{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:40:50Z","timestamp":1760740850883,"version":"build-2065373602"},"reference-count":12,"publisher":"Acta Naturae Ltd","issue":"3","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Naturae"],"abstract":"<jats:p>Widespread environmental contamination with polychlorinated biphenyls (PCBs) leads to serious health problems for humans and animals. Our main focus should be on studying the negative effects of exposure to medium- and highly chlorinated PCBs in the human body. There is limited information on the impact of low-chlorinated biphenyls containing 1\u20132 substituents per molecule on the functions of mammalian organs and systems. Under natural conditions, PCBs can undergo bacterial degradation; the resulting compounds belong to a group of secondary pollutants and are considered hazardous to the environment. Because of limited research, the question regarding the impact of mono-substituted chlorobiphenyl congeners, as well as the products of their biotransformation, remains open. In the presented work, the effects of ortho- and meta-substituted monochlorinated biphenyls on the functions of immune system cells and the morphofunctional state of the liver of mammals in vivo are revealed for the first time. PCB 1 and PCB 2 were found to suppress humoral immunity and induce a productive inflammatory response, as well as widespread protein dystrophy with necrotic foci in the liver. The products of a aerobic bacterial transformation of PCB 1 and PCB 2 were shown to not have a negative effect on the mammalian immune system but proved toxic to hepatocytes, although to a lesser extent than the original chlorobiphenyls.<\/jats:p>","DOI":"10.32607\/actanaturae.27596","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:34:18Z","timestamp":1760441658000},"page":"40-43","source":"Crossref","is-referenced-by-count":0,"title":["&lt;i&gt;Ortho&lt;\/i&gt;- and &lt;i&gt;meta&lt;\/i&gt;-monochlorinated biphenyls suppress humoral immunity and exert toxic effects on mouse liver cells"],"prefix":"10.32607","volume":"17","author":[{"given":"D. O.","family":"Egorova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. V.","family":"Gein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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