{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:26:47Z","timestamp":1762410407871,"version":"3.33.0"},"reference-count":76,"publisher":"Acta Naturae Ltd","issue":"4","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Naturae"],"abstract":"<jats:p>The gradually increasing age of the world population implies that the prevalence of neurodegenerative diseases also continues to rise. These diseases are characterized by a progressive loss of cognitive and motor functions. Parkinson\u2019s disease, which involves the gradual death of specialized neural tissue, is a striking example of a neurodegenerative process. The pathomorphological analysis shows that chronic cerebral ischemia is accompanied by extensive complex neurodegeneration; parkinsonism is its clinical manifestation in 20\u201330% of cases. Although Parkinson\u2019s disease and vascular parkinsonism are similar, these two pathologies have fundamentally different etiopathogeneses. But their set of differential diagnosis traits is confined to some features of the neurological status. There currently exist no diagnostic markers for individual neurodegenerative pathologies or the neurodegeneration phenomenon in general. Metabolomic profiling can be a promising means for finding a unique \u201cfingerprint\u201d of the disease. Identifying the biomarkers of various neurodegenerative diseases will help shorten the time to the diagnosis, forecast the course of the disease, and personalize the therapeutic approach. This review summarizes and compares the current concepts of metabolomics research into Parkinson\u2019s disease and vascular parkinsonism, as well as the respective animal models.<\/jats:p>","DOI":"10.32607\/actanaturae.27511","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T01:45:47Z","timestamp":1737596747000},"page":"27-37","source":"Crossref","is-referenced-by-count":2,"title":["The Characteristics of the Metabolomic Profile in Patients with Parkinson\u2019s Disease and Vascular Parkinsonism"],"prefix":"10.32607","volume":"16","author":[{"given":"E. V.","family":"Predtechenskaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Rogachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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