"10.1002\/pmic.201700167","article-title":"Cancer associated fibroblasts: the architects of stroma remodeling","volume":"18","author":"Santi","year":"2018","journal-title":"Proteomics"},{"key":"ref76","first-page":"3906","article-title":"Cancer-associated fibroblasts: tumorigenicity and targeting for cancer therapy","volume":"14","author":"Glabman","year":"2022","journal-title":"Cancers Multidiscip Digit Publish Instit"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"217475","DOI":"10.1016\/j.canlet.2025.217475","article-title":"FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity","volume":"612","author":"Wei","year":"2025","journal-title":"Cancer Lett"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"33472","DOI":"10.18632\/oncotarget.8098","article-title":"The application of the fibroblast activation protein \u03b1-targeted immunotherapy strategy","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"ref79","first-page":"3203","article-title":"Fibroblast activation protein \u03b1 in tumor microenvironment: recent progression and implications (Review)","volume":"11","author":"Zi","year":"2015","journal-title":"Molecul Medic Rep. Spandidos Publicat"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/prca.201300095","article-title":"Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy","volume":"8","author":"Hamson","year":"2014","journal-title":"Proteomics Clin Appl"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2141.2008.07241.x","article-title":"Fibroblast activation protein alpha identifies mesenchymal stromal cells from human bone marrow","volume":"142","author":"Bae","year":"2008","journal-title":"Br J Haematol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20130110","article-title":"Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia","volume":"210","author":"Tran","year":"2013","journal-title":"J Exp Med"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/sj.onc.1207730","article-title":"FAP\u03b1, a surface peptidase expressed during wound healing, is a tumor suppressor","volume":"23","author":"Ramirez-Montagut","year":"2004","journal-title":"Oncogene"},{"key":"ref84","first-page":"201","article-title":"Promotion of cellular growth and motility is independent of enzymatic activity of fibroblast activation protein-\u03b1","volume":"13","author":"Lv","year":"2016","journal-title":"Cancer Genom Proteom"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yexmp.2013.06.007","article-title":"Fibroblast activation protein-\u03b1 promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms","volume":"95","author":"Yang","year":"2013","journal-title":"Exp Mol Pathol"},{"key":"ref86","first-page":"275","article-title":"Fibroblast activation protein-\u03b1 promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways","volume":"41","author":"Jia","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"648187","DOI":"10.3389\/fonc.2021.648187","article-title":"Fibroblast activation protein-\u03b1 as a target in the bench-to-bedside diagnosis and treatment of tumors: a narrative review","volume":"11","author":"Xin","year":"2021","journal-title":"Front Oncol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.1073\/pnas.87.21.8296","article-title":"A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells","volume":"87","author":"Aoyama","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e12509","DOI":"10.1002\/jev2.12509","article-title":"Extracellular vesicles derived from melanoma cells induce carcinoma-associated fibroblasts via miR-92b-3p mediated downregulation of PTEN","volume":"13","author":"Kewitz-Hempel","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/mp200421k","article-title":"Fibroblasts contribute to melanoma tumour growth and drug resistance","volume":"8","author":"Flach","year":"2011","journal-title":"Mol Pharm"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1517\/14728222.2011.639361","article-title":"The RAS\/RAF\/MEK\/ERK and the PI3K\/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches","volume":"16","author":"De Luca","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.advms.2015.04.006","volume":"60","author":"Teichgr\u00e4ber","year":"2015","journal-title":"Adv Med Sci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.trecan.2022.03.001","article-title":"Targeting CAFs to overcome anticancer therapeutic resistance","volume":"8","author":"Saw","year":"2022","journal-title":"Trends Cancer"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1158\/0008-5472.CAN-04-0447","article-title":"PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism","volume":"64","author":"Adams","year":"2004","journal-title":"Cancer Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"8070","DOI":"10.1074\/jbc.M115.701433","article-title":"Fibroblast activation protein (FAP) accelerates collagen degradation and clearance from lungs in mice","volume":"291","author":"Fan","year":"2016","journal-title":"J Biol Chem"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha","volume":"330","author":"Kraman","year":"2010","journal-title":"Science"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1517\/13543784.16.9.1459","article-title":"Talabostat","volume":"16","author":"Cunningham","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"key":"ref98","first-page":"7570","article-title":"Phase 2 trial of talabostat in stage IV melanoma","volume":"23","author":"Redman","year":"2005","journal-title":"JCO Wolters Kluwer"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/1471-2407-9-263","article-title":"Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma","volume":"9","author":"Eager","year":"2009","journal-title":"BMC Cancer"},{"key":"ref100","first-page":"8040","article-title":"Phase 2 trial of talabostat and cisplatin in patients with stage IV melanoma","volume":"24","author":"Cunningham","year":"2006","journal-title":"JCO Wolters Kluwer"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1158\/1078-0432.CCR-12-0644","article-title":"Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies","volume":"18","author":"Fischer","year":"2012","journal-title":"Clinic Cancer Res"},{"key":"ref102","first-page":"e15155","article-title":"Safety, PK\/PD, and anti-tumor activity of RO6874281, an engineered variant of interleukin-2 (IL-2v) targeted to tumor-associated fibroblasts via binding to fibroblast activation protein (FAP)","volume":"36","author":"Soerensen","year":"2018","journal-title":"JCO Wolters Kluwer"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1913791","DOI":"10.1080\/19420862.2021.1913791","article-title":"Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy","volume":"13","author":"Waldhauer","year":"2021","journal-title":"MAbs"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.trsl.2015.07.008","article-title":"Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives","volume":"168","author":"Constantino","year":"2016","journal-title":"Transl Res"},{"key":"ref105","first-page":"417","article-title":"Clinical implications of co-inhibitory molecule expression in the tumor microenvironment for DC vaccination: a game of stop and go","volume":"4","author":"Vasaturo","year":"2013","journal-title":"Front Immunol Frontiers"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"e82658","DOI":"10.1371\/journal.pone.0082658","article-title":"A vaccine that co-targets tumor cells and cancer associated fibroblasts results in enhanced antitumor activity by inducing antigen spreading","volume":"8","author":"Gottschalk","year":"2013","journal-title":"PLoS One"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"11156","DOI":"10.1158\/0008-5472.CAN-05-2805","article-title":"Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts","volume":"65","author":"Lee","year":"2005","journal-title":"Cancer Res"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/cas.12584","article-title":"Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine","volume":"106","author":"Ohshio","year":"2015","journal-title":"Cancer Sci"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"14421","DOI":"10.1038\/srep14421","article-title":"A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts","volume":"5","author":"Chen","year":"2015","journal-title":"Sci Rep"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1080\/21691401.2019.1687498","article-title":"Anti-tumour effects of a xenogeneic fibroblast activation protein-based whole cell tumour vaccine in murine tumour models","volume":"47","author":"Chen","year":"2019","journal-title":"Artif Cells, Nanomed Biotechnol Taylor Francis"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1182\/blood-2008-07-144485","article-title":"The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology","volume":"113","author":"Curti","year":"2009","journal-title":"Blood"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1182\/blood.V92.10.3730","article-title":"Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor","volume":"92","author":"Liu","year":"1998","journal-title":"Blood"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"25932","DOI":"10.18632\/oncotarget.4577","article-title":"Curcumin combined with FAP\u03b1c vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-\u03b1 in melanoma","volume":"6","author":"Jiang","year":"2015","journal-title":"Oncotarget Impact J"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1172\/JCI26532","article-title":"Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake","volume":"116","author":"Loeffler","year":"2006","journal-title":"J Clin Invest"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"23282","DOI":"10.18632\/oncotarget.7818","article-title":"Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T-cells within tumors","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s13402-021-00593-1","article-title":"CAR T-cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities","volume":"44","author":"Akhoundi","year":"2021","journal-title":"Cell Oncol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/exd.13792","article-title":"CAR-T-cell therapy in melanoma: a future success story?","volume":"27","author":"Simon","year":"2018","journal-title":"Exp Dermatol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"958082","DOI":"10.3389\/fimmu.2022.958082","article-title":"Development of Nectin4\/FAP-targeted CAR-T-cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2967\/jnumed.123.266345","article-title":"Preclinical development of PNT6555, a boronic acid-based, fibroblast activation protein-\u03b1 (FAP)\u2013targeted radiotheranostic for imaging and treatment of FAP-positive tumors","volume":"65","author":"Poplawski","year":"2024","journal-title":"J Nucl Med Soc Nucl Med"},{"key":"ref120","first-page":"TPS3161","article-title":"FRONTIER: FAPi radioligand open-label, phase 1 study to evaluate safety, tolerability and dosimetry of [Lu-177]-PNT6555\u2014a dose escalation study for treatment of patients with select solid tumors","volume":"41","author":"Bodei","year":"2023","journal-title":"JCO Wolters Kluwer"},{"key":"ref121","first-page":"241162","article-title":"FRONTIER: FAPi Radioligand OpeN-label, phase 1 study to evaluate safety, Tolerability and dosImetry of [Lu-177]-PNT6555; a dose Escalation study for treatment of patients with select solid tumors","volume":"65","author":"Juneau","year":"2024","journal-title":"J Nucl Med Soc Nucl Med"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00259-022-05702-2","volume":"49","author":"Mokoala","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref123","first-page":"69","article-title":"CAFs interacting with TAMs in tumor microenvironment to enhance tumorigenesis and immune evasion","volume":"11","author":"Gunaydin","year":"2021","journal-title":"Front Oncol Frontiers"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"175087","DOI":"10.1016\/j.ejphar.2022.175087","article-title":"Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?","volume":"928","author":"Tajaldini","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"583084","DOI":"10.3389\/fimmu.2020.583084","article-title":"Tumor-associated macrophages in tumor immunity","volume":"11","author":"Pan","year":"2020","journal-title":"Front Immunol"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1295257","DOI":"10.3389\/fimmu.2023.1295257","article-title":"Tumor-associated macrophages: an effective player of the tumor microenvironment","volume":"14","author":"Basak","year":"2023","journal-title":"Front Immunol"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.immuni.2022.10.002","article-title":"Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer","volume":"55","author":"Nixon","year":"2022","journal-title":"Immunity"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"108875","DOI":"10.1016\/j.clim.2021.108875","article-title":"Macrophages in tumor: an inflammatory perspective","volume":"232","author":"Goswami","year":"2021","journal-title":"Clin Immunol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2009.02.011","article-title":"Role of macrophages in tumour progression","volume":"123","author":"Siveen","year":"2009","journal-title":"Immunol Lett"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41423-023-01061-6","article-title":"Roles of macrophages in tumor development: a spatiotemporal perspective","volume":"20","author":"Bied","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.4049\/jimmunol.1201889","article-title":"Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function","volume":"189","author":"Grugan","year":"2012","journal-title":"J Immunol"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ccell.2021.08.005","article-title":"Activating a collaborative innate-adaptive immune response to control metastasis","volume":"39","author":"Sun","year":"2021","journal-title":"Cancer Cell"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/cells10040903","article-title":"Embryonic origin and subclonal evolution of tumor-associated macrophages imply preventive care for cancer","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3390\/cells13171428","article-title":"Roles of M1 macrophages and their extracellular vesicles in cancer therapy","volume":"13","author":"Zhou","year":"2024","journal-title":"Cells"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s12935-021-02089-2","article-title":"New insights into M1\/M2 macrophages: key modulators in cancer progression","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1016\/j.jid.2022.04.024","article-title":"M1 macrophages induce protumor inflammation in melanoma cells through TNFR-NF-\u03baB signaling","volume":"142","author":"Kainulainen","year":"2022","journal-title":"J Invest Dermatol"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"e28332","DOI":"10.1016\/j.heliyon.2024.e28332","article-title":"Macrophage diversity in human cancers: new insight provided by single-cell resolution and spatial context","volume":"10","author":"Rakina","year":"2024","journal-title":"Heliyon"},{"key":"ref139","first-page":"6995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int J Molecul Sci Multidiscipl Digit Publish Instit"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.it.2022.04.008","article-title":"Macrophage diversity in cancer revisited in the era of single-cell omics","volume":"43","author":"Ma","year":"2022","journal-title":"Trends Immunol"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1264774","DOI":"10.3389\/fimmu.2023.1264774","article-title":"Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing","volume":"14","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-023-04688-1","article-title":"Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T-cells promotes an immunosuppressive environment in gastric metastatic cancer","volume":"22","author":"Du","year":"2024","journal-title":"J Transl Med"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"101568","DOI":"10.1016\/j.tranon.2022.101568","article-title":"Single-cell RNA sequencing analysis revealed cellular and molecular immune profiles in lung squamous cell carcinoma","volume":"27","author":"Hao","year":"2022","journal-title":"Transl Oncol"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41467-022-29366-6","volume":"13","author":"Qi","year":"2022","journal-title":"Nat Commun"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"e007441","DOI":"10.1136\/jitc-2023-007441","volume":"11","author":"Zhang","year":"2023","journal-title":"J Immunother Cancer BMJ Special J"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12967-023-04038-1","article-title":"Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases","volume":"21","author":"Chen","year":"2023","journal-title":"J Transl Med"},{"key":"ref147","doi-asserted-by":"crossref","first-page":"34758","DOI":"10.18632\/oncotarget.5325","article-title":"CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget Impact J"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.4049\/jimmunol.177.4.2691","article-title":"Monocyte-derived human macrophages mediate anergy in allogeneic T-cells and induce regulatory T-cells","volume":"177","author":"Hoves","year":"2006","journal-title":"J Immunol"},{"key":"ref149","first-page":"A1012","article-title":"896 VCAM-1+ tumor associated macrophages form perivascular tumor niches and drive resistance to anti-CTLA-4 therapy","volume":"12","author":"Herbrich","year":"2024","journal-title":"J Immunother Canc BMJ Special J"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J Hematol Oncol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"e50946","DOI":"10.1371\/journal.pone.0050946","article-title":"Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"ref152","doi-asserted-by":"crossref","first-page":"114548","DOI":"10.1016\/j.biopha.2023.114548","article-title":"Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels","volume":"161","author":"Peraza","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/eji.202149379","article-title":"Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy","volume":"51","author":"Belgiovine","year":"2021","journal-title":"Eur J Immunol"},{"key":"ref154","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/carcin\/bgy177","article-title":"Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma","volume":"40","author":"Carminati","year":"2019","journal-title":"Carcinogenesis"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1158\/0008-5472.CAN-13-1816","article-title":"Inhibition of CSF1 receptor improves the anti-tumor efficacy of adoptive cell transfer immunotherapy","volume":"74","author":"Mok","year":"2014","journal-title":"Cancer Res"},{"key":"ref156","doi-asserted-by":"crossref","first-page":"e104230","DOI":"10.1371\/journal.pone.0104230","article-title":"P. Bachmann M, editor. Inhibition of CSF-1R supports T-cell mediated melanoma therapy","volume":"9","author":"Sluijter","year":"2014","journal-title":"PLoS One"},{"key":"ref157","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/pcmr.12845","article-title":"PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves BET inhibitor efficacy in melanoma","volume":"33","author":"Erkes","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref158","first-page":"TPS11618","article-title":"Phase 1\/2a study of double immune suppression blockade by combining a CSF1R inhibitor (Pexidartinib\/PLX3397) with an anti PD-1 antibody (Pembrolizumab) to treat advanced, solid tumors","volume":"34","author":"Patnaik","year":"2016","journal-title":"JCO Wolters Kluwer"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"22857","DOI":"10.18632\/oncotarget.3127","article-title":"Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma","volume":"6","author":"Tham","year":"2015","journal-title":"Oncotarget Impact J"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0026-895X(24)12222-5","article-title":"Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP\/ATP translocase by a nonhydrolyzable, adenine-containing metabolite","volume":"61","author":"Lehenkari","year":"2002","journal-title":"Mol Pharmacol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/sj.bjc.6603240","article-title":"Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach","volume":"95","author":"Zeisberger","year":"2006","journal-title":"Br J Cancer"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1158\/1535-7163.MCT-13-0315","article-title":"Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines","volume":"13","author":"Webster","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"ref164","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jconrel.2015.12.037","article-title":"A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: anti-angiogenic and anti-tumor effects","volume":"223","author":"Piaggio","year":"2016","journal-title":"J Control Release"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/sj.jid.5700827","article-title":"Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft","volume":"127","author":"Gazzaniga","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"931273","DOI":"10.3389\/fimmu.2022.931273","article-title":"Inside-Out of complement in cancer","volume":"13","author":"Kolev","year":"2022","journal-title":"Front Immunol"},{"key":"ref167","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.cell.2015.01.004","article-title":"PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer","volume":"160","author":"Bonavita","year":"2015","journal-title":"Cell"},{"key":"ref168","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.4049\/jimmunol.1600210","article-title":"The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses","volume":"196","author":"Nabizadeh","year":"2016","journal-title":"J Immunol"},{"key":"ref169","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/ijc.2910610520","article-title":"Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages","volume":"61","author":"Daemen","year":"1995","journal-title":"Int J Cancer"},{"key":"ref170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2017.10.024","article-title":"Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment","volume":"268","author":"Li","year":"2017","journal-title":"J Control Release"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"138971","DOI":"10.1016\/j.cej.2022.138971","article-title":"Boosting doxil-based chemoimmunotherapy via reprogramming tumor-associated macrophages","volume":"451","author":"Zhang","year":"2023","journal-title":"Chem Eng J"},{"key":"ref172","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1021\/mp500565q","volume":"11","author":"Niu","year":"2014","journal-title":"Mol Pharmaceut"},{"key":"ref173","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1084\/jem.20182124","article-title":"Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T-cell-mediated tumor regression","volume":"216","author":"Etzerodt","year":"2019","journal-title":"J Exp Med"},{"key":"ref174","doi-asserted-by":"crossref","first-page":"2127284","DOI":"10.1080\/2162402X.2022.2127284","article-title":"Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies","volume":"11","author":"Adams","year":"2022","journal-title":"Oncoimmunology"},{"key":"ref175","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1200\/JCO.2017.35.15_suppl.2523","article-title":"A phase I study of LY3022855, a colony-stimulating factor-1 receptor (CSF-1R) inhibitor, in patients (pts) with advanced solid tumors","volume":"35","author":"Dowlati","year":"2017","journal-title":"J Clin Oncol American Soc Clin Oncol"},{"key":"ref176","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s10637-021-01088-4","article-title":"A phase 1a\/1b trial of CSF-1R inhibitor LY3022855 in combination with durvalumab or tremelimumab in patients with advanced solid tumors","volume":"39","author":"Falchook","year":"2021","journal-title":"Invest New Drugs"},{"key":"ref177","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1158\/1535-7163.MCT-16-0157","article-title":"Macrophage susceptibility to Emactuzumab (RG7155) treatment","volume":"15","author":"Pradel","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"ref178","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/annonc\/mdz163","article-title":"Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced\/metastatic solid tumors reveals depletion of immunosuppressive M2-like macrophages","volume":"30","author":"Gomez-Roca","year":"2019","journal-title":"Ann Oncol"},{"key":"ref179","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41467-021-20893-2","article-title":"CAR-T-cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy","volume":"12","author":"Rodriguez-Garcia","year":"2021","journal-title":"Nat Commun"},{"key":"ref180","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41416-024-02715-6","article-title":"Clinical landscape of macrophage-reprogramming cancer immunotherapies","volume":"131","author":"Rannikko","year":"2024","journal-title":"Br J Cancer"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"e995559","DOI":"10.1080\/2162402X.2014.995559","volume":"4","author":"Banerjee","year":"2015","journal-title":"Oncoimmunology"},{"key":"ref182","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2567.2010.03357.x","article-title":"Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages","volume":"132","author":"Buhtoiarov","year":"2011","journal-title":"Immunology"},{"key":"ref183","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biomaterials.2016.09.034","article-title":"Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment","volume":"112","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"key":"ref184","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1038\/s41467-019-11911-5","article-title":"Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"key":"ref185","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.celrep.2016.04.084","article-title":"Reprogramming tumor-associated macrophages by antibody targeting inhibits cancer progression and metastasis","volume":"15","author":"Georgoudaki","year":"2016","journal-title":"Cell Rep"},{"key":"ref186","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/s41467-018-03225-9","article-title":"Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"ref187","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1186\/s12967-024-05763-x","article-title":"Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophages","volume":"22","author":"Fu","year":"2024","journal-title":"J Transl Med"},{"key":"ref188","doi-asserted-by":"crossref","first-page":"107628","DOI":"10.1016\/j.celrep.2020.107628","article-title":"Single-cell RNA sequencing reveals a dynamic stromal niche that supports tumor growth","volume":"31","author":"Davidson","year":"2020","journal-title":"Cell Rep Elsevier"},{"key":"ref189","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.2174\/0109298673282799231211113347","article-title":"Single-cell RNA sequencing analysis reveals the role of cancerassociated fibroblasts in skin melanoma","volume":"31","author":"Lian","year":"2024","journal-title":"Curr Med Chem"},{"key":"ref190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43856-022-00197-2","article-title":"Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanoma","volume":"2","author":"Xiao","year":"2022","journal-title":"Commun Med"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1158\/0008-5472.CAN-23-1418","article-title":"Integration of pan-cancer single-cell and spatial transcriptomics reveals stromal cell features and therapeutic targets in tumor microenvironment","volume":"84","author":"Du","year":"2024","journal-title":"Cancer Res"}],"container-title":["Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.techscience.cn\/files\/or\/2025\/TSP_OR-33-9\/OncolRes-33-09-64677\/OncolRes-33-64677.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:12:20Z","timestamp":1763345540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/or\/v33n9\/63630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":191,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.32604\/or.2025.064677","relation":{},"ISSN":["1555-3906"],"issn-type":[{"value":"1555-3906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}