{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:04:34Z","timestamp":1747217074901,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>En pacientes con S\u00edndrome de Hipoplasia de Ventr\u00edculo Izquierdo (SHVI) la primera etapa hacia una fisiolog\u00eda univentricular de Fontan es la operaci\u00f3n de Norwood, cuya mortalidad es 10-30%. En estos pacientes la extubaci\u00f3n fallida se presenta en un 18% y se ha asociado a aumento de la mortalidad.Objetivo: Describir la frecuencia de extubaci\u00f3n fallida y sus factores de riesgo en pacientes con SHVI operados (Norwood).Pacientes y M\u00e9todo:\u00a0Estudio de casos y controles que incluy\u00f3 a todos los pacientes con SHVI manejados con cirug\u00eda de Norwood en el Hospital Cl\u00ednico de la Pontificia Universidad Cat\u00f3lica (enero-2000 a febrero-2018). Se define como casos a pacientes con falla en la extubaci\u00f3n y como controles a los pacientes sin esta complicaci\u00f3n. Se registraron variables demogr\u00e1ficas, quir\u00fargicas, y post-quir\u00fargicas, y se realiz\u00f3 an\u00e1lisis univariado y multivariado (regresi\u00f3n log\u00edstica) para determinar los factores de riesgo asociados a la falla en la extubaci\u00f3n.Resultados:\u00a0De un total de 107 pacientes, 26 pacientes tuvieron extubaci\u00f3n fallida (24,3%). En el an\u00e1lisis univariado los factores asociados a extubaci\u00f3n fallida fueron: mayor tiempo de ventilaci\u00f3n mec\u00e1nica postquir\u00fargico, desarrollar atelectasias, derrame pleural, quilot\u00f3rax, tener otras comorbilidades respiratorias (apnea y traque\u00edtis), y mayor tiempo de uso de morfina y midazolam. En el an\u00e1lisis multivariado, la presencia de quilot\u00f3rax, otras comorbilidades respiratorias, y mayor tiempo de uso de midazolam fueron variables asociadas a extubaci\u00f3n fallida (p&lt;0,03). La extubaci\u00f3n fallida no se asoci\u00f3 a mayor mortalidad.Conclusiones: La presencia de quilot\u00f3rax, complicaciones respiratorias y uso de midazolam prolongado deben considerarse para definir el momento de la extubaci\u00f3n, con el objetivo de evitar su fracaso.<\/jats:p>","DOI":"10.32641\/rchped.v91i3.1167","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T14:44:42Z","timestamp":1592577882000},"page":"391","source":"Crossref","is-referenced-by-count":4,"title":["Extubaci\u00f3n fallida postoperaci\u00f3n de Norwood en pacientes con s\u00edndrome de hipoplasia de ventr\u00edculo izquierdo"],"prefix":"10.32641","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-1465","authenticated-orcid":false,"given":"Adolfo","family":"Herrera J.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Springmuller P.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Del Pozo B.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Cerda L.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Adasme J.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Castillo M.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,6,19]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1167\/2409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1167\/2409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:25Z","timestamp":1618252105000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,6,19]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i3.1167","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"type":"electronic","value":"0370-4106"},{"type":"print","value":"0370-4106"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}