{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:43:02Z","timestamp":1777945382367,"version":"3.51.4"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andes pediatr"],"abstract":"<jats:p>La hipoton\u00eda del reci\u00e9n nacido y del lactante es un desaf\u00edo diagn\u00f3stico frecuente en la pr\u00e1ctica pedi\u00e1trica. Se define como la disminuci\u00f3n de la resistencia al movimiento pasivo. El s\u00edndrome hipot\u00f3nico es un diagn\u00f3stico de trabajo y se debe identificar su causa para determinar morbilidades asociadas, pron\u00f3stico y manejo. R\u00e1pidos avances en bioinform\u00e1tica y pruebas gen\u00e9ticas moleculares permiten obtener diagn\u00f3sticos de precisi\u00f3n tempranamente en el proceso diagn\u00f3stico, por lo cual se hace necesario realizar una revisi\u00f3n actualizada en este tema. El objetivo de esta actualizaci\u00f3n es describir la aproximaci\u00f3n diagn\u00f3stica al s\u00edndrome hipot\u00f3nico y sus principales etiolog\u00edas. Se realiz\u00f3 una revisi\u00f3n de la literatura en PubMed y Scielo, incluyendo art\u00edculos relevantes en ingl\u00e9s y espa\u00f1ol publicados en los \u00faltimos 15 a\u00f1os. Se enfatiza el valor del examen e historia cl\u00ednica en la localizaci\u00f3n de la causa de la hipoton\u00eda (central o perif\u00e9rica) como primer paso hacia el diagn\u00f3stico etiol\u00f3gico. Enfermedades sist\u00e9micas como encefalopat\u00eda hip\u00f3xico-isqu\u00e9mica, sepsis, insuficiencia card\u00edaca, alteraciones metab\u00f3licas y de electrolitos plasm\u00e1ticos son a\u00fan causas comunes de hipoton\u00eda central. La hipoton\u00eda perif\u00e9rica implica trastornos del asta anterior de la m\u00e9dula espinal, nervio perif\u00e9rico, uni\u00f3n neuromuscular o m\u00fasculo, de origen hereditario o adquirido. El uso de im\u00e1genes del sistema nervioso central y m\u00fasculo, paneles gen\u00e9ticos y exoma, constituyen los m\u00e1s recientes aportes al diagn\u00f3stico del s\u00edndrome hipot\u00f3nico. Este art\u00edculo propone un enfrentamiento inicial basado en los principales elementos cl\u00ednicos que orienten a un determinado diagn\u00f3stico. La terapia es de soporte, excepto por algunas condiciones que tienen tratamiento espec\u00edfico.<\/jats:p>","DOI":"10.32641\/andespediatr.v93i4.4050","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T16:49:02Z","timestamp":1660841342000},"page":"458-469","source":"Crossref","is-referenced-by-count":1,"title":["S\u00edndrome hipot\u00f3nico del reci\u00e9n nacido y lactante"],"prefix":"10.32641","volume":"93","author":[{"given":"Daniela","family":"Alarc\u00f3n Ben\u00edtez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los Angeles","family":"Beyt\u00eda Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal G.","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Nu\u00f1ez Far\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"L\u00f3pez Bohner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Avila-Smirnow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2022,8,18]]},"container-title":["Andes Pediatrica"],"original-title":[],"link":[{"URL":"https:\/\/andespediatrica.cl\/index.php\/rchped\/article\/download\/4050\/4103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/andespediatrica.cl\/index.php\/rchped\/article\/download\/4050\/4103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:38:53Z","timestamp":1777721933000},"score":1,"resource":{"primary":{"URL":"https:\/\/andespediatrica.cl\/index.php\/rchped\/article\/view\/4050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,18]]}},"URL":"https:\/\/doi.org\/10.32641\/andespediatr.v93i4.4050","relation":{},"ISSN":["2452-6053","2452-6053"],"issn-type":[{"value":"2452-6053","type":"electronic"},{"value":"2452-6053","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,18]]}}}