{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:07:47Z","timestamp":1778170067244,"version":"3.51.4"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>El S\u00edndrome de Guillain-Barr\u00e9 (SGB) es raramente diagnosticado en lactantes menores de 1 a\u00f1o. Su asociaci\u00f3n con el S\u00edndrome de Wiskott Aldrich (SWA), es a\u00fan menos frecuente, y ha sido previamente reportada s\u00f3lo en dos pacientes a nuestro conocimiento. La hidrocefalia, es una complicaci\u00f3n conocida, pero infrecuente del SGB.Objetivo: presentar el caso cl\u00ednico de un lactante en el que se asocian las patolog\u00edas de SGB, SWA e hidrocefalia.Caso Cl\u00ednico: varon de 9 meses, portador de SWA hospitalizado en unidad de cuidados intensivos por hipoton\u00eda aguda y compromiso del estado general. Evolucion\u00f3 con par\u00e1lisis fl\u00e1ccida, falla ventilatoria y arreflexia generalizada. Una punci\u00f3n lumbar mostr\u00f3 disociaci\u00f3n albuminocitol\u00f3gica, y el estudio electrofisiol\u00f3gico mostr\u00f3 signos de polineuropat\u00eda desmielinizante severa. Se trat\u00f3 con inmunoglobulina, evolucionando en forma satisfactoria. Por bradicardia intermitente, se realiz\u00f3 tomograf\u00eda axial computada cerebral (TAC), que mostr\u00f3 signos de una hidrocefalia aguda, manejada mediante v\u00e1lvula derivativa ventr\u00edculo peritoneal con favorable respuesta. En el largo plazo, se someti\u00f3 a trasplante de m\u00e9dula \u00f3sea y debi\u00f3 ser reintervenido por complicaciones valvulares, sin embargo, su desarrollo psicomotor es normal sin secuelas neurol\u00f3gicas evidentes hasta los 3 a\u00f1os.Conclusi\u00f3n: Presentamos el tercer caso de SGB en un paciente portador de SWA, destacando ser el primero de ellos en un lactante menor de 1 a\u00f1o. Adicionalmente, este ni\u00f1o present\u00f3 una hidrocefalia aguda como complicaci\u00f3n del SGB. Consideramos relevante tener presente estas comorbilidades, debido a que su pronto diagn\u00f3stico y manejo oportuno, permiten una mejor recuperaci\u00f3n neurol\u00f3gica y evitan complicaciones potencialmente letales.\u00a0<\/jats:p>","DOI":"10.32641\/rchped.v91i1.1208","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T02:13:10Z","timestamp":1580955190000},"page":"105","source":"Crossref","is-referenced-by-count":2,"title":["S\u00edndrome de Guillain Barr\u00e9 e hidrocefalia en un lactante con S\u00edndrome de Wiskott Aldrich"],"prefix":"10.32641","volume":"91","author":[{"given":"Daniela","family":"Avila-Smirnow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"C\u00f3rdova-Aguilera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi\u00e1n","family":"Cantillano-Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Arriaza-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Wegner-Araya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,2,6]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1208\/1565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1208\/1565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:06Z","timestamp":1618252086000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,2,6]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i1.1208","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,6]]}}}