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In this review, we discuss the basic principles of ferroptosis in cancer. Considerable attention is paid to the formation of an immunosuppressive tumor microenvironment. The main focus is centered on the involvement of the excessive, chronic production of pro-inflammatory cytokines in ferroptosis resistance development in tumors.<\/jats:p>","DOI":"10.32607\/actanaturae.27547","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:47:34Z","timestamp":1766483254000},"page":"4-10","source":"Crossref","is-referenced-by-count":4,"title":["Pro-inflammatory cytokines, ferroptosis, and cancer"],"prefix":"10.32607","volume":"17","author":[{"given":"A. A.","family":"Vartanian","sequence":"additional","affiliation":[{"name":"N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S.","family":"Kosorukov","sequence":"additional","affiliation":[{"name":"N.N. 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