{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:58:59Z","timestamp":1778637539198,"version":"3.51.4"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>Introducci\u00f3n: El diagn\u00f3stico de deficiencia de hormona de crecimiento (DHC) es dif\u00edcil de establecer, y se puede asociar a serias complicaciones, especialmente en el per\u00edodo neonatal. La prueba de est\u00edmulo de secreci\u00f3n de hormona de crecimiento (HC) se considera de elecci\u00f3n para el diagn\u00f3stico, pero presenta complicaciones metodol\u00f3gicas y se asocia a efectos adversos. Los neonatos presentan aumento de la secreci\u00f3n de HC de forma fisiol\u00f3gica, siendo una ventana diagn\u00f3stica.Objetivo: Evaluar si la muestra de sangre en papel filtro tomada en el per\u00edodo neonatal, en contexto del tamizaje neonatal de hipotiroidismo cong\u00e9nito y fenilcetonuria, permite diferenciar pacientes con DHC, de los que no la presentan.Pacientes y M\u00e9todo: Estudio de casos y controles mediante determinaci\u00f3n de concentraci\u00f3n de HC en sangre de papel filtro extra\u00edda en per\u00edodo neonatal, comparando controles con DHC con casos con deficiencia descartada. Se realiz\u00f3 extracci\u00f3n de la muestra del papel filtro, obteniendo dos discos de 0,125 pulgada por cada uno de los pacientes desde el centro de la mancha de sangre del papel, para un ELISA de HC humana altamente sensible basado en el uso de anticuerpos policlonales dirigidos contra la HC humana recombinante de 22kDa de peso molecular.Resultados: Se obtuvo un total de 7 casos de DHC y 10 controles. La mediana de concentraci\u00f3n de HC de papel filtro en los casos es 2,0 ng\/ml (Rango intercuartil 3,6 ng\/ml) y controles 2,05 ng\/mL (RIC 2,0 ng\/ml), U de Mann-Withney 30,5 (p = 0,68). Los dos casos con deficiencia de hormonas hipofisarias m\u00faltiples (DHHM) presentan concentraciones menores a 1 ng\/ml.Conclusi\u00f3n: La muestra de papel filtro no permiti\u00f3 diferenciar a los pacientes con DHC de los casos controles, aunque los casos con DHHM presentaron concentraciones mucho menores, en comparaci\u00f3n a la deficiencia de hormona de crecimiento aislada (DHCA).<\/jats:p>","DOI":"10.32641\/rchped.v90i2.674","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:36:55Z","timestamp":1557257815000},"page":"145","source":"Crossref","is-referenced-by-count":3,"title":["Hormona de crecimiento en sangre de papel filtro para el diagn\u00f3stico de deficiencia de hormona de crecimiento"],"prefix":"10.32641","volume":"90","author":[{"given":"G.","family":"Dominguez-Men\u00e9ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cifuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lagos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rumi\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mart\u00ednez-Aguayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2019,4,10]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/674\/1141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/674\/1141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:27:40Z","timestamp":1618252060000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,4,10]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v90i2.674","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,10]]}}}