{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:48:36Z","timestamp":1771102116199,"version":"3.50.1"},"reference-count":40,"publisher":"Acta Naturae Ltd","issue":"4","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Naturae"],"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF) is known to be involved in the pathogenesis of Alzheimers disease (AD). However, the pharmacological use of full-length neurotrophin is limited, because of its macromolecular protein nature. A dimeric dipeptide mimetic of the BDNF loop 1, bis-(N-monosuccinyl-L-methionyl-L-serine) heptamethylene diamide (GSB-214), was designed at the Zakusov Research Institute of Pharmacology. GSB-214 activates TrkB, PI3K\/AKT, and PLC-1 in vitro. GSB-214 exhibited a neuroprotective activity during middle cerebral artery occlusion in rats when administered intraperitoneally (i.p.) at a dose of 0.1 mg\/kg and improved memory in the novel object recognition test (0.1 and 1.0 mg\/kg, i.p.). In the present study, we investigated the effects of GSB-214 on memory in the scopolamine- and steptozotocin-induced AD models, with reference to activation of TrkB receptors. AD was modeled in rats using a chronic i.p. scopolamine injection or a single streptozotocin injection into the cerebral ventricles. GSB-214 was administered within 10 days after the exposure to scopolamine at doses of 0.05, 0.1, and 1 mg\/kg (i.p.) or within 14 days after the exposure to streptozotocin at a dose of 0.1 mg\/kg (i.p.). The effect of the dipeptide was evaluated in the novel object recognition test; K252A, a selective inhibitor of tyrosine kinase receptors, was used to reveal a dependence between the mnemotropic action and Trk receptors. GSB-214 at doses of 0.05 and 0.1 mg\/kg statistically significantly prevented scopolamine-induced long-term memory impairment, while not affecting short-term memory. In the streptozotocin-induced model, GSB-214 completely eliminated the impairment of short-term memory. No mnemotropic effect of GSB-214 was registered when Trk receptors were inhibited by K252A.<\/jats:p>","DOI":"10.32607\/actanaturae.11755","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:21:44Z","timestamp":1674260504000},"page":"94-100","source":"Crossref","is-referenced-by-count":7,"title":["A Low-Molecular-Weight BDNF Mimetic, Dipeptide GSB-214, Prevents Memory Impairment in Rat Models of Alzheimer\u2019s Disease"],"prefix":"10.32607","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-8915","authenticated-orcid":false,"given":"Polina Yu.","family":"Povarnina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna A.","family":"Volkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga N.","family":"Vorontsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A.","family":"Kamensky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-4474","authenticated-orcid":false,"given":"Tatiana A.","family":"Gudasheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4482-9331","authenticated-orcid":false,"given":"Sergey B.","family":"Seredenin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17808","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s disease facts and figures \/\/ Alzheimer\u2019s Dementia. 2019. 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