{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T05:45:02Z","timestamp":1743572702419},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>Un 20% de los ni\u00f1os con s\u00edndrome febril se presenta como s\u00edndrome febril sin foco (SFSF). Las estrategias de manejo en este grupo presentan alta sensibilidad, pero baja especificidad.Objetivos: Caracterizar las infecciones bacterianas serias (IBS) en menores de 3 meses hospitalizados por SFSF, y evaluar utilidad de par\u00e1metros cl\u00ednicos y de laboratorio en la identificaci\u00f3n de pacientes con alto riesgo de IBS.Pacientes y M\u00e9todo: Estudio prospectivo en pacientes &lt; 3 meses hospitalizados entre\u00a0enero 2014 y noviembre 2015 por SFSF en dos hospitales pedi\u00e1tricos de la Regi\u00f3n Metropolitana. Criterios de inclusi\u00f3n: edad 4 d\u00edas - 3 meses, fiebre &gt; 38\u00baC de &lt; 72 h de evoluci\u00f3n sin causa demostrable. Criterios de exclusi\u00f3n: uso de antimicrobianos hasta 7 d\u00edas previo a su ingreso, prematuros &lt; 34 semanas, peso de nacimiento &lt; 2 kg e inmunocomprometidos. Se registraron datos demogr\u00e1ficos, cl\u00ednicos, y ex\u00e1menes de laboratorio, hemograma y PCR, diagn\u00f3stico de egreso, IBS descartada, IBS probable o confirmada.Resultados: 32% de los pacientes egres\u00f3 con diagn\u00f3stico de IBS, 28% con diagn\u00f3stico de infecci\u00f3n viral o probablemente viral, 34% con diagn\u00f3stico de SFSF no especificado y 6% SFSF por otras causas. No se encontraron diferencias significativas en PCR, leucocitosis, aspecto t\u00f3xico ni horas de fiebre al ingreso al comparar los grupos con y sin IBS (p &gt; 0,05). La combinaci\u00f3n de par\u00e1metros cl\u00ednicos y de laboratorio mostro sensibilidad de 27%, especificidad de 90%, VPP 60% y VPN 71%.Conclusi\u00f3n: No fue posible establecer que par\u00e1metros cl\u00ednicos y de laboratorio permitan identificar menores de 3 meses con alto riesgo de IBS, manteniendo su utilidad como indicadores de bajo riesgo. Es necesario contar con otros elementos cl\u00ednicos y de laboratorio que permitan discriminar IBS de infecciones virales.<\/jats:p>","DOI":"10.32641\/rchped.v91i2.1261","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T16:40:47Z","timestamp":1588005647000},"page":"199","source":"Crossref","is-referenced-by-count":1,"title":["Utilidad de los par\u00e1metros cl\u00ednicos y de laboratorio b\u00e1sicos para predecir infecci\u00f3n bacteriana seria en menores de 3 meses que se hospitalizan por s\u00edndrome febril sin foco"],"prefix":"10.32641","volume":"91","author":[{"given":"Macarena","family":"Moya I.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardita","family":"Couble P.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Pi\u00f1era M.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma","family":"Suau C.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Fritis L.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Roa R.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham IJ","family":"Gajardo Cortez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,4,22]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1261\/1920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1261\/1920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:20Z","timestamp":1618252100000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,22]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i2.1261","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,22]]}}}