{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:56:33Z","timestamp":1764402993602},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>Introducci\u00f3n: La inmovilizaci\u00f3n prolongada asociada a diversas enfermedades neurol\u00f3gicas, causa osteoporosis secundaria con fracturas patol\u00f3gicas y dolor \u00f3seo persistenteObjetivos: Establecer la asociaci\u00f3n entre densidad mineral \u00f3sea (DMO), marcadores de neoformaci\u00f3n y reabsorci\u00f3n \u00f3sea y grado de capacidad funcional en pacientes menores de 18 a\u00f1os con movilidad reducida.Pacientes y M\u00e9todo: Estudio transversal, realizado entre 1\/1\/2016 y 31\/12\/2017 en pacientes de 6 a 18 a\u00f1os diagnosticados de distintas enfermedades neurol\u00f3gicas en Ciudad Real (Espa\u00f1a). Se analizaron las variables biodemogr\u00e1ficas, capacidad funcional seg\u00fan la Functional Mobility Scale (FMS), que valora la movilidad en 5, 50 y 500 metros, DMO, 25-hidroxi-vitamina D, fosfatasa alcalina, osteocalcina en sangre y telop\u00e9ptido amino terminal de cadena cruzada de col\u00e1geno tipo I en orina (NTX-I). Se expresan DMO, fosfatasa alcalina, osteocalcina y NTX-I en Z score seg\u00fan valores de referencia para\u00a0edad y sexo. Se utilizaron estad\u00edsticas descriptivas y correlaciones de Pearson y Spearman.Resultados: 36 pacientes (52,7% ni\u00f1as), edad media de 8,6 \u00b1 4,7 a\u00f1os. Valor medio de FMS: 5,3 sobre 18. DMO media: -1,99 \u00b1 1,7 desviaciones est\u00e1ndar (DE), fosfatasa alcalina media: -2,64 \u00b1 1,08, osteocalcina media: -2,15 \u00b1 1,39, y NTX-I medio: +3 \u00b1 1,72. Hubo asociaci\u00f3n significativa entre DMO y FMS para 5 metros (r = 0,395; p = 0,017) y para la puntuaci\u00f3n total (r = 0,365; p = 0,029). No se encontraron diferencias significativas seg\u00fan estadios de desarrollo puberal.Conclusiones: En la poblaci\u00f3n estudiada se observa disminuci\u00f3n en la DMO y en marcadores de neoformaci\u00f3n \u00f3sea y elevaci\u00f3n de marcadores de reabsorci\u00f3n \u00f3sea sin asociaci\u00f3n con el desarrollo puberal. Los pacientes con menor grado de movilidad presentan una DMO inferior.<\/jats:p>","DOI":"10.32641\/rchped.v91i2.1269","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T16:40:47Z","timestamp":1588005647000},"page":"209","source":"Crossref","is-referenced-by-count":1,"title":["Capacidad funcional, densidad mineral \u00f3sea y marcadores de neoformaci\u00f3n - reabsorci\u00f3n \u00f3sea en pacientes menores de 18 a\u00f1os con movilidad reducida"],"prefix":"10.32641","volume":"91","author":[{"given":"Enrique","family":"Palomo Atance","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Medica Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. Luisa","family":"Le\u00f3n S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Mu\u00f1oz-Rodr\u00edguezc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodr\u00edguez Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Montoli\u00fa Peco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,4,22]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1269\/1596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1269\/1596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:21Z","timestamp":1618252101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,22]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i2.1269","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,22]]}}}