{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:56:37Z","timestamp":1774328197709,"version":"3.50.1"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>Objetivo: Determinar los principales factores de riesgo asociados a candidemia en neonatos.Pacientes y M\u00e9todo: Se realiz\u00f3 un estudio de casos y controles retrospectivo pareado, desde enero de 2014 a diciembre de 2016. Los casos fueron pacientes con aislamiento en hemocultivo y\/o l\u00edquido cefalorraqu\u00eddeo de Candida spp. luego de sus primeras 48 horas intrahospitalarias y los controles fueron neonatos escogidos del censo estad\u00edstico de la sala de neonatolog\u00eda pareados seg\u00fan su fecha de admisi\u00f3n a sala (rango de 30 d\u00edas), peso al nacer, edad gestacional y condici\u00f3n de egreso (vivo o fallecido). Por cada caso seleccionamos dos controles. Los factores de riesgo evaluados fueron la estancia intrahospitalaria mayor a 7 d\u00edas, el uso de antibi\u00f3ticos de amplio espectro, ventilaci\u00f3n mec\u00e1nica, nutrici\u00f3n parenteral mayor a 5 d\u00edas, procedimientos invasivos como colocaci\u00f3n de accesos venosos centrales y cirug\u00edas abdominales y tor\u00e1cicas, enterocolitis necrosante y crecimiento de microorganismo bacteriano en hemocultivo previo a la candidemia.Resultados: Durante el per\u00edodo de estudio hubo aislamiento de Candida spp. en 141 neonatos. Se encontr\u00f3 que el 49% fue de Candida parapsilosis con la mayor letalidad asociada. En el an\u00e1lisis multivariado se identificaron como factores de riesgo la estancia intrahospitalaria mayor a 7 d\u00edas (OR = 17,0, 95% IC = 2,36-122,4), uso de l\u00edneasumbilicales (OR = 9,04, 95% IC = 1,55-52,5), exposici\u00f3n a cirug\u00eda (OR = 12,4, 95% IC = 1,76-87,3) y el uso de meropenem (OR = 4,62, 95% IC = 1,34-15,9).Conclusi\u00f3n: La estancia intrahospitalaria prolongada mayor a 7 d\u00edas y la exposici\u00f3n a cirug\u00eda fueron los factores de riesgo m\u00e1s importantes en este estudio para el desarrollo de candidemia neonatal.<\/jats:p>","DOI":"10.32641\/rchped.v90i2.717","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:36:55Z","timestamp":1557257815000},"page":"186","source":"Crossref","is-referenced-by-count":7,"title":["Factores de riesgo y letalidad asociados a Candidemia Neonatal en una unidad de neonatolog\u00eda"],"prefix":"10.32641","volume":"90","author":[{"given":"Elizabeth","family":"Capar\u00f3 Ingram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"V\u00e1squez Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Norero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"S\u00e1ez-Llorens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"DeAntonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Rodr\u00edguez Barr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2019,4,10]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/717\/1146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/717\/1146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:27:41Z","timestamp":1618252061000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,4,10]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v90i2.717","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4,10]]}}}