{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:49:09Z","timestamp":1787906949657,"version":"build-2784847793"},"reference-count":138,"publisher":"Tech Science Press","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OR"],"published-print":{"date-parts":[[2025]]},"DOI":"10.32604\/or.2025.065222","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:19:02Z","timestamp":1753269542000},"page":"2243-2262","source":"Crossref","is-referenced-by-count":6,"title":["Polyphenols in Pancreatic Cancer Management: Exploring the Roles and Mechanisms of Resveratrol and Epigallocatechin"],"prefix":"10.32604","volume":"33","author":[{"given":"David A","family":"de la Garza-Kalife","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica L","family":"Loaiza-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Alhel\u00ed","family":"Hern\u00e1ndez-Tob\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Gonz\u00e1lez-Villarreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Francisco","family":"Islas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G","family":"Santoyo-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa N","family":"Garza-Trevi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Delgado-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17807","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41575-021-00431-7","article-title":"Harnessing metabolic dependencies in pancreatic cancers","volume":"18","author":"Encarnaci\u00f3n-Rosado","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.3390\/cancers14184351","article-title":"Targeting the metabolic rewiring in pancreatic cancer and its tumor microenvironment","volume":"14","author":"Yamamoto","year":"2022","journal-title":"Cancers"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"C229","DOI":"10.4103\/0973-1482.200744","article-title":"Helicobacter pylori infection and pancreatic cancer risk: a meta-analysis","volume":"12","author":"Guo","year":"2016","journal-title":"J Cancer Res Ther"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.3748\/wjg.v24.i43.4846","article-title":"Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes","volume":"24","author":"McGuigan","year":"2018","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.3390\/ijms22105138","article-title":"Coagulation signaling through par1 as a therapeutic target in pancreatic ductal adenocarcinoma","volume":"22","author":"Kothari","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1186\/s12885-023-11141-5","article-title":"Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial","volume":"23","author":"van Dam","year":"2023","journal-title":"BMC Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1533033820962117","DOI":"10.1177\/1533033820962117","article-title":"Pancreatic cancer: a review of risk factors, diagnosis, and treatment","volume":"19","author":"Zhao","year":"2020","journal-title":"Technol Cancer Res Treat"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.21873\/anticanres.14133","article-title":"Pathogenesis and treatment of pancreatic cancer related pain","volume":"40","author":"Lohse","year":"2020","journal-title":"Anticancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/nu9030243","article-title":"Nutritional and metabolic derangements in pancreatic cancer and pancreatic resection","volume":"9","author":"Gilliland","year":"2017","journal-title":"Nutrients"},{"key":"ref12","first-page":"40","article-title":"Abordaje de la desnutrici\u00f3n en pacientes hospitalizados con diabetes\/hiperglucemia y caquexia tumoral","volume":"39","author":"Burgos","year":"2022","journal-title":"Nutr Hosp"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3390\/cancers15092466","article-title":"Recent advances in pancreatic ductal adenocarcinoma: strategies to optimise the perioperative nutritional status in pancreatoduodenectomy patients","volume":"15","author":"Halle-Smith","year":"2023","journal-title":"Cancers"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/nu14214570","article-title":"Nutritional support in pancreatic diseases","volume":"14","author":"Ca\u00f1amares-Orb\u00eds","year":"2022","journal-title":"Nutrients"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.3390\/cancers15174265","article-title":"Advances in immunotherapeutics in pancreatic ductal adenocarcinoma","volume":"15","author":"Chouari","year":"2023","journal-title":"Cancers"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1089\/ars.2015.6437","volume":"24","author":"Benlloch","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13045-020-00958-3","article-title":"Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma","volume":"13","author":"Qian","year":"2020","journal-title":"J Hematol Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/cancers9050042","article-title":"KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 mutations in pancreatic cancer","volume":"9","author":"Cicenas","year":"2017","journal-title":"Cancers"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1053\/j.gastro.2022.03.056","article-title":"Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment","volume":"163","author":"Wood","year":"2022","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminoncol.2021.02.003","article-title":"KRAS mutation in pancreatic cancer","volume":"48","author":"Luo","year":"2021","journal-title":"Semin Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10555-021-09990-2","article-title":"Targeting KRAS in pancreatic cancer: new drugs on the horizon","volume":"40","author":"Bannoura","year":"2021","journal-title":"Cancer Metastasis Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrc.2016.66","article-title":"Pancreatic cancer biology and genetics from an evolutionary perspective","volume":"16","author":"Makohon-Moore","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"17450","DOI":"10.1073\/pnas.1901765116","article-title":"ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer","volume":"116","author":"Hashimoto","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3390\/ijms21103534","article-title":"SMAD4 and the TGF\u03b2 pathway in patients with pancreatic ductal adenocarcinoma","volume":"21","author":"Dardare","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7150\/ijbs.23230","article-title":"The role of TGF-\u03b2\/SMAD4 signaling in cancer","volume":"14","author":"Zhao","year":"2018","journal-title":"Int J Biol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-19-1353","article-title":"Fibroblast heterogeneity in the pancreatic tumor microenvironment","volume":"10","author":"Helms","year":"2020","journal-title":"Cancer Discov"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature19084","article-title":"Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion","volume":"536","author":"Sousa","year":"2016","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbrc.2010.11.040","article-title":"Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells","volume":"403","author":"Kikuta","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/boc.202000020","article-title":"Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia","volume":"112","author":"Estaras","year":"2020","journal-title":"Biol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.7150\/jca.38616","article-title":"Molecular mechanism of pancreatic stellate cells activation in chronic pancreatitis and pancreatic cancer","volume":"11","author":"Jin","year":"2020","journal-title":"J Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2012.11.037","article-title":"A starring role for stellate cells in the pancreatic cancer microenvironment","volume":"144","author":"Apte","year":"2013","journal-title":"Gastroenterology"},{"key":"ref32","first-page":"894","article-title":"Pancreatic cancer stem cells","volume":"5","author":"Zhu","year":"2015","journal-title":"Am J Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1002\/jcp.30229","article-title":"LDL cholesterol promotes the proliferation of prostate and pancreatic cancer cells by activating the STAT3 pathway","volume":"236","author":"Jung","year":"2021","journal-title":"J Cell Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumour microenvironment in pancreatic cancer\u2014clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1053\/j.gastro.2009.12.005","article-title":"Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia","volume":"138","author":"Strobel","year":"2010","journal-title":"Gastroenterology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3892\/ijo.2012.1597","article-title":"Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance","volume":"41","author":"Huang","year":"2012","journal-title":"Int J Oncol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"847760","DOI":"10.3389\/fendo.2022.847760","article-title":"Identification of the shared gene signatures and biological mechanism in type 2 diabetes and pancreatic cancer","volume":"13","author":"Hu","year":"2022","journal-title":"Front Endocrinol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/gutjnl-2021-325117","article-title":"Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer","volume":"72","author":"De Santis","year":"2023","journal-title":"Gut"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1038\/srep03230","article-title":"MTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions","volume":"3","author":"Matsubara","year":"2013","journal-title":"Sci Rep"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/gut.51.4.579","article-title":"Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells","volume":"51","author":"Jaster","year":"2002","journal-title":"Gut"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s13105-022-00899-0","article-title":"The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesis","volume":"79","author":"Barrera","year":"2023","journal-title":"J Physiol Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41419-022-04894-7","article-title":"Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS\/TGF\u03b2\/SMAD pathway","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1002\/jcp.29605","article-title":"Transforming growth factor-\u03b2 signaling, a potential mechanism associated with diabetes mellitus and pancreatic cancer?","volume":"235","author":"Ma","year":"2020","journal-title":"J Cell Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e2200750","DOI":"10.1002\/advs.202200750","article-title":"Aberrant cholesterol metabolism and Wnt\/\u03b2-catenin signaling coalesce via Frizzled5 in supporting cancer growth","volume":"9","author":"Zheng","year":"2022","journal-title":"Adv Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cac2.12360","article-title":"Lipid metabolism in pancreatic cancer: emerging roles and potential targets","volume":"42","author":"Yin","year":"2022","journal-title":"Cancer Commun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"578","DOI":"10.7150\/jca.21046","article-title":"Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis","volume":"9","author":"Jia","year":"2018","journal-title":"J Cancer"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41388-020-01518-2","article-title":"Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma","volume":"40","author":"Nimmakayala","year":"2021","journal-title":"Oncogene"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3390\/ijms21061913","article-title":"The p38 pathway: from biology to cancer therapy","volume":"21","author":"Mart\u00ednez-Lim\u00f3n","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/cancers15020498","article-title":"Biological and clinical impacts of glucose metabolism in pancreatic ductal adenocarcinoma","volume":"15","author":"Liu","year":"2023","journal-title":"Cancers"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3390\/cancers12051191","article-title":"The role of hyperglycemia in endometrial cancer pathogenesis","volume":"12","author":"Byrne","year":"2020","journal-title":"Cancers"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.redox.2018.09.025","article-title":"New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis","volume":"20","author":"Yuan","year":"2019","journal-title":"Redox Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1038650","DOI":"10.3389\/fimmu.2022.1038650","article-title":"Glucose metabolism and tumour microenvironment in pancreatic cancer: a key link in cancer progression","volume":"13","author":"Dong","year":"2022","journal-title":"Front Immunol"},{"key":"ref53","first-page":"e26288","article-title":"The role of type 2 diabetes in pancreatic cancer","volume":"14","author":"George","year":"2022","journal-title":"Cureus"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e20200388","DOI":"10.1084\/jem.20200388","article-title":"Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer","volume":"217","author":"Recouvreux","year":"2020","journal-title":"J Exp Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12943-020-01169-7","article-title":"Metabolism of pancreatic cancer: paving the way to better anticancer strategies","volume":"19","author":"Qin","year":"2020","journal-title":"Mol Cancer"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.3390\/ijerph20032403","article-title":"Adherence to mediterranean diet and risk of pancreatic cancer: systematic review and meta-analysis","volume":"20","author":"Nucci","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3892\/or.2021.8060","article-title":"Role of SIRT1\/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells","volume":"45","author":"Wang","year":"2021","journal-title":"Oncol Rep"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.3390\/molecules25143146","article-title":"Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer","volume":"25","author":"Almatrood","year":"2020","journal-title":"Molecules"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9060547","article-title":"Polyphenols as possible agents for pancreatic diseases","volume":"9","author":"Ga\u0161i\u0107","year":"2020","journal-title":"Antioxidants"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/hsr2.2085","article-title":"A comprehensive review on phytochemicals in the treatment and prevention of pancreatic cancer: focusing on their mechanism of action","volume":"7","author":"Arnab","year":"2024","journal-title":"Health Sci Rep"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1021\/acsomega.3c05861","article-title":"Phytochemicals in pancreatic cancer treatment: a machine learning study","volume":"9","author":"Genc","year":"2024","journal-title":"ACS Omega"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1051952","DOI":"10.3389\/fphar.2022.1051952","article-title":"The therapeutic potential of natural products for treating pancreatic cancer","volume":"13","author":"He","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e2246","DOI":"10.1038\/cddis.2016.157","article-title":"Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy","volume":"7","author":"Fan","year":"2016","journal-title":"Cell Death Dis"},{"key":"ref64","first-page":"13","article-title":"Health benefits of resveratrol administration","volume":"66","author":"Galiniak","year":"2019","journal-title":"Acta Biochim Pol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/nyas.12837","article-title":"Resveratrol in the treatment of pancreatic cancer","volume":"1348","author":"Xu","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and its effects on the vascular system","volume":"20","author":"Breuss","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"100342","DOI":"10.4251\/wjgo.v17.i3.100342","article-title":"Resveratrol and pancreatic cancers: questions and future perspectives","volume":"17","author":"Sukocheva","year":"2025","journal-title":"World J Gastrointest Oncol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"35448","DOI":"10.18632\/oncotarget.26234","article-title":"Naturally occurring compounds as pancreatic cancer therapeutics","volume":"9","author":"Lohse","year":"2018","journal-title":"Oncotarget"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"110116","DOI":"10.1016\/j.biopha.2020.110116","article-title":"Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NF\u03baB activation","volume":"127","author":"Qian","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"111268","DOI":"10.1016\/j.biopha.2021.111268","article-title":"Resveratrol supplementation and acute pancreatitis: a comprehensive review","volume":"137","author":"Agah","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"50","DOI":"10.18332\/tid\/95159","article-title":"Effects of a natural polyphenol on nicotine-induced pancreatic cancer cell proliferation","volume":"16","author":"Chowdhury","year":"2018","journal-title":"Tob Induc Dis"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"963689720929987","DOI":"10.1177\/0963689720929987","article-title":"Resveratrol ameliorates the malignant progression of pancreatic cancer by inhibiting hypoxia-induced pancreatic stellate cell activation","volume":"29","author":"Xiao","year":"2020","journal-title":"Cell Transplant"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.apsb.2019.11.008","article-title":"Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer","volume":"10","author":"Ramakrishnan","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.20964\/2017.07.06","article-title":"Antioxidant and antiradical properties of green tea extract compounds","volume":"12","author":"Masek","year":"2017","journal-title":"Int J Electrochem Sci"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/beverages3010017","article-title":"Green tea and its extracts in cancer prevention and treatment","volume":"3","author":"Schulze","year":"2017","journal-title":"Beverages"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3390\/ijms21051744","article-title":"Beneficial properties of green tea catechins","volume":"21","author":"Musial","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"108782","DOI":"10.1016\/j.foodres.2019.108782","article-title":"Kombuchas from green and black teas have different phenolic profile, which impacts their antioxidant capacities, antibacterial and antiproliferative activities","volume":"128","author":"Cardoso","year":"2020","journal-title":"Food Res Intern"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1080\/10408398.2019.1661827","article-title":"Targeting NF-\u03baB signaling pathway in cancer by dietary polyphenols","volume":"60","author":"Khan","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.semcancer.2020.11.018","article-title":"Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator","volume":"83","author":"Li","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/nu8050307","article-title":"Epigallocatechin gallate nanodelivery systems for cancer therapy","volume":"8","author":"Granja","year":"2016","journal-title":"Nutrients"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s43556-024-00240-9","article-title":"Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies","volume":"5","author":"Alam","year":"2024","journal-title":"Mol Biomed"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3390\/molecules30030654","article-title":"Epigallocatechin gallate (EGCG): pharmacological properties, biological activities and therapeutic potential","volume":"30","author":"Capasso","year":"2025","journal-title":"Molecules"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1078642","DOI":"10.3389\/fnut.2022.1078642","volume":"9","author":"Suhail","year":"2023","journal-title":"Front Nutr"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2445774","DOI":"10.1080\/07853890.2024.2445774","article-title":"Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy","volume":"57","author":"Sun","year":"2025","journal-title":"Ann Med"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"116920","DOI":"10.1016\/j.bmc.2022.116920","article-title":"Targeting the interaction of \u03b2-catenin and TCF\/LEF transcription factors to inhibit oncogenic Wnt signaling","volume":"70","author":"Koelman","year":"2022","journal-title":"Bioorg Med Chem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ijc.26323","article-title":"Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics","volume":"131","author":"Tang","year":"2012","journal-title":"Int J Cancer"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1142\/S0192415X20500482","article-title":"Intra-pancreatic insulin nourishes cancer cells: do insulin-receptor antagonists such as PGG and EGCG play a role?","volume":"48","author":"Hu","year":"2020","journal-title":"Am J Chin Med"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"e2248","DOI":"10.31661\/gmj.v11i.2248","article-title":"Effect of sodium butyrate and epigallocatechin-3-gallate on the genes expression of intrinsic apoptotic pathway on PA-TU-8902, CFPAC-1, and CAPAN-1 human pancreatic cancer cell lines","volume":"11","author":"Kavoosi","year":"2022","journal-title":"Galen Medical J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1471-2407-10-238","article-title":"Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R\/Wnt and activation of p53 signaling pathways","volume":"10","author":"Vanamala","year":"2010","journal-title":"BMC Cancer"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"e97016","DOI":"10.1371\/journal.pone.0097016","article-title":"Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis","volume":"9","author":"Subramani","year":"2014","journal-title":"PLoS One"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1346958","DOI":"10.1155\/2018\/1346958","article-title":"Resveratrol inhibits ROS-promoted activation and glycolysis of pancreatic stellate cells via suppression of miR-21","volume":"2018","author":"Yan","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fonc.2020.01038","article-title":"NAF-1 inhibition by resveratrol suppresses cancer stem cell-like properties and the invasion of pancreatic cancer","volume":"10","author":"Qin","year":"2020","journal-title":"Front Oncol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"112126","DOI":"10.1016\/j.yexcr.2020.112126","article-title":"Resveratrol binds and inhibits transcription factor HIF-1\u03b1 in pancreatic cancer","volume":"394","author":"Srivani","year":"2020","journal-title":"Exp Cell Res"},{"key":"ref94","first-page":"1051","article-title":"Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB-2-HIF-1\u03b1 axis","volume":"41","author":"Ma","year":"2019","journal-title":"Oncol Rep"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3892\/ijo.2016.3559","article-title":"Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways","volume":"49","author":"Cao","year":"2016","journal-title":"Int J Oncol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3390\/pharmaceutics13111871","article-title":"Comparative study on inhibition of pancreatic cancer cells by resveratrol gold nanoparticles and a resveratrol nanoemulsion prepared from grape skin","volume":"13","author":"Inbaraj","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.3390\/molecules26216560","article-title":"Effect of resveratrol treatment on human pancreatic cancer cells through alterations of bcl-2 family members","volume":"26","author":"Ratajczak","year":"2021","journal-title":"Molecules"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.3390\/molecules26216741","article-title":"Chloroquine potentiates the anticancer effect of pterostilbene on pancreatic cancer by inhibiting autophagy and downregulating the rage\/stat3 pathway","volume":"26","author":"Chen","year":"2021","journal-title":"Molecules"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"31672","DOI":"10.1038\/srep31672","volume":"6","author":"Duan","year":"2016","journal-title":"Sci Rep"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3390\/ijms24031977","article-title":"Resveratrol derivative exhibits marked antiproliferative actions, affecting stemness in pancreatic cancer cells","volume":"24","author":"Florio","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref101","first-page":"1306","article-title":"Triacetyl resveratrol upregulates miRNA-200 and suppresses the Shh pathway in pancreatic cancer: a potential therapeutic agent","volume":"54","author":"Fu","year":"2019","journal-title":"Int J Oncol"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"Humphries B, Yang C. Oncotarget 6472 [Internet]. The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy. [cited 2025 May 15]. Available from: www.impactjournals.com\/oncotarget.","DOI":"10.18632\/oncotarget.3052"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/nu14112306","article-title":"Piceatannol, a dietary polyphenol, alleviates adipose tissue loss in pre-clinical model of cancer-associated cachexia via lipolysis inhibition","volume":"14","author":"Kershaw","year":"2022","journal-title":"Nutrients"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1080\/01635581.2021.1933097","article-title":"Combinations of phytochemicals more efficiently than single components activate Nrf2 and induce the expression of antioxidant enzymes in pancreatic cancer cells","volume":"74","author":"Cykowiak","year":"2022","journal-title":"Nutr Cancer"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2017.01.002","article-title":"Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model","volume":"390","author":"Vendrely","year":"2017","journal-title":"Cancer Lett"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3892\/or.2016.4930","article-title":"Classical and atypical resistance of cancer cells as a target for resveratrol","volume":"36","author":"Borska","year":"2016","journal-title":"Oncol Rep"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpharm.2018.09.016","article-title":"Comparative study of the therapeutic effect of Doxorubicin and Resveratrol combination on 2D and 3D (spheroids) cell culture models","volume":"551","author":"Barros","year":"2018","journal-title":"Int J Pharm"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00432-020-03384-7","article-title":"Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B","volume":"147","author":"Yang","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"e12514","DOI":"10.1111\/cpr.12514","article-title":"Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1","volume":"52","author":"Zhou","year":"2019","journal-title":"Cell Prolif"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"9482018","DOI":"10.1155\/2018\/9482018","article-title":"Resveratrol-induced downregulation of NAF-1 enhances the sensitivity of pancreatic cancer cells to gemcitabine via the ROS\/Nrf2 signaling pathways","volume":"2018","author":"Cheng","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/nu8100546","article-title":"YAP inhibition by resveratrol via activation of AMPK enhances the sensitivity of pancreatic cancer cells to gemcitabine","volume":"8","author":"Jiang","year":"2016","journal-title":"Nutrients"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/biom10050709","article-title":"Pterostilbene enhances cytotoxicity and chemosensitivity in human pancreatic cancer cells","volume":"10","author":"Hsu","year":"2020","journal-title":"Biomolecules"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1038\/s41388-018-0584-6","volume":"38","author":"Chen","year":"2019","journal-title":"Oncogene"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12935-024-03219-2","article-title":"Fabrication of magnetic niosomal platform for delivery of resveratrol: potential anticancer activity against human pancreatic cancer Capan-1 cell","volume":"24","author":"Firouzi Amandi","year":"2024","journal-title":"Cancer Cell Int"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"e37942","DOI":"10.1371\/journal.pone.0037942","article-title":"Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor","volume":"7","author":"Fujimura","year":"2012","journal-title":"PLoS One"},{"key":"ref116","first-page":"787","article-title":"67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis","volume":"123","author":"Kumazoe","year":"2013","journal-title":"J Clin Investig"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.3390\/molecules27165130","article-title":"67-kDa laminin receptor-mediated cellular sensing system of green tea polyphenol EGCG and functional food pairing","volume":"27","author":"Fujimura","year":"2022","journal-title":"Molecules"},{"key":"ref118","first-page":"281","article-title":"Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death","volume":"34","author":"Basu","year":"2009","journal-title":"Int J Oncol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.2741\/2446","article-title":"Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer","volume":"12","author":"Shankar","year":"2007","journal-title":"Front Biosci"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1349-7006.2011.01870.x","article-title":"Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells","volume":"102","author":"K\u00fcrbitz","year":"2011","journal-title":"Cancer Sci"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3892\/ijo.2014.2539","article-title":"Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition","volume":"45","author":"Appari","year":"2014","journal-title":"Int J Oncol"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-012-1448-y","article-title":"EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1\/FOXO3a and neuropilin","volume":"372","author":"Shankar","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11306-014-0672-8","article-title":"Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells","volume":"11","author":"Lu","year":"2015","journal-title":"Metabolomics"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3892\/ijo.2012.1686","article-title":"(-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC-1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity","volume":"42","author":"Kim","year":"2013","journal-title":"Int J Oncol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.3390\/nu11081856","article-title":"Epigallocatechin-3-gallate (EGCG) suppresses pancreatic cancer cell growth, invasion, and migration partly through the inhibition of akt pathway and epithelial-mesenchymal transition: enhanced efficacy when combined with gemcitabine","volume":"11","author":"Wei","year":"2019","journal-title":"Nutrients"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0215(19970127)70:3<255::AID-IJC1>3.0.CO;2-W","article-title":"Green tea consumption and the risk of pancreatic and colorectal cancers","volume":"70","author":"Ji","year":"1997","journal-title":"Int J Cancer"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.1016\/j.canep.2012.08.004","article-title":"Green tea drinking and risk of pancreatic cancer: a large-scale, population-based case-control study in urban Shanghai","volume":"36","author":"Wang","year":"2012","journal-title":"Cancer Epidemiol"},{"key":"ref128","first-page":"290516","article-title":"Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor","volume":"2010","author":"Sato","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1021\/mp900037p","article-title":"(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line mia paca-2","volume":"6","author":"Li","year":"2009","journal-title":"Mol Pharm"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.bcp.2011.07.063","article-title":"EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells","volume":"82","author":"Hoffmann","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MPA.0000000000000175","article-title":"Potential new pharmacological agents derived from medicinal plants for the treatment of pancreatic cancer","volume":"44","author":"Azimi","year":"2015","journal-title":"Pancreas"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2741\/2691","article-title":"EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer","volume":"13","author":"Shankar","year":"2008","journal-title":"Front Biosci"},{"key":"ref133","first-page":"286","article-title":"A multi-institute case-control study on the risk factors of developing pancreatic cancer","volume":"22","author":"Mizuno","year":"1992","journal-title":"Jpn J Clin Oncol"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.3390\/nu6114640","article-title":"Green tea consumption and risk of pancreatic cancer: a meta-analysis","volume":"6","author":"Zeng","year":"2014","journal-title":"Nutrients"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13027-015-0016-y","article-title":"Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth","volume":"10","author":"Bimonte","year":"2015","journal-title":"Infect Agent Cancer"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/cancers11101496","article-title":"Targeting glycolysis with epigallocatechin-3-gallate enhances the efficacy of chemotherapeutics in pancreatic cancer cells and xenografts","volume":"11","author":"Wei","year":"2019","journal-title":"Cancers"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"108546","DOI":"10.1016\/j.abb.2020.108546","article-title":"EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines","volume":"692","author":"Wei","year":"2020","journal-title":"Arch Biochem Biophys"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/pharmaceutics14030491","article-title":"Nanocarriers based on gold nanoparticles for epigallocatechin gallate delivery in cancer cells","volume":"14","author":"Cunha","year":"2022","journal-title":"Pharmaceutics"}],"container-title":["Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.techscience.cn\/files\/or\/2025\/TSP_OR-33-9\/OncolRes-33-09-65222\/OncolRes-33-65222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:13:01Z","timestamp":1763345581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/or\/v33n9\/63635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":138,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.32604\/or.2025.065222","relation":{},"ISSN":["1555-3906"],"issn-type":[{"value":"1555-3906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}