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\u043b\u0438\u043c\u0444\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u043e\u0433\u043e \u043b\u0435\u0439\u043a\u043e\u0437\u0430 (B-\u041e\u041b\u041b), \u043e\u0431\u043d\u0430\u0440\u0443\u0436\u0438\u043b\u0438 \u0445\u0440\u043e\u043c\u043e\u0441\u043e\u043c\u043d\u0443\u044e \u0442\u0440\u0430\u043d\u0441\u043b\u043e\u043a\u0430\u0446\u0438\u044e t(9;22)(q34;q11), \u0438\u043b\u0438 \u0444\u0438\u043b\u0430\u0434\u0435\u043b\u044c\u0444\u0438\u0439\u0441\u043a\u0443\u044e (Ph) \u0445\u0440\u043e\u043c\u043e\u0441\u043e\u043c\u0443 \u0438 \u043c\u0435\u043d\u0435\u0435 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u044b\u0439 \u0432\u0430\u0440\u0438\u0430\u043d\u0442 \u0445\u0438\u043c\u0435\u0440\u043d\u043e\u0433\u043e \u043e\u043d\u043a\u043e\u0433\u0435\u043d\u0430 BCR::ABL\/p210. \u041f\u0440\u0438 \u044d\u0442\u043e\u043c \u0432 \u0434\u0435\u0431\u044e\u0442\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0441 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u0431\u043b\u0430\u0441\u0442\u043d\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a (77.6%) \u0438 \u043b\u0435\u0439\u043a\u043e\u0446\u0438\u0442\u043e\u0432 (48\u00d7109\/\u043b) \u043a\u0430\u043a\u0438\u0445-\u043b\u0438\u0431\u043e \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043c\u0443\u0442\u0430\u0446\u0438\u0439 \u0432 \u0433\u0435\u043d\u0435 BCR::ABL, \u0432\u043a\u043b\u044e\u0447\u0430\u044f \u0442\u043e\u0447\u0435\u0447\u043d\u044b\u0435 \u043c\u0443\u0442\u0430\u0446\u0438\u0438, \u0432\u0441\u0442\u0430\u0432\u043a\u0438 \u0438\u043b\u0438 \u0434\u0435\u043b\u0435\u0446\u0438\u0438, \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u043e \u043d\u0435 \u0431\u044b\u043b\u043e. \u041f\u043e\u0441\u043b\u0435 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u00abPh+ALL-2012m\u00bb \u0441 \u0434\u043e\u0431\u0430\u0432\u043b\u0435\u043d\u0438\u0435\u043c \u0438\u043c\u0430\u0442\u0438\u043d\u0438\u0431\u0430 (600 \u043c\u0433) \u0438 \u0434\u0432\u0443\u0445 \u0444\u0430\u0437 \u043a\u043e\u043d\u0441\u043e\u043b\u0438\u0434\u0430\u0446\u0438\u0438 \u043e\u0442\u043c\u0435\u0447\u0430\u043b\u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043f\u043e\u043b\u043d\u043e\u0439 \u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0440\u0435\u043c\u0438\u0441\u0441\u0438\u0438 \u0438 \u0433\u043b\u0443\u0431\u043e\u043a\u043e\u0433\u043e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u043e\u0442\u0432\u0435\u0442\u0430. \u041e\u0434\u043d\u0430\u043a\u043e \u0441\u043f\u0443\u0441\u0442\u044f 6 \u043c\u0435\u0441\u044f\u0446\u0435\u0432 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0440\u0430\u0437\u0432\u0438\u043b\u0441\u044f \u0440\u0435\u0446\u0438\u0434\u0438\u0432 (\u0431\u043b\u0430\u0441\u0442\u044b: 15%, BCR::ABL\/p210: 105%). \u0427\u0435\u0440\u0435\u0437 3 \u043d\u0435\u0434\u0435\u043b\u0438 \u043f\u043e\u0441\u043b\u0435 \u043d\u0430\u0447\u0430\u043b\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0434\u0430\u0437\u0430\u0442\u0438\u043d\u0438\u0431\u043e\u043c (100 \u043c\u0433) \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0431\u043b\u0430\u0441\u0442\u043e\u0432 \u0443\u043c\u0435\u043d\u044c\u0448\u0438\u043b\u043e\u0441\u044c \u0434\u043e 4.8%, \u0430 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 BCR::ABL\/p210 \u0441\u043d\u0438\u0437\u0438\u043b\u0441\u044f \u0434\u043e 11.8%. \u0421\u0435\u043a\u0432\u0435\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u043e \u0421\u044d\u043d\u0433\u0435\u0440\u0443 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\u0437\u0430\u043c\u0435\u0449\u0435\u043d \u043d\u0430 \u0447\u0435\u0442\u044b\u0440\u0435 \u043d\u043e\u0432\u044b\u0445 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u043d\u044b\u0445 \u043e\u0441\u0442\u0430\u0442\u043a\u0430: K294SPSQ. \u041f\u043e\u0441\u043b\u0435 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0431\u043e\u0437\u0443\u0442\u0438\u043d\u0438\u0431\u043e\u043c \u0438 \u0438\u043d\u043e\u0442\u0443\u0437\u0443\u043c\u0430\u0431\u043e\u043c \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u043e\u0441\u044c \u0438\u0441\u0447\u0435\u0437\u043d\u043e\u0432\u0435\u043d\u0438\u0435 \u043e\u0434\u043d\u043e\u0433\u043e \u043b\u0435\u0439\u043a\u043e\u0437\u043d\u043e\u0433\u043e \u043a\u043b\u043e\u043d\u0430 \u0441 \u043c\u0443\u0442\u0430\u0446\u0438\u0435\u0439 F317L, \u043e\u0434\u043d\u0430\u043a\u043e \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u043b\u043e\u0441\u044c \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0434\u0440\u0443\u0433\u043e\u0433\u043e \u043a\u043b\u043e\u043d\u0430, \u043d\u0435\u0441\u0443\u0449\u0435\u0433\u043e \u0432\u0441\u0442\u0430\u0432\u043a\u0443 \u0438\u0437 9 \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u043e\u0432. \u0421\u043c\u0435\u043d\u0430 \u043a\u0443\u0440\u0441\u0430 \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043d\u0430 \u043f\u043e\u043d\u0430\u0442\u0438\u043d\u0438\u0431+\u0431\u043b\u0438\u043d\u0430\u0442\u0443\u043c\u043e\u043c\u0430\u0431 \u043e\u043a\u0430\u0437\u0430\u043b\u0430\u0441\u044c \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0439. \u042d\u0442\u043e \u043f\u0440\u0438\u0432\u0435\u043b\u043e \u043a \u0438\u0441\u0447\u0435\u0437\u043d\u043e\u0432\u0435\u043d\u0438\u044e \u0438\u043d\u0441\u0435\u0440\u0446\u0438\u0438. \u041f\u043e\u0441\u043b\u0435 \u0430\u043b\u043b\u043e\u0433\u0435\u043d\u043d\u043e\u0439 \u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0438\u0438 \u0433\u0435\u043c\u043e\u043f\u043e\u044d\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a (\u0430\u043b\u043b\u043e-\u0422\u0413\u0421\u041a) \u043e\u0442 \u043d\u0435\u0440\u043e\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e HLA-\u0441\u043e\u0432\u043c\u0435\u0441\u0442\u0438\u043c\u043e\u0433\u043e \u0434\u043e\u043d\u043e\u0440\u0430 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u043e\u0441\u044c \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043f\u043e\u043b\u043d\u043e\u0439 \u043a\u043b\u0438\u043d\u0438\u043a\u043e-\u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0440\u0435\u043c\u0438\u0441\u0441\u0438\u0438 \u0438 \u043f\u043e\u043b\u043d\u043e\u0433\u043e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u043e\u0442\u0432\u0435\u0442\u0430. \u041c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u043c\u0438\u043d\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0439 \u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0441\u043f\u0443\u0441\u0442\u044f 6 \u043c\u0435\u0441\u044f\u0446\u0435\u0432 \u043f\u043e\u0441\u043b\u0435 \u0430\u043b\u043b\u043e-\u0422\u0413\u0421\u041a \u043f\u043e\u043a\u0430\u0437\u0430\u043b \u0441\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u0440\u0435\u043c\u0438\u0441\u0441\u0438\u0438.<\/jats:p>","DOI":"10.32607\/actanaturae.27539","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T20:52:45Z","timestamp":1753476765000},"page":"52-57","source":"Crossref","is-referenced-by-count":0,"title":["\u0412\u043e\u0437\u043d\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0438\u0435 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