{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T15:40:08Z","timestamp":1722699608864},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>La trombosis senovenosa cerebral neonatal (TSVC), es una patolog\u00eda rara y generalmente grave, de la cual se conoce poco sobre los mecanismos fisiopatol\u00f3gicos responsables y, aunque controvertido, se ha sugerido que la trombofilia gen\u00e9tica, puede desempe\u00f1ar un rol en la patog\u00e9nesis. Debido a los temores de un sangrado intracraneal el tratamiento anticoagulante con heparina de bajo peso molecular es controvertido.Objetivo: presentar un reci\u00e9n nacido con una trombosis senovenosa cerebral neonatal, discutir los factores de riesgo trombof\u00edlico, y el manejo con heparina de bajo peso molecular de la trombosis venosa cerebral.Caso Cl\u00ednico: Reci\u00e9n nacido de t\u00e9rmino que debut\u00f3 a los 8 d\u00edas de vida con convulsiones cl\u00f3nicas, rechazo al pecho m\u00e1s hipoactividad motora. La neuroimagen con RM mostr\u00f3 una TSVC involucrando m\u00faltiples senos venosos, un infarto hemorr\u00e1gico tal\u00e1mico derecho y congesti\u00f3n venosa de la sustancia blanca frontal. El estudio de trombofilia puso de relieve una\u00a0mutaci\u00f3n homocigota del gen MTHFR C677T. El tratamiento con heparina de bajo peso molecular se asoci\u00f3 a repermeabilizaci\u00f3n del seno sagital superior a los 23 d\u00edas de iniciada la terapia.Conclusiones: La presentaci\u00f3n cl\u00ednica de la TSVC en el neonato es inespec\u00edfica, probablemente en relaci\u00f3n con la extensi\u00f3n y gravedad de la lesi\u00f3n y el desarrollo de complicaciones asociadas, como infartos hemorr\u00e1gicos venosos intraparenquimatosos o hemorragia intraventricular. Estas complicaciones son detectables mediante Ecografia o Resonancia Magn\u00e9tica, y deben hacer sospechar una TSVC. En esta experiencia el tratamiento anticoagulante mostr\u00f3 ser seguro y prevenir la extensi\u00f3n de la trombosis.<\/jats:p>","DOI":"10.32641\/rchped.v91i3.1270","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T14:44:42Z","timestamp":1592577882000},"page":"417","source":"Crossref","is-referenced-by-count":1,"title":["Trombosis senovenosa cerebral en un reci\u00e9n nacido con mutaci\u00f3n MTHFR C677T tratado con enoxaparina"],"prefix":"10.32641","volume":"91","author":[{"given":"Juan","family":"Fasce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Calbacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Oyarz\u00fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Reinbach Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"Daza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Garc\u00eda-Alix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,6,19]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1270\/1924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1270\/1924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:27Z","timestamp":1618252107000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,6,19]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i3.1270","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}